This is an application for continuing support for a Center for Vision Research in the Department of Ophthalmology. The funds will provide investigators in our Center with shared resources that are vital for efficient research development. Our center is structured into 5 discrete resource/service Modules: Machine Shop, Electronic-Instrumentation, Research Photography-Illustration, Tissue Culture, and Administration. In addition to enhancing the research environment and productivity by providing common centralized services, our center stimulates and facilitates collaborative studies and strives to attract to vision research scientists in other health-related disciplines. Our group consists of 14 principal investigators complemented with several associate investigators and fellows. Research is conducted in several scientific disciplines such as biochemistry, pharmacology, physiology, anatomy, neurology and psychophysics with application to areas of basic and clinical vision research including glaucoma, cataracts; corneal diseases; aqueous humor dynamics, physiology of fluid and electrolyte transport in cornea,lens and ciliary epithelium; role of membrane receptors and prostaglandins in regulation of intraocular pressure; electro-retinogram and visual evoked potentials in eye disease; visual control of the oculomotor system; and morphology and function of central optic pathways. The support of the CORE Center grant is complemented by a strong commitment of the Department and the Mount Sinai Medical Center to excellence in vision research.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001867-18
Application #
2158249
Study Section
Vision Research and Training Committee (VSN)
Project Start
1977-02-01
Project End
1995-06-30
Budget Start
1994-07-01
Budget End
1995-06-30
Support Year
18
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Alvarez, Lawrence J; Zamudio, Aldo C; Candia, Oscar A (2013) Sildenafil stimulates aqueous humor turnover in rabbits. Exp Eye Res 111:67-70
Gerometta, Rosana; Kumar, Sandeep; Shah, Shaily et al. (2013) Reduction of steroid-induced intraocular pressure elevation in sheep by tissue plasminogen activator. Invest Ophthalmol Vis Sci 54:7903-9
Wang, Lingyan; Ly, Christine M; Ko, Chun-Ying et al. (2012) uPA binding to PAI-1 induces corneal myofibroblast differentiation on vitronectin. Invest Ophthalmol Vis Sci 53:4765-75
Gerometta, Rosana; Alvarez, Lawrence J; Candia, Oscar A (2012) Sildenafil accelerates anterior chamber refilling after paracentesis in sheep and rabbits. Invest Ophthalmol Vis Sci 53:565-73
Candia, Oscar A; Mathias, Richard; Gerometta, Rosana (2012) Fluid circulation determined in the isolated bovine lens. Invest Ophthalmol Vis Sci 53:7087-96
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Yakushin, Sergei B; Dai, Mingjia; Raphan, Theodore et al. (2011) Spatial orientation of the angular vestibulo-ocular reflex (aVOR) after semicircular canal plugging and canal nerve section. Exp Brain Res 210:583-94
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Xiao, Youping; Kavanau, Christopher; Bertin, Lauren et al. (2011) The biological basis of a universal constraint on color naming: cone contrasts and the two-way categorization of colors. PLoS One 6:e24994
Crumiller, Marshall; Knight, Bruce; Yu, Yunguo et al. (2011) Estimating the amount of information conveyed by a population of neurons. Front Neurosci 5:90

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