The Wilmer Eye Institute is one of the world leaders in vision research. Its research programs range from basic/fundamental studies on the mechanisms of eye development and vision, to studies of the genetics and pathogenesis of eye disease, to transitional studies, to clinical trials, to epidemiological and international Studies f the worldwide causes of vision loss and disability. Wilmer has been fortunate to have been funded through an NEI Core Grant for Vision Research for over thirty-five years, and this funding has provided the infrastructure and core support for a wide variety of these studies. The support that the Core grant has provided has been a tremendous aid in facilitating Wilmer's diverse research programs and it has also encouraged a number of collaborative research projects. In this competitive renewal application, we are seeking support to continue these essential infrastructure and core activities. We are proposing both continuation of past services, but also modifying and re-directing some cores so as to better adapt to changing research needs, technologies, and priorities. The modules for which funding is requested are cores for Imaging and Microscopy, Biostatistics, Bioinformatics, Animal Modeling, and a new module on Drug Delivery and Nanotechnology. We feel that this new module structure, together with a rigorous administration support structure, will best serve and facilitate the diverse vision research activities at Wilmer and throughout Hopkins.
The proposed research plan is designed to support and facilitate the success and productivity of the many and diverse vision research programs at The Wilmer Eye Institute and throughout the Johns Hopkins School of Medicine, and also to encourage collaborative, innovative, and multi-disciplinary research studies.
|Kim, Jayoung; Sunshine, Joel C; Green, Jordan J (2014) Differential polymer structure tunes mechanism of cellular uptake and transfection routes of poly(*-amino ester) polyplexes in human breast cancer cells. Bioconjug Chem 25:43-51|
|Shen, Jikui; Frye, Maike; Lee, Bonnie L et al. (2014) Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. J Clin Invest 124:4564-76|
|Pease, Mary E; Oglesby, Ericka N; Cone-Kimball, Elizabeth et al. (2014) Scleral permeability varies by mouse strain and is decreased by chronic experimental glaucoma. Invest Ophthalmol Vis Sci 55:2564-73|
|Edwards, Malia M; Rodríguez, José J; Gutierrez-Lanza, Raquel et al. (2014) Retinal macroglia changes in a triple transgenic mouse model of Alzheimer's disease. Exp Eye Res 127:252-60|
|Steinhart, Matthew R; Cone-Kimball, Elizabeth; Nguyen, Cathy et al. (2014) Susceptibility to glaucoma damage related to age and connective tissue mutations in mice. Exp Eye Res 119:54-60|
|McCoy, Allison N; Quigley, Harry A; Wang, Jiangxia et al. (2014) Development and validation of an improved neurological hemifield test to identify chiasmal and postchiasmal lesions by automated perimetry. Invest Ophthalmol Vis Sci 55:1017-23|
|Sluch, Valentin M; Zack, Donald J (2014) Stem cells, retinal ganglion cells and glaucoma. Dev Ophthalmol 53:111-21|
|Zhong, Xiufeng; Gutierrez, Christian; Xue, Tian et al. (2014) Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun 5:4047|
|Sachdeva, Mira M; Cano, Marisol; Handa, James T (2014) Nrf2 signaling is impaired in the aging RPE given an oxidative insult. Exp Eye Res 119:111-4|
|Cano, Marisol; Wang, Lei; Wan, Jun et al. (2014) Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells. Free Radic Biol Med 69:1-14|
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