The overall goal of the Career Development Program (CDP) of the CTEHR is to support training and professional development of new and transitioning environmental health investigators and physician scientists. Because the most important, scientifically interesting and challenging questions in EHS research are embedded at the interface of multiple disciplines, the CDP will play a key role in helping to facilitate the generation of new scientific knowledge, technical capabilities, and formation of inter- and trans-disciplinary groups to develop the future EHS research workforce. The approach will focus on the continuum of career development from post-doctoral fellow to junior faculty and clinician scientists to established scientists pursuing environmental health research questions. In order to accomplish this goal, we will carry out the following Specific Aims:
Aim 1. Attract and engage a diverse group of junior investigators to enhance pursuit of EHS research through development of a formal mentoring program, targeted pilot project opportunities and access to advanced technology through CTEHR Facility Cores.
Aim 2. Target and mentor selected post-doctoral trainees to provide focused mentoring and foster development of successful NIH K awards.
Aim 3. Develop an Inter-Center Resource Alliance and Mentored Partnership Program to enhance inter- center collaboration and expand EHS research.
Aim 4. Develop, in collaboration with the COEC and IHSFC, "Inreach" activities to provide information, strategies and expertise on engaging communities in community-based participatory and epidemiologic research. The CDP is in a unique position to accomplish these aims, due to connections with the CTEHR Thematic Focus Areas, and shared leadership with the Advanced Imaging, Quantitative Biology, Targeted Genomics and Integrated Health Sciences Facility Cores and the COEC.
Program Narrative - Career Development Program (CDP) The Career Development Program (CDP) of the CTEHR will support the training and professional development of the next generation of environmental health scientists. The CDP will play a key role in helping to facilitate the generation of scientific knowledge, new technical capability, and ways to work as interdisciplinary groups in developing the future interdisciplinary environmental health sciences research workforce. The CDP is uniquely positioned to accomplish this due to its involvement in the research themes within the Center and its close association and shared leadership with the Advanced Imaging, Quantitative Biology, Targeted Genomics, and Integrated Health Sciences Facility Cores and the COEC.
|Phillips, Tracie D; Richardson, Molly; Cheng, Yi-Shing Lisa et al. (2015) Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol 89:967-77|
|Lee, Syng-Ook; Li, Xi; Hedrick, Erik et al. (2014) Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Mol Endocrinol 28:1729-39|
|Nair, Vijayalekshmi; Sreevalsan, Sandeep; Basha, Riyaz et al. (2014) Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors. J Biol Chem 289:27692-701|
|Jutooru, Indira; Guthrie, Aaron S; Chadalapaka, Gayathri et al. (2014) Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Mol Cell Biol 34:2382-95|
|Kang, Y; Nian, H; Rajendran, P et al. (2014) HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Cell Death Dis 5:e1476|
|Stossi, Fabio; Bolt, Michael J; Ashcroft, Felicity J et al. (2014) Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays. Chem Biol 21:743-53|
|Lingappan, Krithika; Jiang, Weiwu; Wang, Lihua et al. (2014) Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci 141:68-77|
|Allen, M Jeannie; Fan, Yang-Yi; Monk, Jennifer M et al. (2014) n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4? T cells. J Nutr 144:1306-13|
|Knight, Jason M; Davidson, Laurie A; Herman, Damir et al. (2014) Non-invasive analysis of intestinal development in preterm and term infants using RNA-Sequencing. Sci Rep 4:5453|