I. Overview The mission of the Career Development Core (CDC) is to provide career training for the new generation of environmental health (EH) scientists, to nurture young faculty and foster their transition to independence, and to attract established scientists and integrate their disciplines into the area of EH. The philosophy of the CDC is that career training is a continuum starting with doctoral training (Ph.D./M.D.) and proceeding through postdoctoral training and subsequent development as junior faculty. Thus graduate and postdoctoral training are equally important for the trajectory of EH science (EHS) professionals. Special emphasis is placed on the career training of clinician-scientists who might not otherwise identify their interests in EH. Women and underrepresented minorities are highly sought as participants. Senior investigators will also be attracted to the field by the appeal of the multidisciplinary paradigm championed by the CDC. The CDC fosters translational and clinical careers in EH sciences by involving an interactive group of scientists from multiple UA Colleges, Departments, and Centers of Excellence, all interested in exploring the role of the environment in disease pathogenesis. Exposure of junior investigators to a multidisciplinary culture, close mentoring by basic and clinical scientists, and access to state-of the-art, empowering technologies will ensure the emergence of a new generation of skilled investigators and provide them with an edge that will foster their career progression to seniority. An outstanding track record of productive collaborations renders the CDC faculty uniquely qualified to spearhead the innovative mentoring endeavor proposed herein. The goals of the CDC are (a) to continue to develop our NIEHS-supported graduate training programs in Toxicology and EHS;(b) to submit Training Grants in EHS to benefit both basic and clinician-scientist trainees;(c) to recruit junior faculty as SWEHSC investigators;(d) to further develop mentoring committees and formalized career development plans for junior investigators;(e) to identify candidates that could apply for pilot project funding from the SWEHSC as well as extramural funding in EHS research;and (f) to attract into EHS established investigators from other fields. Each of these components has metrics of success. The CDC has been successful in accomplishing these goals as outlined below.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES006694-18
Application #
8650847
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
18
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Yu, Ai-Ming; Ingelman-Sundberg, Magnus; Cherrington, Nathan J et al. (2017) Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO). Acta Pharm Sin B 7:241-248
Vrba, Lukas; Futscher, Bernard Walter (2017) Epigenetic Silencing of MORT Is an Early Event in Cancer and Is Associated with Luminal, Receptor Positive Breast Tumor Subtypes. J Breast Cancer 20:198-202
Bashyal, Bharat P; Wijeratne, E M Kithsiri; Tillotson, Joseph et al. (2017) Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus. J Nat Prod 80:427-433
Padi, Sathish K R; Luevano, Libia A; An, Ningfei et al. (2017) Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. Oncotarget 8:30199-30216
Rojo de la Vega, Montserrat; Krajisnik, Andrea; Zhang, Donna D et al. (2017) Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin. Nutrients 9:
Lothrop, Nathan; Hussaini, Khaleel; Billheimer, Dean et al. (2017) Community-level characteristics and environmental factors of child respiratory illnesses in Southern Arizona. BMC Public Health 17:516
Han, JianHua; Dzierlenga, Anika L; Lu, Zhengqiang et al. (2017) Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model. Obesity (Silver Spring) 25:1069-1076
Justiniano, Rebecca; Williams, Joshua D; Perer, Jessica et al. (2017) The B6 -vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis. Photochem Photobiol 93:990-998
Cho, Soohee; Yoon, Jeong-Yeol (2017) Organ-on-a-chip for assessing environmental toxicants. Curr Opin Biotechnol 45:34-42
Clarke, John D; Novak, Petr; Lake, April D et al. (2017) Impaired N-linked glycosylation of uptake and efflux transporters in human non-alcoholic fatty liver disease. Liver Int 37:1074-1081

Showing the most recent 10 out of 929 publications