The mission of the IHFSC Is to facilitate translation and integration of basic science research on environmental exposures into population and personalized health applications, with an emphasis on the impact of exposures on complex biological systems that change dynamically over time. This mission is driven by the overall theme of HERCULES to use exposome-based concepts and approaches to improve human health. A key aspect of the ISHFC is to operationalize exposome-related research and is primarily designed to provide access to, tools and research approaches for clinical and epidemiology research in environmental health. The definitions and implications of the exposome in environmental health sciences remain at a relatively early stage of development, both nationally and internationally. The IHFSC leadership (Jones, Barr, Ziegler) are active in workshops, symposia, and society activities promoting development of exposome-related research. As the IHFSC pursues its mission within HERCULES (Fig G.1) to help operationalize exposome-related research, they will work closely with faculty affiliated with: 1) the Systems Biology Core to enhance utilization and development of exposome-related tools, 2) the Career Development Program to enhance training opportunities in key exposure science technologies and environmental health approaches, 3) the Community Outreach and Engagement Core (COEC) and the Administrative Core to enhance global understanding of the exposome-related concepts and research and their importance in human health and environmental sustainability, and 4) the Pilot Project Program to facilitate translation and integration of exposome-related research tools and concepts into novel and competitive new research projects. This will be done by the IHFSC through 3 major components, universal exposure surveillance (Jones), targeted exposure analyses (Barr), and clinical research services (Ziegler) (Fig G. 1). This builds upon existing bench-to-bedside research in environmental health sciences, anchored by Dr Barr's expert capabilities in exposure science, Dr Jones's universal exposure surveillance method [1], and Dr Ziegler clinical research expertise and links to resources that capitalize on access to well-characterized patients and control subjects. The Core leaders have established local, national and international research leadership in exposure science, quantitative biology, nutrition, and clinical and translational research, have been active in development of exposome-related research and are well- positioned to lead efforts to enhance and facilitate the NIEHS mission in environmental health.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
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Emory University
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Go, Young-Mi; Walker, Douglas I; Soltow, Quinlyn A et al. (2015) Metabolome-wide association study of phenylalanine in plasma of common marmosets. Amino Acids 47:589-601
Miller, Gary W; Jones, Dean P (2014) The nature of nurture: refining the definition of the exposome. Toxicol Sci 137:1-2
Taylor, Tonya N; Alter, Shawn P; Wang, Minzheng et al. (2014) Reduced vesicular storage of catecholamines causes progressive degeneration in the locus ceruleus. Neuropharmacology 76 Pt A:97-105
Zhang, Jie; Shen, Heqing; Xu, Weipan et al. (2014) Urinary metabolomics revealed arsenic internal dose-related metabolic alterations: a proof-of-concept study in a Chinese male cohort. Environ Sci Technol 48:12265-74
Frediani, Jennifer K; Jones, Dean P; Tukvadze, Nestan et al. (2014) Plasma metabolomics in human pulmonary tuberculosis disease: a pilot study. PLoS One 9:e108854
Go, Young-Mi; Jones, Dean P (2014) Redox biology: interface of the exposome with the proteome, epigenome and genome. Redox Biol 2:358-60
Darrow, Lyndsey A; Klein, Mitchel; Flanders, W Dana et al. (2014) Air pollution and acute respiratory infections among children 0-4 years of age: an 18-year time-series study. Am J Epidemiol 180:968-77
Romanyuk, Andrey V; Zvezdin, Vasiliy N; Samant, Pradnya et al. (2014) Collection of analytes from microneedle patches. Anal Chem 86:10520-3
Wilson, W Wyatt; Shapiro, Lauren P; Bradner, Joshua M et al. (2014) Developmental exposure to the organochlorine insecticide endosulfan damages the nigrostriatal dopamine system in male offspring. Neurotoxicology 44:279-87
Wilson, W Wyatt; Onyenwe, Wellington; Bradner, Joshua M et al. (2014) Developmental exposure to the organochlorine insecticide endosulfan alters expression of proteins associated with neurotransmission in the frontal cortex. Synapse 68:485-97

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