The Wilmer Eye Institute is one of the world leaders in vision research. Its research programs range from basic/fundamental studies on the mechanisms of eye development and vision, to studies of the genetics and pathogenesis of eye disease, to transitional studies, to clinical trials, to epidemiological and international Studies f the worldwide causes of vision loss and disability. Wilmer has been fortunate to have been funded through an NEI Core Grant for Vision Research for over thirty-five years, and this funding has provided the infrastructure and core support for a wide variety of these studies. The support that the Core grant has provided has been a tremendous aid in facilitating Wilmer's diverse research programs and it has also encouraged a number of collaborative research projects. In this competitive renewal application, we are seeking support to continue these essential infrastructure and core activities. We are proposing both continuation of past services, but also modifying and re-directing some cores so as to better adapt to changing research needs, technologies, and priorities. The modules for which funding is requested are cores for Imaging and Microscopy, Biostatistics, Bioinformatics, Animal Modeling, and a new module on Drug Delivery and Nanotechnology. We feel that this new module structure, together with a rigorous administration support structure, will best serve and facilitate the diverse vision research activities at Wilmer and throughout Hopkins.

Public Health Relevance

The proposed research plan is designed to support and facilitate the success and productivity of the many and diverse vision research programs at The Wilmer Eye Institute and throughout the Johns Hopkins School of Medicine, and also to encourage collaborative, innovative, and multi-disciplinary research studies.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
2P30EY001765-39
Application #
8745026
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
Project End
Budget Start
Budget End
Support Year
39
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Flatau, Alison; Solano, Francisco; Idrees, Sana et al. (2016) Measured Changes in Limbal Strain During Simulated Sleep in Face Down Position Using an Instrumented Contact Lens in Healthy Adults and Adults With Glaucoma. JAMA Ophthalmol 134:375-82
Li, Xiaowei; Tzeng, Stephany Y; Liu, Xiaoyan et al. (2016) Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain. Biomaterials 84:157-66
Hu, Ke; Babapoor-Farrokhran, Savalan; Rodrigues, Murilo et al. (2016) Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget 7:7816-28
Antony, Bhavna J; Lang, Andrew; Swingle, Emily K et al. (2016) Simultaneous Segmentation of Retinal Surfaces and Microcystic Macular Edema in SDOCT Volumes. Proc SPIE Int Soc Opt Eng 9784:
Wei, Hong; Xun, Zixian; Granado, Herta et al. (2016) An easy, rapid method to isolate RPE cell protein from the mouse eye. Exp Eye Res 145:450-5
Maisel, Katharina; Reddy, Mihika; Xu, Qingguo et al. (2016) Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo. Nanomedicine (Lond) 11:1337-43
Odden, Jamie L; Mihailovic, Aleksandra; Boland, Michael V et al. (2016) Evaluation of Central and Peripheral Visual Field Concordance in Glaucoma. Invest Ophthalmol Vis Sci 57:2797-804
Nakanishi, Masataka; Grebe, Rhonda; Bhutto, Imran A et al. (2016) Albumen Transport to Bruch's Membrane and RPE by Choriocapillaris Caveolae. Invest Ophthalmol Vis Sci 57:2213-24
Elgogary, Amira; Xu, Qingguo; Poore, Brad et al. (2016) Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A 113:E5328-36
Fu, Jie; Sun, Fengying; Liu, Wenhua et al. (2016) Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. Mol Pharm 13:2987-95

Showing the most recent 10 out of 778 publications