The NIEHS Center for Environmental Health in Northern Manhattan (CEHNM) brings together scientists, physicians, epidemiologists, biostatisticians and citizens in a partnership focusing on a central theme that stresses understanding and preventing the environmental components of disease. The 32 Center, investigators work in three disease areas: cancer, respiratory diseases and neurotoxicology/ neurodegenerative diseases. Members seek to identify and study environmental exposures that contribute to the pathophysiology of human disease; communicate these results to other researchers, impacted communities, and the public; and develop strategies for translating these findings to improve public health. Research ranges from basic mechanistic studies to animal models to population studies. Themes are centered around air toxics/bioaerosols, oxidative stress, gene-environment interactions, life course exposures, epigenetics and, our newest theme, climate and health. While much research is focused on a disadvantaged community that receives disproportionally high exposure to hazardous substances in NYC, other projects study effects of environmental exposures around the world. Research is facilitated by four service cores including: (1) Exposure Assessment, (2) Trace Metals, (3) Integrative Health Sciences and (4) Administrative. Flexible Working Groups (Biomass Combustion, Epigenetics, Environmental Determinants of Neurological Disease, Environmental Exposures across the Life Course, Climate and Health) bring together investigators across the disease areas to initiate new areas of collaboration. A successful Pilot Project Program brings in new investigators and ideas. Our Community Outreach and Engagement Core is an active collaboration between Center investigators and West Harlem Environmental Action (WE ACT), our primary community partner. Activities include community forums, national conferences, mentoring of high school students and various educational activities. The Career Development Program enhances the mentoring of junior faculty currently taking place within the CEHNM. An Executive Committee helps the Director administer the program while two Advisory Committees provide additional guidance.

Public Health Relevance

Environmental exposures are known to play an important role in several human diseases. Research being carried out in the CEHNM is defining sources and types of exposures, mechanisms-of action and health effects. The better understanding of environmentally related disease will lead to its prevention.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
Program Officer
Thompson, Claudia L
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Columbia University (N.Y.)
Public Health & Prev Medicine
Schools of Public Health
New York
United States
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Reynolds, Lindsay M; Magid, Hoda S; Chi, Gloria C et al. (2017) Secondhand Tobacco Smoke Exposure Associations With DNA Methylation of the Aryl Hydrocarbon Receptor Repressor. Nicotine Tob Res 19:442-451
Burris, Heather H; Baccarelli, Andrea A (2017) Air pollution and in utero programming of poor fetal growth. Epigenomics 9:213-216
Colicino, Elena; Wilson, Ander; Frisardi, Maria Chiara et al. (2017) Telomere Length, Long-Term Black Carbon Exposure, and Cognitive Function in a Cohort of Older Men: The VA Normative Aging Study. Environ Health Perspect 125:76-81
Liu, Miaomiao; Huang, Yining; Ma, Zongwei et al. (2017) Spatial and temporal trends in the mortality burden of air pollution in China: 2004-2012. Environ Int 98:75-81
Miller, Rachel L; Zhang, Hanjie; Jezioro, Jacqueline et al. (2017) Reduced mouse allergen is associated with epigenetic changes in regulatory genes, but not mouse sensitization, in asthmatic children. Environ Res 156:619-624
Kioumourtzoglou, Marianthi-Anna; Power, Melinda C; Hart, Jaime E et al. (2017) The Association Between Air Pollution and Onset of Depression Among Middle-Aged and Older Women. Am J Epidemiol 185:801-809
Lee, Joan; Kalia, Vrinda; Perera, Frederica et al. (2017) Prenatal airborne polycyclic aromatic hydrocarbon exposure, LINE1 methylation and child development in a Chinese cohort. Environ Int 99:315-320
Parada Jr, Humberto; Steck, Susan E; Cleveland, Rebecca J et al. (2017) Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence. Ann Epidemiol 27:208-214.e1
Pei, Sen; Shaman, Jeffrey (2017) Counteracting structural errors in ensemble forecast of influenza outbreaks. Nat Commun 8:925
Chen, Kai; Zhou, Lian; Chen, Xiaodong et al. (2017) Acute effect of ozone exposure on daily mortality in seven cities of Jiangsu Province, China: No clear evidence for threshold. Environ Res 155:235-241

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