The Pilot Projects Program (PPP) is an important benefit of CEHS membership. Since the inception of the Center, the PPP has been viewed as a central activity of the Center. The mission of the PPP is to provide seed money to Center members to enhance their ability to obtain outside funding In a new innovative area of environmentally related research, preferably In a multi-disciplinary context. As described below, the program has been used primarily to foster the development of: (1) junior faculty who are developing a research program in an area of environmental health research of relevance to the Center;(2) to assist senior faculty members shift to new areas of environment research;(3) attract new investigators to apply their expertise to an environmentally related health problem;and (4) physician/scientists.
These aims have driven our annual Program, including the announcements of the availability of the pilot project awards, the application review process, as well as the selection of pilot project awardees. The ultimate goal of the pilot project program is to invest in and support the development of investigators that will generate external funding to address significant problems in environmental health. To this end, our award recipients have been very successful in obtaining funding for applications subsequently submitted to external agencies, usually utilizing data generated as part of the PPP, despite the modest amount of each single pilot project award (see below). The Center's investment of $1,294,297 (for years 2001 through 2008) has yielded more than 28 times that amount of direct funding (= $36,931,902) to PPP Awardees from external sources, as shown below. In addition, publications resulting from the PPP awards continue to increase (n = 56), also shown below. These successes of our PPP investigators are reviewed below under the section on "Accomplishments."

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Bair, Eric; Gaynor, Sheila; Slade, Gary D et al. (2016) Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: the OPPERA study. Pain 157:1266-78
Hashimoto, Kiyohiro; Sharma, Vyom; Sasanuma, Hiroyuki et al. (2016) Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells. Oncotarget :
Warren, Joshua L; Perez-Heydrich, Carolina; Burgert, Clara R et al. (2016) Influence of Demographic and Health Survey Point Displacements on Point-in-Polygon Analyses. Spat Demogr 4:117-133
Pitman, Catherine L; Brereton, Kelsey R; Miller, Alexander J M (2016) Aqueous Hydricity of Late Metal Catalysts as a Continuum Tuned by Ligands and the Medium. J Am Chem Soc 138:2252-60
Buckley, Jessie P; Engel, Stephanie M; Braun, Joseph M et al. (2016) Prenatal Phthalate Exposures and Body Mass Index Among 4- to 7-Year-old Children: A Pooled Analysis. Epidemiology 27:449-58
Meyer, Katie A; Guilkey, David K; Tien, Hsiao-Chuen et al. (2016) Instrumental-Variables Simultaneous Equations Model of Physical Activity and Body Mass Index: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Epidemiol 184:465-76
White, Alexandra J; Bradshaw, Patrick T; Herring, Amy H et al. (2016) Exposure to multiple sources of polycyclic aromatic hydrocarbons and breast cancer incidence. Environ Int 89-90:185-92
Fannin, R D; Gerrish, K; Sieber, S O et al. (2016) Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther 99:432-41
Taylor, Nicholas J; Thomas, Nancy E; Anton-Culver, Hoda et al. (2016) Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma. Int J Cancer 139:1217-22
Wyss, Annah B; Hashibe, Mia; Lee, Yuan-Chin Amy et al. (2016) Smokeless Tobacco Use and the Risk of Head and Neck Cancer: Pooled Analysis of US Studies in the INHANCE Consortium. Am J Epidemiol :

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