The Southern California Environmental Health Sciences Center's theme is Environmental Exposures, Host Factors and Human Disease. The Center has a multidisciplinary team of investigators from Southern California and features several interdisciplinary cornerstones: detailed exposure assessment;cutting-edge study design;and the basic sciences, including physiology, molecular biology, genetics, physics, chemistry, and engineering. The Center emphasizes environmental exposures of public health importance including air pollution, pesticides, ultraviolet and ionizing radiation, and secondhand smoke. The Center is structured to foster cutting-edge environmental health sciences (EHS) research, build research capacity, recruit and develop investigators, and promote interdisciplinary linkage between research and outreach. It is led by a team of highly accomplished investigators who have a record of collaboration and scientific productivity. Four Research Cores (Cancer, Cardio-respiratory Effects, Exposure Assessment, and Study Design) and two Facility Cores (Biostatistics and Integrative Health Sciences) are the primary structural elements. The Center also features a dynamic Community Outreach and Education Core and a robust Career Development Program. During the 14 years of support, the Center has catalyzed research that has filled critical gaps in environmental health science as well as raised new questions that need to be answered. The Center has been instrumental in recruiting new and accomplished investigators to environmental health science. It has nurtured new research ideas, stimulated greater interactions in existing and new multidisciplinary teams, and supported the development of new technologies and state-of-the-art facilities. The Center's research initiatives for the next five years are new approaches for Chemical and Biological-Based Exposure Assessment for Pollutants;Environmental Epigenomics;Environmental Contributions to Obesity;Pathway Approaches to Linking Environment, Genetics and Health;Air Pollution, Neurodevelopment and Neurological Diseases;Global Environmental Health and Climate Change;and Sunlight in Health and Disease. The Center is poised to advance research in these areas by building on its successful approaches in facilitating cutting-edge environmental health science research.

Public Health Relevance

The Center's main purpose is to fulfill the promise of prevention and reduce the burden of environmentally related diseases by identifying emerging problems, better characterizing environmental hazards, understanding the basis for personal vulnerability, and promoting the translation of research into preventive action.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007048-19
Application #
8650857
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
1997-04-01
Project End
2016-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
19
Fiscal Year
2014
Total Cost
$1,777,053
Indirect Cost
$644,064
Name
University of Southern California
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Woodward, Nicholas C; Pakbin, Payam; Saffari, Arian et al. (2017) Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons. Neurobiol Aging 53:48-58
Wang, Pan; Tuvblad, Catherine; Younan, Diana et al. (2017) Socioeconomic disparities and sexual dimorphism in neurotoxic effects of ambient fine particles on youth IQ: A longitudinal analysis. PLoS One 12:e0188731
Patel, Chirag J; Kerr, Jacqueline; Thomas, Duncan C et al. (2017) Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. Cancer Epidemiol Biomarkers Prev 26:1370-1380
Farzan, Shohreh F; Brickley, Elizabeth B; Li, Zhigang et al. (2017) Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort. Environ Res 156:426-433
Thomas, Duncan C (2017) What Does ""Precision Medicine"" Have to Say About Prevention? Epidemiology 28:479-483
Pomatto, Laura C D; Carney, Caroline; Shen, Brenda et al. (2017) The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress. Curr Biol 27:1-15
Manrai, Arjun K; Cui, Yuxia; Bushel, Pierre R et al. (2017) Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health. Annu Rev Public Health 38:279-294
Gauderman, W James; Mukherjee, Bhramar; Aschard, Hugues et al. (2017) Update on the State of the Science for Analytical Methods for Gene-Environment Interactions. Am J Epidemiol 186:762-770
Muchmore, Patrick; Rappaport, Edward B; Eckel, Sandrah P (2017) Bayesian estimation of physiological parameters governing a dynamic two-compartment model of exhaled nitric oxide. Physiol Rep 5:
Paul, Kimberly C; Sinsheimer, Janet S; Cockburn, Myles et al. (2017) Organophosphate pesticides and PON1 L55M in Parkinson's disease progression. Environ Int 107:75-81

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