Abstract

The Vision Research Group housed in the Jules Stein Eye Institute (JSEI) consists of 16 vision scientists with independent NEI funding (including 1 MERIT, 15 R01's, 1 U10 and 2 R03's). Two are participating investigators. Four of the investigators held MERIT awards during the last award period. The objective of the Core Grant for Vision Research at the JSEI is to provide a critically needed infrastructure to support the research of this talented group of scientists, whose common goal is to increase basic knowledge of the visual system and its disorders. To achieve this objective, personnel and instrument support facilities will be organized according to the following modules: (1) Biochemistry; (2) Microscopy and Imaging; (3) Machine Shop, and (4) Molecular Biology. These modules provide instrumentation commonly used by multiple laboratories, and are essential to the success of the individual projects. Purchase of the state-of-the-art instruments in the modules was made possible by the generosity of the JSEI, and additional support is requested only to maintain these existing modules through instrument service contracts, and to provide the necessary personnel support for user training and routine maintenance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY000331-39
Application #
6890408
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Chin, Hemin R
Project Start
1997-03-01
Project End
2009-02-28
Budget Start
2005-03-01
Budget End
2006-02-28
Support Year
39
Fiscal Year
2005
Total Cost
$453,316
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Kintzer, Alexander F; Green, Evan M; Dominik, Pawel K et al. (2018) Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc Natl Acad Sci U S A 115:E9095-E9104
Bergdoll, Lucie A; Lerch, Michael T; Patrick, John W et al. (2018) Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Proc Natl Acad Sci U S A 115:E172-E179
Vahedi, Farnoosh; Chung, Doug D; Gee, Katherine M et al. (2018) Epithelial Recurrent Erosion Dystrophy Secondary to COL17A1 c.3156C>T Mutation in a Non-white Family. Cornea 37:909-911
Zhang, Xiang-Mei; Hashimoto, Takao; Tang, Ronald et al. (2018) Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. Sci Rep 8:6823
Chaudhuri, Zia; Demer, Joseph L (2018) Long-term Surgical Outcomes in the Sagging Eye Syndrome. Strabismus 26:6-10
Esteve-Rudd, Julian; Hazim, Roni A; Diemer, Tanja et al. (2018) Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration. Proc Natl Acad Sci U S A 115:5468-5473
Morshedian, Ala; Woodruff, Michael L; Fain, Gordon L (2018) Role of recoverin in rod photoreceptor light adaptation. J Physiol 596:1513-1526
Glasgow, Ben J; Abduragimov, Adil R (2018) Interaction of ceramides and tear lipocalin. Biochim Biophys Acta Mol Cell Biol Lipids 1863:399-408
Demer, Joseph L (2018) Knobby Eye Syndrome. Strabismus 26:33-41
Glasgow, Ben J; Abduragimov, Adil R (2018) Ligand binding studies by high speed centrifugal precipitation and linear spectral summation using ultraviolet-visible absorption spectroscopy. MethodsX 5:345-351

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