ADMINISTRATIVE CORE Principal Investigator Matthew M. LaVail, Ph.D. is an internationally known senior vision scientist who has used many different types of research approaches, including anatomical, biochemical, classical genetic, molecular genetic and electrophysiological methods, as well as animal model development and neurotrophic factor and gene therapy studies for retinal degenerative diseases. His discoveries of circadian rod outer- segment disk shedding and the pharmaceutical rescue of degenerating photoreceptors have led to the establishment of new fields of vision research. He is highly respected at UCSF and in the vision research community. Dr. LaVail has been funded continuously by the NEI for the past 35 or more years with 6 different co-operative agreements, contracts and long-running research grants, so he is fully aware of both the research needs and regulations involved with NIH grants. Also, he has been an active member of the Core Grant Core Directors'Advisory Committee (see below), serving as the Imaging Core's first Director beginning in 1998. Through his leadership and effort in designing and constructing the Core, the Imaging Core has been the most heavily used of our Cores. Dr. LaVail distinguished himself, as well, in establishing procedures that would assure equitable access to the Core, even with very high usage at several times during the year just prior to several research meetings. One year before the retirement of the former Principal Investigator, Dr. Steven Kramer, Dr. LaVail was approved by the NE I to become the new Principal Investigator of the Core Grant effective July 1, 2002. We will use this process in case a Core Director or PI moves, retires or becomes unable to carry out the duties of the position, in which case the person will be identified by the Advisory Committee (see below), and the name will be submitted to the NEI for approval.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1)
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University of California San Francisco
San Francisco
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Draper, Jolene M; Stephenson, Graham S; LaVail, Jennifer H (2014) In vivo HSV-1 DNA transport studies using murine retinal ganglion cells. Methods Mol Biol 1144:283-92
Wang, Sophia Y; Melles, Ronald; Lin, Shan C (2014) The impact of central corneal thickness on the risk for glaucoma in a large multiethnic population. J Glaucoma 23:606-12
Kyung, Sung-eun E; Botelho, James V; Horton, Jonathan C (2014) Enlargement of the sella turcica in pseudotumor cerebri. J Neurosurg 120:538-42
Qiu, Mary; Wang, Sophia Y; Singh, Kuldev et al. (2014) Racial disparities in uncorrected and undercorrected refractive error in the United States. Invest Ophthalmol Vis Sci 55:6996-7005
Lee, Roland Y; Kasuga, Toshimitsu; Cui, Qi N et al. (2014) Comparison of anterior segment morphology following prophylactic laser peripheral iridotomy in Caucasian and Chinese eyes. Clin Experiment Ophthalmol 42:417-26
Barbosa, D T Q; Mendes, T S; CĂ­ntron-Colon, H R et al. (2014) Age-related macular degeneration and protective effect of HMG Co-A reductase inhibitors (statins): results from the National Health and Nutrition Examination Survey 2005-2008. Eye (Lond) 28:472-80
Li, Yingjie; Wang, Ye Elaine; Huang, Guofu et al. (2014) Prevalence and characteristics of plateau iris configuration among American Caucasian, American Chinese and mainland Chinese subjects. Br J Ophthalmol 98:474-8
Liu, Benjamin S; Tarima, Sergey; Visotcky, Alexis et al. (2014) The reliability of parafoveal cone density measurements. Br J Ophthalmol 98:1126-31
Ray, Kathryn J; Srinivasan, Muthiah; Mascarenhas, Jeena et al. (2014) Early addition of topical corticosteroids in the treatment of bacterial keratitis. JAMA Ophthalmol 132:737-41
Economides, John R; Adams, Daniel L; Horton, Jonathan C (2014) Eye choice for acquisition of targets in alternating strabismus. J Neurosci 34:14578-88

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