The mission of Mount Sinai's Transdisciplinary P30 Center on Early Environmental Exposures is to accelerate team science based research utilizing life course?informed models of health. The Biostatistics and Bioinformatics Facility Core (BBFC) plays a key role in that mission by modeling complex, sometimes novel, exposure and phenotype data generated by center members across a wide variety of study types (basic, clinical, epidemiologic) while focusing on developing methods to better address our Center's research themes (multiple exposures/mixtures, stress-chemical interactions, and sex specific effects of environmental exposure). The data structures we emphasize in this Center are multi-dimensional and complex?not simple, single exposures related to a single health outcome. While we offer standard data analytic services (e.g., linear models, longitudinal mixed effects models, power calculations, study analysis planning) the statistical methods and study designs needed for analyzing the complex, high-dimensional data that arise in much of our Center's work are still relatively new and require knowledge of advanced statistical techniques and the ability to curate and interpret complex biologic data ? expertise maintained by the faculty of the BBFC. Core faculty and researchers engage in research motivated by questions and methodological challenges that arise from center collaborations and innovations by our Center Cores. For example, our Center's unique core facility services, such as the tooth biomarker that reconstruct past chemical exposure (described in the Integrated Health Sciences Facility Core) and the operant test chamber for multiple domains of executive functioning (detailed in the Phenotyping and Environmental Modifiers Facility Core) generated the need to create novel data analytical approaches that harness the full potential of these innovative measures. Core faculty and staff provide statistical and bioinformatics training for postdoctoral fellows working on environmental health sciences (EHS) related projects. Providing such services via a core facility allows the P30 Center to build and maintain specialized resources (e.g., expertise in measuring and advanced statistical methods related to evaluation of environmental mixtures). Thus, to support the overall goals of the P30 Center, the BBFC proposes the following specific aims: (1) to ensure that Center projects are grounded in sound biostatistical/bioinformatics principles and use state-of-the-art methods for design and analysis of EHS data; (2) to conduct mission-related biostatistical/bioinformatics methods research for further quality assurance of all research and data analysis methods; and (3) to assist in the training of biostatistical/bioinformatics principles and analysis methods to Center investigators, fellows and post-doctoral trainees.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES023515-05
Application #
9486453
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Horton, Megan K; Hsu, Leon; Claus Henn, Birgit et al. (2018) Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior. Environ Int 121:148-158
Carter, R Colin; Chen, Jia; Li, Qian et al. (2018) Alcohol-Related Alterations in Placental Imprinted Gene Expression in Humans Mediate Effects of Prenatal Alcohol Exposure on Postnatal Growth. Alcohol Clin Exp Res :
Flom, Julie D; Chiu, Yueh-Hsiu Mathilda; Tamayo-Ortiz, Marcela et al. (2018) Subconstructs of the Edinburgh Postpartum Depression Scale in a postpartum sample in Mexico City. J Affect Disord 238:142-146
Sheffield, Perry E; Speranza, Rosa; Chiu, Yueh-Hsiu Mathilda et al. (2018) Association between particulate air pollution exposure during pregnancy and postpartum maternal psychological functioning. PLoS One 13:e0195267
Smith, Milo R; Yevoo, Priscilla; Sadahiro, Masato et al. (2018) Integrative bioinformatics identifies postnatal lead (Pb) exposure disrupts developmental cortical plasticity. Sci Rep 8:16388
Stroustrup, Annemarie; Bragg, Jennifer B; Busgang, Stefanie A et al. (2018) Sources of clinically significant neonatal intensive care unit phthalate exposure. J Expo Sci Environ Epidemiol :
Gutiérrez-Avila, Iván; Rojas-Bracho, Leonora; Riojas-Rodríguez, Horacio et al. (2018) Cardiovascular and Cerebrovascular Mortality Associated With Acute Exposure to PM2.5 in Mexico City. Stroke 49:1734-1736
Parada Jr, Humberto; Gammon, Marilie D; Chen, Jia et al. (2018) Urinary Phthalate Metabolite Concentrations and Breast Cancer Incidence and Survival following Breast Cancer: The Long Island Breast Cancer Study Project. Environ Health Perspect 126:047013
Zhang, W; Li, Q; Deyssenroth, M et al. (2018) Timing of prenatal exposure to trauma and altered placental expressions of hypothalamic-pituitary-adrenal axis genes and genes driving neurodevelopment. J Neuroendocrinol 30:e12581
Lee, Alison; Leon Hsu, Hsiao-Hsien; Mathilda Chiu, Yueh-Hsiu et al. (2018) Prenatal fine particulate exposure and early childhood asthma: Effect of maternal stress and fetal sex. J Allergy Clin Immunol 141:1880-1886

Showing the most recent 10 out of 289 publications