The eye and vision research group of the Medical College of Wisconsin requests containing support for its Core program. Our Core investigators are from six departments and institutes on campus, including a group of collaborating ophthalmologists. We work on most tissues of the eye and the visual system with areas of research interest ranging from proteins structure to brain function. Over the nearly 20 years we have received Core support we have developed and update Modules that efficiently and equitably serve the needs of our group. In addition to helping support our individual research, we also use our Core program to bring our diverse skills together to collaborate on research questions of common interest. With the rapid changes in technology and the increasing need for interdisciplinary research, shared resources and a mechanism to share new skills are becoming progressively more important to research success. The goal of our Core program is therefore to enhance the independent and collaborative investigations of our group by providing both economical infrastructural support for services that cannot be readily supported by individuals, and access to current techniques through experienced Module directors and continuously upgraded instrumentation. Here we request ongoing support for four Modules: Animal Surgery Module, Biochemistry/Molecular Biology Module, Morphology Module, and Tissue Culture Module. We also request support for a new Module devoted to Image Analysis. We believe that continued support for our Modules is critical to enhancing the quality of our research and maintaining the cohesiveness of our group.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001931-22
Application #
2684463
Study Section
Special Emphasis Panel (ZEY1-VSN (02))
Project Start
1977-04-01
Project End
2002-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
22
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Reid, Christopher A; Nettesheim, Emily R; Connor, Thomas B et al. (2018) Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD. Sci Rep 8:11763
Zhang, Hanmeng; Mu, Lianwei; Wang, Dandan et al. (2018) Uncovering a critical period of synaptic imbalance during postnatal development of the rat visual cortex: role of brain-derived neurotrophic factor. J Physiol 596:4511-4536
Lewis, Tylor R; Kundinger, Sean R; Link, Brian A et al. (2018) Kif17 phosphorylation regulates photoreceptor outer segment turnover. BMC Cell Biol 19:25
Huckenpahler, Alison; Wilk, Melissa; Link, Brian et al. (2018) Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina. Adv Exp Med Biol 1074:151-156
Lewis, Tylor R; Zareba, Mariusz; Link, Brian A et al. (2018) Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1. Mol Biol Cell 29:180-190
Lee, Daniel J; Woertz, Erica N; Visotcky, Alexis et al. (2018) The Henle Fiber Layer in Albinism: Comparison to Normal and Relationship to Outer Nuclear Layer Thickness and Foveal Cone Density. Invest Ophthalmol Vis Sci 59:5336-5348
Linderman, Rachel E; Muthiah, Manickam N; Omoba, Sarah B et al. (2018) Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images. Transl Vis Sci Technol 7:20
Vogel, Ryan N; Strampe, Margaret; Fagbemi, Oladipo E et al. (2018) Foveal Development in Infants Treated with Bevacizumab or Laser Photocoagulation for Retinopathy of Prematurity. Ophthalmology 125:444-452
Warren, Clinton C; Young, Jonathon B; Goldberg, Mara R et al. (2018) Findings in Persistent Retinopathy of Prematurity. Ophthalmic Surg Lasers Imaging Retina 49:497-503
Strampe, Margaret R; Huckenpahler, Alison L; Higgins, Brian P et al. (2018) Intraobserver Repeatability and Interobserver Reproducibility of Ellipsoid Zone Measurements in Retinitis Pigmentosa. Transl Vis Sci Technol 7:13

Showing the most recent 10 out of 517 publications