SYSTEMS TECHNOLOGIES CORE (STC) ABSTRACT The goal of the Systems Technologies Core (STC) is to furnish members of the Center for Human Health and the Environment (CHHE) with a range of analytical methodologies and bioinformatics support to paint an integrative, mechanistic picture of the underlying effects of environmental exposures on human health. The STC is composed of three Sections each with expertise and instrumentation spanning genomic, proteomic, and metabolomic technologies as well as dedicated bioinformatic support. The STC will leverage an existing core at NC State and establish a new collaboration to provide genomic and metabolomic technologies to CHHE members, respectively. These services will be complemented with studies in proteomics by the creation of a new Proteomics Section. With these diverse analytical capabilities combined with integrated bioinformatics support through a single portal, the STC will provide a powerful resource to CHHE members to aid in the elucidation of the critical mechanisms through which environmental exposures influence disease etiologies.
The underlying mechanisms at which environmental exposures influence disease remain largely unknown but are associated with changes in biological processes due to modifications in gene expression, protein function, and metabolism. The Systems Technologies Core equips investigators with a powerful set of diverse analytical technologies and expertise to uncover the mechanisms that are disrupted by environmental exposures and their relationship to human diseases.
| Cowley, Michael; Skaar, David A; Jima, Dereje D et al. (2018) Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children. Environ Health Perspect 126:037003 |
| Planchart, Antonio; Green, Adrian; Hoyo, Cathrine et al. (2018) Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies. Curr Environ Health Rep 5:110-124 |
| Schechter, Julia C; Fuemmeler, Bernard F; Hoyo, Cathrine et al. (2018) Impact of Smoking Ban on Passive Smoke Exposure in Pregnant Non-Smokers in the Southeastern United States. Int J Environ Res Public Health 15: |
| Felix, Janine F; Joubert, Bonnie R; Baccarelli, Andrea A et al. (2018) Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. Int J Epidemiol 47:22-23u |
| Duke, Katherine S; Thompson, Elizabeth A; Ihrie, Mark D et al. (2018) Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes. Nanotoxicology :1-17 |
| Mahapatra, Debabrata; Franzosa, Jill A; Roell, Kyle et al. (2018) Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays. Sci Rep 8:8883 |
| Rock, Kylie D; Patisaul, Heather B (2018) Environmental Mechanisms of Neurodevelopmental Toxicity. Curr Environ Health Rep 5:145-157 |
| Patisaul, Heather B; Fenton, Suzanne E; Aylor, David (2018) Animal models of endocrine disruption. Best Pract Res Clin Endocrinol Metab 32:283-297 |
| Davis, Allan Peter; Wiegers, Thomas C; Wiegers, Jolene et al. (2018) Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways. Toxicol Sci 165:145-156 |
| LePrevost, Catherine E; Walton, AnnMarie Lee; Thomas, Gayle et al. (2018) Engaging outreach workers in the development of a farmworker health research agenda. Environ Res 165:19-22 |
Showing the most recent 10 out of 118 publications
