The vision of the HERCULES P30 (Health and Exposome Research Center: Understanding Lifetime Exposures) is for the exposome to gain equal footing to the genome in clinical and public health settings. The investigators believe that the pursuit of this simple and unifying visin will stimulate discovery, promote collaboration, and enhance communication in Environmental Health Sciences at Emory University. The investigators plan to use the P30 mechanism to create an intellectual climate that fosters innovation, collaboration, and progress. Specifically, they plan to enhance collaborative research at Emory, including increasing extramural funding, serving the local and regional community as a source for information on environmental issues, and to make an impact on the national and global level through cutting-edge research. To do this the investigators propose the following specific aims that align with their theme of using exposome-related concepts and approaches to improve human health:
Specific Aim 1 : Provide greater access to exposome-related approaches (systems biology, metabolomics, high throughput toxicology, spatial and temporal statistical models) through cores, pilot funding, and research forums.
Specific Aim 2 : Make major contributions towards the operational definition of the exposome (promoting a culture of team science, pilot funding, pursuing exposome-related research).
Specific Aim 3 : Provide career development activities around innovative and emerging concepts and approaches related to exposome.
Specific Aim 4 : Enhance and expand existing relationships with community partners to facilitate communication of the importance of environmental factors in disease using exposome principles.
Specific Aim 5 : Provide infrastructure and resources to facilitate rapid translation of novel scientific findings ito the development of novel sustainability, prevention or treatment strategies in humans. The organization of the Center is depicted in the HERCULES Logic Model in the strategic vision section. The Executive Committee will be guided by these aims and use the Logic Model to monitor progress of the Center.

Public Health Relevance

Human health and disease is dictated by a combination of genetic and environmental factors. The HERCULES Center is focused on providing a more comprehensive assessment of these environmental influences by utilizing exposome-based concepts and approaches.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
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Emory University
Public Health & Prev Medicine
Schools of Public Health
United States
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Hu, Xin; Chandler, Joshua D; Fernandes, Jolyn et al. (2018) Selenium supplementation prevents metabolic and transcriptomic responses to cadmium in mouse lung. Biochim Biophys Acta Gen Subj :
Jacobson, Melanie H; Howards, Penelope P; Darrow, Lyndsey A et al. (2018) Thyroid hormones and menstrual cycle function in a longitudinal cohort of premenopausal women. Paediatr Perinat Epidemiol 32:225-234
Bettermann, Erika L; Hartman, Terryl J; Easley, Kirk A et al. (2018) Higher Mediterranean Diet Quality Scores and Lower Body Mass Index Are Associated with a Less-Oxidized Plasma Glutathione and Cysteine Redox Status in Adults. J Nutr 148:245-253
Thompson, Jeffrey A; Christensen, Brock C; Marsit, Carmen J (2018) Methylation-to-Expression Feature Models of Breast Cancer Accurately Predict Overall Survival, Distant-Recurrence Free Survival, and Pathologic Complete Response in Multiple Cohorts. Sci Rep 8:5190
Everson, Todd M; Marsit, Carmen J (2018) Integrating -Omics Approaches into Human Population-Based Studies of Prenatal and Early-Life Exposures. Curr Environ Health Rep 5:328-337
Ladva, Chandresh Nanji; Golan, Rachel; Liang, Donghai et al. (2018) Particulate metal exposures induce plasma metabolome changes in a commuter panel study. PLoS One 13:e0203468
Steves, Alyse N; Bradner, Joshua M; Fowler, Kristen L et al. (2018) Ubiquitous Flame-Retardant Toxicants Impair Spermatogenesis in a Human Stem Cell Model. iScience 3:161-176
Fernandes, Jolyn; Chandler, Joshua D; Liu, Ken H et al. (2018) Putrescine as indicator of manganese neurotoxicity: Dose-response study in human SH-SY5Y cells. Food Chem Toxicol 116:272-280
Go, Young-Mi; Fernandes, Jolyn; Hu, Xin et al. (2018) Mitochondrial network responses in oxidative physiology and disease. Free Radic Biol Med 116:31-40
Uppal, Karan; Ma, Chunyu; Go, Young-Mi et al. (2018) xMWAS: a data-driven integration and differential network analysis tool. Bioinformatics 34:701-702

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