The Pilot Projects Program (PPP) is an important benefit of CEHS membership. Since the inception of the Center, the PPP has been viewed as a central activity of the Center. The mission of the PPP is to provide seed money to Center members to enhance their ability to obtain outside funding In a new innovative area of environmentally related research, preferably In a multi-disciplinary context. As described below, the program has been used primarily to foster the development of: (1) junior faculty who are developing a research program in an area of environmental health research of relevance to the Center;(2) to assist senior faculty members shift to new areas of environment research;(3) attract new investigators to apply their expertise to an environmentally related health problem;and (4) physician/scientists.
These aims have driven our annual Program, including the announcements of the availability of the pilot project awards, the application review process, as well as the selection of pilot project awardees. The ultimate goal of the pilot project program is to invest in and support the development of investigators that will generate external funding to address significant problems in environmental health. To this end, our award recipients have been very successful in obtaining funding for applications subsequently submitted to external agencies, usually utilizing data generated as part of the PPP, despite the modest amount of each single pilot project award (see below). The Center's investment of $1,294,297 (for years 2001 through 2008) has yielded more than 28 times that amount of direct funding (= $36,931,902) to PPP Awardees from external sources, as shown below. In addition, publications resulting from the PPP awards continue to increase (n = 56), also shown below. These successes of our PPP investigators are reviewed below under the section on """"""""Accomplishments.""""""""

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Parada Jr, Humberto; Sun, Xuezheng; Fleming, Jodie M et al. (2017) Race-associated biological differences among luminal A and basal-like breast cancers in the Carolina Breast Cancer Study. Breast Cancer Res 19:131
Conti, David V; Wang, Kan; Sheng, Xin et al. (2017) Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. J Natl Cancer Inst 109:
Kechele, Daniel O; Blue, R Eric; Zwarycz, Bailey et al. (2017) Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest 127:593-607
Bower, Jacquelyn J; Vance, Leah D; Psioda, Matthew et al. (2017) Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells. NPJ Breast Cancer 3:9
Mauguen, Audrey; Zabor, Emily C; Thomas, Nancy E et al. (2017) Defining Cancer Subtypes With Distinctive Etiologic Profiles: An Application to the Epidemiology of Melanoma. J Am Stat Assoc 112:54-63
Huo, Dezheng; Hu, Hai; Rhie, Suhn K et al. (2017) Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas. JAMA Oncol 3:1654-1662
Ballantine, Jami L; Carlson, Jenna C; Ferreira Zandoná, Andrea G et al. (2017) Exploring the genomic basis of early childhood caries: a pilot study. Int J Paediatr Dent :
Bu, Ruofei; Balakrishnan, Santosh; Iftimia, Nicusor et al. (2017) Airway compliance measured by anatomic optical coherence tomography. Biomed Opt Express 8:2195-2209
Beard, John D; Engel, Lawrence S; Richardson, David B et al. (2017) Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis survival. PLoS One 12:e0185751
McEachran, Andrew D; Shea, Damian; Nichols, Elizabeth Guthrie (2017) Pharmaceuticals in a temperate forest-water reuse system. Sci Total Environ 581-582:705-714

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