The Southern California Environmental Health Sciences Center's theme is Environmental Exposures, Host Factors and Human Disease. The Center has a multidisciplinary team of investigators from Southern California and features several interdisciplinary cornerstones: detailed exposure assessment;cutting-edge study design;and the basic sciences, including physiology, molecular biology, genetics, physics, chemistry, and engineering. The Center emphasizes environmental exposures of public health importance including air pollution, pesticides, ultraviolet and ionizing radiation, and secondhand smoke. The Center is structured to foster cutting-edge environmental health sciences (EHS) research, build research capacity, recruit and develop investigators, and promote interdisciplinary linkage between research and outreach. It is led by a team of highly accomplished investigators who have a record of collaboration and scientific productivity. Four Research Cores (Cancer, Cardio-respiratory Effects, Exposure Assessment, and Study Design) and two Facility Cores (Biostatistics and Integrative Health Sciences) are the primary structural elements. The Center also features a dynamic Community Outreach and Education Core and a robust Career Development Program. During the 14 years of support, the Center has catalyzed research that has filled critical gaps in environmental health science as well as raised new questions that need to be answered. The Center has been instrumental in recruiting new and accomplished investigators to environmental health science. It has nurtured new research ideas, stimulated greater interactions in existing and new multidisciplinary teams, and supported the development of new technologies and state-of-the-art facilities. The Center's research initiatives for the next five years are new approaches for Chemical and Biological-Based Exposure Assessment for Pollutants;Environmental Epigenomics;Environmental Contributions to Obesity;Pathway Approaches to Linking Environment, Genetics and Health;Air Pollution, Neurodevelopment and Neurological Diseases;Global Environmental Health and Climate Change;and Sunlight in Health and Disease. The Center is poised to advance research in these areas by building on its successful approaches in facilitating cutting-edge environmental health science research.

Public Health Relevance

The Center's main purpose is to fulfill the promise of prevention and reduce the burden of environmentally related diseases by identifying emerging problems, better characterizing environmental hazards, understanding the basis for personal vulnerability, and promoting the translation of research into preventive action.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007048-18
Application #
8451532
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
1997-04-01
Project End
2016-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
18
Fiscal Year
2013
Total Cost
$1,741,510
Indirect Cost
$696,237
Name
University of Southern California
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Liu, Gang; Mukherjee, Bhramar; Lee, Seunggeun et al. (2018) Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence. Am J Epidemiol 187:366-377
Wheelock, Kylie; Zhang, Junfeng Jim; McConnell, Rob et al. (2018) A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons. Environ Sci Process Impacts :
Barrington-Trimis, Jessica L; Leventhal, Adam M; Alonzo, Todd A et al. (2018) Performance of cigarette susceptibility index among e-cigarette and hookah users. Drug Alcohol Depend 183:43-50
Younan, Diana; Tuvblad, Catherine; Franklin, Meredith et al. (2018) Longitudinal Analysis of Particulate Air Pollutants and Adolescent Delinquent Behavior in Southern California. J Abnorm Child Psychol 46:1283-1293
Urman, Robert; McConnell, Rob; Unger, Jennifer B et al. (2018) Electronic Cigarette and Cigarette Social Environments and Ever Use of Each Product: A Prospective Study of Young Adults in Southern California. Nicotine Tob Res :
Ogasawara, Noriko; Poposki, Julie A; Klingler, Aiko I et al. (2018) IL-10, TGF-?, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol 141:1147-1151.e8
Cho, Junhan; Goldenson, Nicholas I; Stone, Matthew D et al. (2018) Characterizing Polytobacco Use Trajectories and Their Associations With Substance Use and Mental Health Across Mid-Adolescence. Nicotine Tob Res 20:S31-S38
Farzan, Shohreh F; Howe, Caitlin G; Chen, Yu et al. (2018) Prenatal lead exposure and elevated blood pressure in children. Environ Int 121:1289-1296
Chen, Wansu; Qian, Lei; Shi, Jiaxiao et al. (2018) Comparing performance between log-binomial and robust Poisson regression models for estimating risk ratios under model misspecification. BMC Med Res Methodol 18:63
Moss, Lilit C; Gauderman, William J; Lewinger, Juan Pablo et al. (2018) Using Bayes model averaging to leverage both gene main effects and G?×? E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol :

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