This application is to continue our Southern California Environmental Health Services Center whose main purposes are 1) to study the effects of environmental exposures on humans; 2) to determine host factors (genetic and other) influencing response to these exposures; and 3) to inform the public. To accomplish these goals we bring together an interdisciplinary team of investigators from 2 major Souther California universities: USC and UCLA. The research of our Center features interdisciplinary cornerstones: detained exposure assessment, including toxicokinetics and biomarkers; cutting edge study design, including the most powerful statistical and epidemiologic approaches; and the basic sciences, including physiology, molecular biology, genetics, chemistry and engineering. The foci of the Center cover a wide range of problems and address environmental exposures of public health importance including indoor and outdoor air pollution, pesticides, alflatoxins, radiation, passive smoking, bioaerosols and nitrites. The 5 Research Cores consist of: Respiratory Effects; Exposure Assessment; Childhood Cancer, Adult Cancer Study Design and Statistical Methodology. The 3 Facility Cores consist of: the Molecular Biology, Sample Processing and Storage Core; the Analytic Chemistry, Exposure Assessment and Aerosol Sciences Core; and the Biostatistics Core. The Center also features a separate core for Community Outreach and Education (COEP). The Center is structured to promote interdisciplinary research and linkage between the research and the COEP. Processes creating these interactions include the seminar series, pilot projects, research focus groups, workshops and retreats. The first 4 years of support for this Center have resulted in recruitment of new investigators, more investigators working on environmental health problems, doubling of funding support, more interaction between researchers from different disciplines and a greater production of research findings relevant to answering critical public health questions. The Center also developed research initiatives for the next 5 years that focus the interdisciplinary team of investigators on important environmental health problems involving genetic-environmental interactions as asthma and cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007048-08
Application #
6635464
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Collman, Gwen W
Project Start
1996-04-01
Project End
2006-03-03
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
8
Fiscal Year
2003
Total Cost
$1,451,970
Indirect Cost
Name
University of Southern California
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Liu, Gang; Mukherjee, Bhramar; Lee, Seunggeun et al. (2018) Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence. Am J Epidemiol 187:366-377
Wheelock, Kylie; Zhang, Junfeng Jim; McConnell, Rob et al. (2018) A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons. Environ Sci Process Impacts :
Younan, Diana; Tuvblad, Catherine; Franklin, Meredith et al. (2018) Longitudinal Analysis of Particulate Air Pollutants and Adolescent Delinquent Behavior in Southern California. J Abnorm Child Psychol 46:1283-1293
Barrington-Trimis, Jessica L; Leventhal, Adam M; Alonzo, Todd A et al. (2018) Performance of cigarette susceptibility index among e-cigarette and hookah users. Drug Alcohol Depend 183:43-50
Ogasawara, Noriko; Poposki, Julie A; Klingler, Aiko I et al. (2018) IL-10, TGF-?, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol 141:1147-1151.e8
Urman, Robert; McConnell, Rob; Unger, Jennifer B et al. (2018) Electronic Cigarette and Cigarette Social Environments and Ever Use of Each Product: A Prospective Study of Young Adults in Southern California. Nicotine Tob Res :
Farzan, Shohreh F; Howe, Caitlin G; Chen, Yu et al. (2018) Prenatal lead exposure and elevated blood pressure in children. Environ Int 121:1289-1296
Cho, Junhan; Goldenson, Nicholas I; Stone, Matthew D et al. (2018) Characterizing Polytobacco Use Trajectories and Their Associations With Substance Use and Mental Health Across Mid-Adolescence. Nicotine Tob Res 20:S31-S38
Moss, Lilit C; Gauderman, William J; Lewinger, Juan Pablo et al. (2018) Using Bayes model averaging to leverage both gene main effects and G?×? E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol :
Chen, Wansu; Qian, Lei; Shi, Jiaxiao et al. (2018) Comparing performance between log-binomial and robust Poisson regression models for estimating risk ratios under model misspecification. BMC Med Res Methodol 18:63

Showing the most recent 10 out of 653 publications