Investigators who have achieved independent National Eye Institute (NEI) funding will be provided with additional shared support to enhance their own and University of Washington's capability for conducting vision research. Collaborative studies will be facilitated, and scientists will be attracted to research on the visual system by the presence of this shared support. A modular organizational structure will be maintained, with each module devoted to a specific activity that would be impractical or less efficient to support on an individual research grant. Each module will support a service or resource that enhances or facilitates the research efforts of a CORE group of investigators, each having independent funding. Some sharing of resources and services with non-NEI-funded collaborators and with investigators new to vision research will occur. Junior researchers will also have access to these facilities to improve their ability to attain independent NEI funding. Proposed modules include: Biochemistry/Immunology (B/l), Genotyping/Phenotyping (G/P), Morphological Imaging (M/l), and Psychophysics/Physiology (PIP). Areas of investigation include retinal and choroidal diseases, corneal wound healing, corneal diseases, lens and cataract, glaucoma, strabismus, amblyopia, visual processing, and ocular development. Specific disciplines that will be brought to bear on these problems include: behavioral studies, biochemistry, biostatistics, molecular biology, cell biology, proteomics, immunology, microscopy, microbiology, morphometry, neurophysiology, and pathology. This project will elucidate basic mechanisms that underlie the function of the eye and the visual system and apply this knowledge and other information to the solution of problems in vision and ophthalmology. Collaboration among investigators from the University of Washington and elsewhere will be promoted. This proposal will improve the effectiveness of funding available on individual research project grants.
| Schmidt, Brian P; Sabesan, Ramkumar; Tuten, William S et al. (2018) Sensations from a single M-cone depend on the activity of surrounding S-cones. Sci Rep 8:8561 |
| Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540 |
| Leonard, Andrea; Bertero, Alessandro; Powers, Joseph D et al. (2018) Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues. J Mol Cell Cardiol 118:147-158 |
| Arbach, Hannah E; Harland-Dunaway, Marcus; Chang, Jessica K et al. (2018) Extreme nuclear branching in healthy epidermal cells of the Xenopus tail fin. J Cell Sci 131: |
| Pallus, Adam C; Walton, Mark M G; Mustari, Michael J (2018) Activity of near response cells during disconjugate saccades in strabismic monkeys. J Neurophysiol : |
| Kojima, Yoshiko; Soetedjo, Robijanto (2018) Elimination of the error signal in the superior colliculus impairs saccade motor learning. Proc Natl Acad Sci U S A 115:E8987-E8995 |
| Manookin, Michael B; Patterson, Sara S; Linehan, Conor M (2018) Neural Mechanisms Mediating Motion Sensitivity in Parasol Ganglion Cells of the Primate Retina. Neuron 97:1327-1340.e4 |
| Giarmarco, Michelle M; Cleghorn, Whitney M; Hurley, James B et al. (2018) Preparing Fresh Retinal Slices from Adult Zebrafish for Ex Vivo Imaging Experiments. J Vis Exp : |
| Patterson, Emily J; Kalitzeos, Angelos; Kasilian, Melissa et al. (2018) Residual Cone Structure in Patients With X-Linked Cone Opsin Mutations. Invest Ophthalmol Vis Sci 59:4238-4248 |
| Pepple, Kathryn L; Nguyen, Macklin H; Pakzad-Vaezi, Kaivon et al. (2018) RESPONSE OF INFLAMMATORY CYSTOID MACULAR EDEMA TO TREATMENT USING ORAL ACETAZOLAMIDE. Retina : |
Showing the most recent 10 out of 556 publications
