1. OVERALL ABSTRACT This is a new submission to establish the ?ChicAgo Center for Health and EnvironmenT (CACHET)? ? the first NIH P30 Environmental Health Sciences Core Center in the Chicago area and a partnership between the University of Chicago (UofC) ? a leading private university in the nation and the University of Illinois at Chicago (UIC) ? the leading public university in Illinois. CACHET will be comprised of 69 members from 18 Departments across 7 colleges/institutes at the two complementary partner Universities. CACHET will promote synergistic, multidisciplinary environmental health research between the clinician, laboratory and population scientists to evaluate, delineate and ultimately reduce environmental health related disparities among residents of Chicago and beyond. The need for a dedicated environmental health research center in Chicago is highlighted by a disproportionate racial/ethnic health imbalance observed for multiple diseases and outcomes. In this context, the CACHET mission is to ?elucidate the biological, social and economic underpinnings between relevant urban environmental exposures and human disease and translate the findings to reduce health inequities within our communities.? As such, our overarching theme is ?Mitigating Disparities in Environmental Health.? To accomplish our mission, CACHET will organize five multidisciplinary focus groups: Air, Water & Soil Pollution- to address diseases related to poor air, soil and/or water quality; Biomarkers of Exposure, Susceptibility and Risk- to elucidate how environmental exposures confer risk for disease due to individual genetic and epigenetic differences; Environmental Carcinogenesis- to elucidate specific mechanisms of environmental effectors that promote cancer; Endocrine and Metabolic Diseases- to determine how environmental exposures act at windows of susceptibility to drive disequilibrium in endocrine and metabolic homeostasis; and Economic and Social Determinants of Environmental Effects and Policy- such that the economic impacts and social factors are considered in assessing exposure mitigation and informing policy. This structure will permit the development of integrated research themes that cut across focus groups, with a particular emphasis on urban issues and racial/ethnic health imbalances. CACHET multidisciplinary research will be supported through four facility cores that will leverage the expertise and facilities from the two institutions. This includes the required Community Outreach and Engagement Core (COEC) and Integrated Health Sciences Facility Core (IHSFC) combined with the Biomarkers Core (BC) and the Statistics & Modeling Facility Core (SMFC) created in response to the research needs of CACHET investigators. CACHET will build capacity in EHS by funding pilot projects and promoting career development in environmental research. Overall, research orchestrated by CACHET will inform the decisions of policy makers and reduce health disparities in Chicago and beyond.
OVERALL NARRATIVE We propose to establish ?ChicAgo Center for Health and EnvironmenT (CACHET)? ? the first NIEHS P30 environmental health sciences core center in the Chicago area. CACHET will promote multidisciplinary environmental health research among clinician, laboratory and population scientists from two Chicago area universities with complementary strengths and structure (one private and one public) to understand, evaluate and ultimately reduce environmental health related disparities among residents of the region and beyond.
|Shaikh, Sabina; Jagai, Jyotsna S; Ashley, Colette et al. (2018) Underutilized and Under Threat: Environmental Policy as a Tool to Address Diabetes Risk. Curr Diab Rep 18:25|
|Bonini, Marcelo G; Sargis, Robert M (2018) Environmental Toxicant Exposures and Type 2 Diabetes Mellitus: Two Interrelated Public Health Problems on the Rise. Curr Opin Toxicol 7:52-59|
|Kirkley, Andrew G; Carmean, Christopher M; Ruiz, Daniel et al. (2018) Arsenic exposure induces glucose intolerance and alters global energy metabolism. Am J Physiol Regul Integr Comp Physiol 314:R294-R303|
|Madrigal, Jessica M; Persky, Victoria; Pappalardo, Andrea et al. (2018) Association of heavy metals with measures of pulmonary function in children and youth: Results from the National Health and Nutrition Examination Survey (NHANES). Environ Int 121:871-878|
|Prins, Gail S; Patisaul, Heather B; Belcher, Scott M et al. (2018) CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems. Basic Clin Pharmacol Toxicol :|
|Hamanaka, Robert B; Mutlu, Gökhan M (2018) Particulate Matter Air Pollution: Effects on the Cardiovascular System. Front Endocrinol (Lausanne) 9:680|
|Rinaldi, J C; Santos, S A A; Colombelli, K T et al. (2018) Maternal protein malnutrition: effects on prostate development and adult disease. J Dev Orig Health Dis 9:361-372|
|Shah, Palak; Trinh, Elaine; Qiang, Lei et al. (2017) Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer. Molecules 22:|
|Hu, Wen-Yang; Hu, Dan-Ping; Xie, Lishi et al. (2017) Isolation and functional interrogation of adult human prostate epithelial stem cells at single cell resolution. Stem Cell Res 23:1-12|
|Prins, Gail S; Ye, Shu-Hua; Birch, Lynn et al. (2017) Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose-Response Analysis. Environ Health Perspect 125:077007|