The Southern California Environmental Health Sciences Center's theme is Environmental Exposures, Host Factors and Human Disease. The Center has a multidisciplinary team of investigators from Southern California and features several interdisciplinary cornerstones: detailed exposure assessment;cutting-edge study design;and the basic sciences, including physiology, molecular biology, genetics, physics, chemistry, and engineering. The Center emphasizes environmental exposures of public health importance including air pollution, pesticides, ultraviolet and ionizing radiation, and secondhand smoke. The Center is structured to foster cutting-edge environmental health sciences (EHS) research, build research capacity, recruit and develop investigators, and promote interdisciplinary linkage between research and outreach. It is led by a team of highly accomplished investigators who have a record of collaboration and scientific productivity. Four Research Cores (Cancer, Cardio-respiratory Effects, Exposure Assessment, and Study Design) and two Facility Cores (Biostatistics and Integrative Health Sciences) are the primary structural elements. The Center also features a dynamic Community Outreach and Education Core and a robust Career Development Program. During the 14 years of support, the Center has catalyzed research that has filled critical gaps in environmental health science as well as raised new questions that need to be answered. The Center has been instrumental in recruiting new and accomplished investigators to environmental health science. It has nurtured new research ideas, stimulated greater interactions in existing and new multidisciplinary teams, and supported the development of new technologies and state-of-the-art facilities. The Center's research initiatives for the next five years are new approaches for Chemical and Biological-Based Exposure Assessment for Pollutants;Environmental Epigenomics;Environmental Contributions to Obesity;Pathway Approaches to Linking Environment, Genetics and Health;Air Pollution, Neurodevelopment and Neurological Diseases;Global Environmental Health and Climate Change;and Sunlight in Health and Disease. The Center is poised to advance research in these areas by building on its successful approaches in facilitating cutting-edge environmental health science research.

Public Health Relevance

The Center's main purpose is to fulfill the promise of prevention and reduce the burden of environmentally related diseases by identifying emerging problems, better characterizing environmental hazards, understanding the basis for personal vulnerability, and promoting the translation of research into preventive action.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
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University of Southern California
Public Health & Prev Medicine
Schools of Medicine
Los Angeles
United States
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Moss, Lilit C; Gauderman, William J; Lewinger, Juan Pablo et al. (2018) Using Bayes model averaging to leverage both gene main effects and G?×? E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol :
Chen, Wansu; Qian, Lei; Shi, Jiaxiao et al. (2018) Comparing performance between log-binomial and robust Poisson regression models for estimating risk ratios under model misspecification. BMC Med Res Methodol 18:63
Pomatto, Laura C D; Cline, Mayme; Woodward, Nicholas et al. (2018) Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radic Biol Med 121:86-97
Lovett, Christopher; Cacciottolo, Mafalda; Shirmohammadi, Farimah et al. (2018) Diurnal variation in the proinflammatory activity of urban fine particulate matter (PM 2.5) by in vitro assays. F1000Res 7:596
Reiner, Anne S; Sisti, Julia; John, Esther M et al. (2018) Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study. J Clin Oncol 36:1513-1520
Alderete, Tanya L; Chen, Zhanghua; Toledo-Corral, Claudia M et al. (2018) Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes. Curr Epidemiol Rep 5:79-91
Laville, Vincent; Bentley, Amy R; Privé, Florian et al. (2018) VarExp: estimating variance explained by genome-wide GxE summary statistics. Bioinformatics 34:3412-3414
Kalkbrenner, Amy E; Windham, Gayle C; Zheng, Cheng et al. (2018) Air Toxics in Relation to Autism Diagnosis, Phenotype, and Severity in a U.S. Family-Based Study. Environ Health Perspect 126:037004
Stram, Douglas A; Jiang, Xuejuan; Varma, Rohit et al. (2018) Factors Associated with Prevalent Diabetic Retinopathy in Chinese Americans: The Chinese American Eye Study. Ophthalmol Retina 2:96-105
Dong, Jing; Levine, David M; Buas, Matthew F et al. (2018) Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus. Clin Gastroenterol Hepatol 16:1598-1606.e4

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