Situated in the heart of Detroit, the Wayne State University Center for Urban Responses to Environmental Stressors (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psychosocial and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in (1) immune disorders, (2) metabolic disease, (3) cancer, and (4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.

Public Health Relevance

The Wayne State University (WSU) 'Center for Urban Responses to Environmental Stressors' (CURES) is focused on establishing a cleaner and healthier living and working environment in the city of Detroit. The CURES Center applies an integrated team approach to understand how exposure to urban environmental chemical and non-chemical stressors affects human health.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
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Environmental Health Sciences Review Committee (EHS)
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Tan, Zhijing; Nie, Song; McDermott, Sean P et al. (2017) Single Amino Acid Variant Profiles of Subpopulations in the MCF-7 Breast Cancer Cell Line. J Proteome Res 16:842-851
Embogama, D Maheeka; Pflum, Mary Kay H (2017) K-BILDS: A Kinase Substrate Discovery Tool. Chembiochem 18:136-141
Nalawansha, Dhanusha A; Gomes, Inosha D; Wambua, Magdalene K et al. (2017) HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation. Cell Chem Biol 24:481-492.e5
Wright, A Michelle; Talia, Yousif R; Aldhalimi, Abir et al. (2017) Kidnapping and Mental Health in Iraqi Refugees: The Role of Resilience. J Immigr Minor Health 19:98-107
Sen, Arko; Gurdziel, Katherine; Liu, Jenney et al. (2017) Smooth, an hnRNP-L Homolog, Might Decrease Mitochondrial Metabolism by Post-Transcriptional Regulation of Isocitrate Dehydrogenase (Idh) and Other Metabolic Genes in the Sub-Acute Phase of Traumatic Brain Injury. Front Genet 8:175
Qu, Wen; Gurdziel, Katherine; Pique-Regi, Roger et al. (2017) Identification of Splicing Quantitative Trait Loci (sQTL) in Drosophila melanogaster with Developmental Lead (Pb2+) Exposure. Front Genet 8:145
Parker, Graham C; Carruthers, Nicholas J; Gratsch, Theresa et al. (2017) Proteomic profile of embryonic stem cells with low survival motor neuron protein is consistent with developmental dysfunction. J Neural Transm (Vienna) 124:13-23
Carruthers, Nicholas J; Stemmer, Paul M; Chen, Ben et al. (2017) Phosphoproteome and transcription factor activity profiling identify actions of the anti-inflammatory agent UTL-5g in LPS stimulated RAW 264.7 cells including disrupting actin remodeling and STAT-3 activation. Eur J Pharmacol 811:66-73
Iadipaolo, Allesandra S; Marusak, Hilary A; Sala-Hamrick, Kelsey et al. (2017) Behavioral activation sensitivity and default mode network-subgenual cingulate cortex connectivity in youth. Behav Brain Res 333:135-141
Li, Lingzhi; Chen, Fei (2017) Arsenic and SUMO wrestling in protein modification. Cell Cycle 16:913-914

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