This application requests continued support for the NIEHS Center in Environmental Toxicology (UTMB-CET) at the University of Texas Medical Branch at Galveston. The mission of this Center is to integrate, coordinate and foster interactions and collaborations among a multidisciplinary group of established investigators pursuing research pertinent to the effects of environmental factors on human health. The investigators'proximity to sources of many significant environmental problems, such as ozone pollution, emissions of fine particulates, hazardous chemical releases, and hazardous waste sites makes UTMB a compelling site for an environmental health sciences Center. During the fifteen years of its existence, this Center has emerged as a national leader in elucidating cellular response mechanisms to environmental challenge, and in working with the community to enhance awareness of environmental health issues and elaborate prevention and intervention strategies. The overarching theme of the UTMB-CET is the role of oxidative stress in mediating the health effects of exposure to environmental factors. The Center supports multidisciplinary research, organized as Collaborative Research Teams (CRTs) integrating diverse approaches, to examine basic and translational research problems in environmental health. The CRT represents a transformative organizational structure that promotes and rewards collaborative team-based research. The UTMB-CET promotes mentored career development of young investigators, taking advantage of the CRT setting to enhance the training experience. Translational research activities are supported by five facilities within the Integrative Health Science Facility Core, providing the linkage between Center investigators, clinical resources, bioinformatic and biostatistical support services, and community resources. Center investigators are also aided by three established Facility Cores (Molecular Genetics, Biomolecular Resource Facility, and Synthetic Organic Chemistry) that provide advanced technologies, unique reagents, and specialized expertise for both basic and translational studies in a cost-effective manner. Scientific findings from the Center are communicated to the public through a vibrant Community Outreach and Engagement Core, with advice from a Stakeholder Advisory Board. The various activities of the UTMB-CET are coordinated by an Administrative Core, which receives input from an Internal Advisory Board, External Advisory Board, and the Executive Committee, and oversees a variety of programs including a Pilot Project Program, a seminars series, the Director's Fund, and a Discount Management Program. The UTMB-CET supports an outstanding portfolio of research projects in the field of environmental health sciences, with clear translational impact or potentia.

Public Health Relevance

The NIEHS P30 Core Center at the University of Texas Medical Branch (UTMB) provides investigators at UTMB engaged in environmental issues relevant to human health with an infrastructure designed to promote research examining these concerns. Specifically, the Center supports teams of collaborators with essential resources, including access to equipment, skilled personnel and seed monies needed to perform the research. In addition, the Center maintains a structured mentoring program geared towards career development for investigators at various stages of their careers, and active dialog with the lay community impacted by the many environmental health concerns being scientifically addressed by Center investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES006676-17
Application #
8490587
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
1997-04-01
Project End
2017-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
17
Fiscal Year
2013
Total Cost
$1,237,900
Indirect Cost
$592,154
Name
University of Texas Medical Br Galveston
Department
Pharmacology
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Sun, Yue; Ban, Bhupal; Bradbury, Andrew et al. (2016) Combining Yeast Display and Competitive FACS to Select Rare Hapten-Specific Clones from Recombinant Antibody Libraries. Anal Chem 88:9181-9
Nutter, Curtis A; Jaworski, Elizabeth A; Verma, Sunil K et al. (2016) Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. Cell Rep 15:2200-13
Pazdrak, Konrad; Straub, Christof; Maroto, Rosario et al. (2016) Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling. J Immunol 197:3782-3791
Bacsi, Attila; Pan, Lang; Ba, Xueqing et al. (2016) Pathophysiology of bronchoconstriction: role of oxidatively damaged DNA repair. Curr Opin Allergy Clin Immunol 16:59-67
Chakraborty, Anirban; Tapryal, Nisha; Venkova, Tatiana et al. (2016) Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Nat Commun 7:13049
Zhao, Yingxin; Valbuena, Gustavo; Walker, David H et al. (2016) Endothelial Cell Proteomic Response to Rickettsia conorii Infection Reveals Activation of the Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT)-Inferferon Stimulated Gene (ISG)15 Pathway and Reprogramming Plasma Membrane Integrin/ Mol Cell Proteomics 15:289-304
Choudhary, Sanjeev; Boldogh, Istvan; Brasier, Allan R (2016) Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity. J Innate Immun 8:143-55
Kaphalia, Lata; Kalita, Mridul; Kaphalia, Bhupendra S et al. (2016) Effects of acute ethanol exposure on cytokine production by primary airway smooth muscle cells. Toxicol Appl Pharmacol 292:85-93
German, Peter; Saenz, David; Szaniszlo, Peter et al. (2016) 8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging. Mech Ageing Dev :
Ijaz, Talha; Wakamiya, Maki; Sun, Hong et al. (2016) Generation and characterization of a novel transgenic mouse harboring conditional nuclear factor-kappa B/RelA knockout alleles. BMC Dev Biol 16:32

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