The eye and vision research group at the Medical College of Wisconsin requests continuing support for its Core program. Thirteen Core investigators work on many tissues of the eye and on the visual system, with areas of research ranging from molecular mediators of oxidative stress to imaging of the normal and diseased human retina. Over the nearly 35 years of Core support, the Core Modules have been continuously updated so that they efficiently and equitably serve the needs of the group as its composition and research interests have evolved. In addition to helping support individual research, the Core program also brings together investigators with diverse skills stimulating collaboration on research questions of common interest. With rapid changes in technology and an increasing expectation for interdisciplinary research, shared resources and a mechanism to share new skills have become essential for continued research success. The goal of the Core program is therefore to enhance the independent and collaborative investigations of Core participants by providing both economical infrastructural support for services that cannot be readily supported by individuals, and access to current techniques. The latter is accomplished by knowledgeable. Module directors, experienced staff, continuously upgraded instrumentation, and Core Modules that are designed to work synergistically with one another and with institutional research resources. Support is requested for four updated Modules: Biochemistry-Molecular Biology Module, Cell Culture Module, Morphology & Microscopic Imaging Module, and a significantly redesigned Engineering & Translational Imaging Module that stresses development of novel imaging technologies. Past success of the research group can be partly attributed to the availability of Core-supported Modules. Continued Core support is critical to enhancing the quality of research and to maintaining the cohesiveness and productivity of Medical College eye and vision researchers.

Public Health Relevance

Research supported by the Modules of this Core program has broad relevance for understanding the basic structure, function and development of the cornea, lens and retina. Other supported research addresses the underlying causes and the manifestations of eye diseases especially those affecting the aging retina, including glaucoma and age-related macular degeneration.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
4P30EY001931-40
Application #
9096808
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
1997-04-01
Project End
2017-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
40
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Hirji, Nashila; Georgiou, Michalis; Kalitzeos, Angelos et al. (2018) Longitudinal Assessment of Retinal Structure in Achromatopsia Patients With Long-Term Follow-up. Invest Ophthalmol Vis Sci 59:5735-5744
Krawitz, Brian D; Phillips, Erika; Bavier, Richard D et al. (2018) Parafoveal Nonperfusion Analysis in Diabetic Retinopathy Using Optical Coherence Tomography Angiography. Transl Vis Sci Technol 7:4
Sajdak, Benjamin S; Bell, Brent A; Lewis, Tylor R et al. (2018) Assessment of Outer Retinal Remodeling in the Hibernating 13-Lined Ground Squirrel. Invest Ophthalmol Vis Sci 59:2538-2547
Datta, Shyamtanu; Renwick, Marian; Chau, Viet Q et al. (2018) A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye - Implications for Ocular Gene Therapy. Invest Ophthalmol Vis Sci 59:4909-4920
Mainali, Laxman; O'Brien, William J; Subczynski, Witold K (2018) Detection of cholesterol bilayer domains in intact biological membranes: Methodology development and its application to studies of eye lens fiber cell plasma membranes. Exp Eye Res 178:72-81
Hendee, Kathryn E; Sorokina, Elena A; Muheisen, Sanaa S et al. (2018) PITX2 deficiency and associated human disease: insights from the zebrafish model. Hum Mol Genet 27:1675-1695
Lapierre-Landry, Maryse; Huckenpahler, Alison L; Link, Brian A et al. (2018) Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography. Transl Vis Sci Technol 7:4
Patterson, Emily J; Kalitzeos, Angelos; Kasilian, Melissa et al. (2018) Residual Cone Structure in Patients With X-Linked Cone Opsin Mutations. Invest Ophthalmol Vis Sci 59:4238-4248
Davidson, Benjamin; Kalitzeos, Angelos; Carroll, Joseph et al. (2018) Automatic Cone Photoreceptor Localisation in Healthy and Stargardt Afflicted Retinas Using Deep Learning. Sci Rep 8:7911
Reid, Christopher A; Nettesheim, Emily R; Connor, Thomas B et al. (2018) Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD. Sci Rep 8:11763

Showing the most recent 10 out of 517 publications