The overall mission ofthe University of Michigan NIEHS Center is to use novel multi-disciplinary translational research to better understand the impact of environmental exposures on selected disease processes (Fiaure 1-1) throuah mechanisms involving epigenetic modifications during vulnerable stages of life. In direct response to one of our major critiques, our Center proposal has been focused on operations of three Research Teams established over the past year concentrating on Epigenetic Regulation, Oxidative Stress, and Endocrine Disruptors. The Center will capitalize on several cores: an Exposure Assessment Core with experienced teams of scientists skilled in developing and applying methodologies for assessing exposure to metals, particles, organics, nutrients, and other potential external environmental hazards;a Biological Responses Core that has developed a state-of-the-art epigenetics translational research faculty and laboratory that will serve also as a gateway to gene expression, proteomics, and metabolomics facilities and capabilities at the University of Michigan;an Environmental Statistics Core of faculty specifically experienced with environmental epidemiology and gene-environment interactions;a Bioinformatics Core with specific expertise in genomics, epigenomics, and high-dimensional Integrative informatics involving 'omics data;and an Integrated Health Sciences Core that will provide (a) an innovative web-based interactive """"""""kiosk"""""""" for accessing detailed information on our resources and step-by-step guidance on services, pricing and access;and (b) """"""""translational consultation services"""""""" by the Core's key personnel in consultation with other Core Leaders and Center Members on designing studies, connecting investigators across disciplines, utilizing our cores, and gaining access to our rich resources of biorepository material. Finally, we have built an experienced Community Outreach and Education Core upon the extensive ties our team has already established in Southeast Michigan to address the importance of early life exposures as determinants of health as our diverse portfolio of Center-related work progresses.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
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University of Michigan Ann Arbor
Ann Arbor
United States
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Ding, Ning; Wang, Xin; Weisskopf, Marc G et al. (2016) Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. PLoS One 11:e0161472
Li, Hong-Dong; Omenn, Gilbert S; Guan, Yuanfang (2016) A proteogenomic approach to understand splice isoform functions through sequence and expression-based computational modeling. Brief Bioinform 17:1024-1031
Ferguson, Kelly K; Cantonwine, David E; McElrath, Thomas F et al. (2016) Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy. Reprod Toxicol 66:93-98
Huang, Siying; Hu, Howard; Sánchez, Brisa N et al. (2016) Childhood Blood Lead Levels and Symptoms of Attention Deficit Hyperactivity Disorder (ADHD): A Cross-Sectional Study of Mexican Children. Environ Health Perspect 124:868-74
Sampson, Natalie R; Tetteh, Myra M; Schulz, Amy J et al. (2016) Multidirectional Translation of Environmental Health Science in Community Settings: The Case of Oxidative Stress Pathways. Prog Community Health Partnersh 10:275-84
Ferguson, Kelly K; Meeker, John D; Cantonwine, David E et al. (2016) Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environ Int 94:531-7
Zhang, Zhenzhen; O'Neill, Marie S; Sánchez, Brisa N (2016) Using a latent variable model with non-constant factor loadings to examine PM2.5 constituents related to secondary inorganic aerosols. Stat Modelling 16:91-113
Virani, Shama; Rentschler, Katie M; Nishijo, Muneko et al. (2016) DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status. Chemosphere 145:284-90
Goodrich, Jaclyn M; Chou, Hwai-Nan; Gruninger, Stephen E et al. (2016) Exposures of dental professionals to elemental mercury and methylmercury. J Expo Sci Environ Epidemiol 26:78-85
Omenn, Gilbert S; Lane, Lydie; Lundberg, Emma K et al. (2016) Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications. J Proteome Res 15:3951-3960

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