The primary goal of the Integrative Health Sciences Facility Core (IHSFC) is to facilitate translation of CTEHR research in the basic sciences into human population and clinical studies, and to """"""""reverse translate"""""""" findings from human studies into new hypothesis-driven laboratory-based research. To enhance our understanding of the environmental basis of disease, and optimize detection, prevention and/or management of diseases induced or exacerbated by environmental exposures, the IHSFC will provide: ? Prioritized access to tissue repositories and development of protocols for human research with Virtual Repository and Protocol Development (VRPD) service; ? Characterization and metagenomic profiling of human microbiota and generation of humanized mice with a Microbiome and Gnotobiotic (MG) resource and ? Access to metabolic profiling of tissues and individuals with Metabolic Phenotyping (MP) capability. The IHSFC will provide """"""""Translational Navigators"""""""" for Center members, who will contribute unique expertise and facilitate effective utilization of IHSFC resources by CTEHR investigators. Translational Navigators will also direct and facilitate """"""""priority"""""""" access to IHSFC resources by Center members. In order to accomplish Core goals, we propose the following Specific Aims:
Aim 1. Provide services and access to instrumentation and technologies through services and resources that foster (reverse) translation of basic science into public health research, including epidemiology, prevention and intervention studies as they relate to environmental exposures and diseases.
Aim 2. Further support the educational mission of the CTEHR by providing training and career development for Center members and trainees in collaboration with the Career Development Program.
Aim 3. Enhance and """"""""navigate"""""""" partnerships between researchers and the community that impact on conducting clinical and public health research through linkages with the Community Outreach and Engagement Core (COEC). The IHSFC will be a catalyst for innovation and provide unique resources to CTEHR members, leveraging well- equipped laboratories, established infrastructure, sample archives and expertise to facilitate EHS research.
Program Narrative - Integrative Health Sciences Facility Core The IHSFC will facilitate translation of basic science research into human population studies, and to reverse translate findings from human and clinical studies into new hypothesis-driven laboratory-based research.
|McQueen, Cole M; Schmitt, Emily E; Sarkar, Tapasree R et al. (2018) PER2 regulation of mammary gland development. Development 145:|
|Kim, Eunjoo; Wright, Gus A; Zoh, Roger S et al. (2018) Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model. Eur J Cancer Prev :|
|Luo, Yu-Syuan; Furuya, Shinji; Chiu, Weihsueh et al. (2018) Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. J Toxicol Environ Health A 81:37-52|
|Jonker, Renate; Deutz, Nicolaas E P; Schols, Annemie M W J et al. (2018) Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein. Clin Nutr :|
|Pogribny, Igor P; Dreval, Kostiantyn; Kindrat, Iryna et al. (2018) Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma. FASEB J 32:1591-1601|
|Jonker, Renate; Deutz, Nicolaas E P; Ligthart-Melis, Gerdien C et al. (2018) Preserved anabolic threshold and capacity as estimated by a novel stable tracer approach suggests no anabolic resistance or increased requirements in weight stable COPD patients. Clin Nutr :|
|Deutz, Nicolaas E P; Thaden, John J; Ten Have, Gabriella A M et al. (2018) Metabolic phenotyping using kinetic measurements in young and older healthy adults. Metabolism 78:167-178|
|Lacey, Alexandra; Hedrick, Erik; Cheng, Yating et al. (2018) Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma. Mol Cancer Ther 17:2756-2766|
|Fuentes, Natividad R; Kim, Eunjoo; Fan, Yang-Yi et al. (2018) Omega-3 fatty acids, membrane remodeling and cancer prevention. Mol Aspects Med 64:79-91|
|Engelen, Mariëlle P K J; Deutz, Nicolaas E P (2018) Is ?-hydroxy ?-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations? Curr Opin Clin Nutr Metab Care 21:207-213|
Showing the most recent 10 out of 166 publications