The Systems Biology Core, directed by Eberhard Voit, is composed of an educational component and a service component. The goal of the core is to educate HERCULES investigators on how systems biology approaches can help generate data that can be used in higher-level exposome models. The service component will provide bioinformatic, biostatistical, and systems biology support for all HERCULES investigators. The Integrated Health Sciences Facility Core, directed by Dean Jones, will provide three central functions within the Center, support of clinical research services, personalized exposure surveillance using a top-down high-resolution metabolomics method and targeted exposure analysis using mass spectrometry, immunoassay and chemical sensor methods. The core will facilitate translational and clinical studies by providing access and expertise with several well-characterized human/clinical populations. The IHSFC will act at the interface of the exposome and clinical and public health practice.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
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Emory University
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Go, Young-Mi; Walker, Douglas I; Soltow, Quinlyn A et al. (2015) Metabolome-wide association study of phenylalanine in plasma of common marmosets. Amino Acids 47:589-601
Miller, Gary W; Jones, Dean P (2014) The nature of nurture: refining the definition of the exposome. Toxicol Sci 137:1-2
Taylor, Tonya N; Alter, Shawn P; Wang, Minzheng et al. (2014) Reduced vesicular storage of catecholamines causes progressive degeneration in the locus ceruleus. Neuropharmacology 76 Pt A:97-105
Zhang, Jie; Shen, Heqing; Xu, Weipan et al. (2014) Urinary metabolomics revealed arsenic internal dose-related metabolic alterations: a proof-of-concept study in a Chinese male cohort. Environ Sci Technol 48:12265-74
Frediani, Jennifer K; Jones, Dean P; Tukvadze, Nestan et al. (2014) Plasma metabolomics in human pulmonary tuberculosis disease: a pilot study. PLoS One 9:e108854
Go, Young-Mi; Jones, Dean P (2014) Redox biology: interface of the exposome with the proteome, epigenome and genome. Redox Biol 2:358-60
Darrow, Lyndsey A; Klein, Mitchel; Flanders, W Dana et al. (2014) Air pollution and acute respiratory infections among children 0-4 years of age: an 18-year time-series study. Am J Epidemiol 180:968-77
Romanyuk, Andrey V; Zvezdin, Vasiliy N; Samant, Pradnya et al. (2014) Collection of analytes from microneedle patches. Anal Chem 86:10520-3
Wilson, W Wyatt; Shapiro, Lauren P; Bradner, Joshua M et al. (2014) Developmental exposure to the organochlorine insecticide endosulfan damages the nigrostriatal dopamine system in male offspring. Neurotoxicology 44:279-87
Wilson, W Wyatt; Onyenwe, Wellington; Bradner, Joshua M et al. (2014) Developmental exposure to the organochlorine insecticide endosulfan alters expression of proteins associated with neurotransmission in the frontal cortex. Synapse 68:485-97

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