The primary objective of this application is to provide NEI-funded vision scientists with state-of-the-art, shared technical support to enhance their individual research efforts. A secondary goal is to foster collaborative research, as a means of attracting scientists who currently do not work on the visual system to the field of eye research. These objectives will be achieved through the activity of four core modules, which will provide the following services: 1. A Morphology &Imaging module will provide technical support and expertise in the morphological analysis of ocular cells and tissues at the light and electron microscopic level. 2. A Visual Function Testing module will provide equipment and technical expertise for the assessment of visual performance in experimental animal model systems. 3. A Molecular Genetics module will provide assistance and expertise in the production of transgenic/knockout/knockin mice, construction of gene constructs, and preparation of DNA clones and probes. 4. A Biostatistics module will assist in the design and implementation of pilot studies, provide statistical and methodological expertise in study design, assure the validity of statistical analyses and reported results, and assist in training residents and clinicians in areas of research methodology. Provision of these support services and resources will greatly enhance the research capabilities of investigators at Washington University and will facilitate collaboration among new and established vision scientists.

Public Health Relevance

The vision research community at Washington Universtity is large and diverse and makes a substantial contribution to the diagnosis and treatment of blinding eye disease. The provision of shared resources and technical support through the Vision Science Core allows investigators to achieve more progress on their NEI-funded projects than would have been possible otherwise.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
3P30EY002687-33S1
Application #
8366628
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
Project Start
1997-04-01
Project End
2015-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
33
Fiscal Year
2012
Total Cost
$424,001
Indirect Cost
Name
Washington University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Anderson, Andrew J; Stainer, Matthew J (2014) A control experiment for studies that show improved visual sensitivity with intraocular pressure lowering in glaucoma. Ophthalmology 121:2028-32
Chen, Ziyan; Huang, Jie; Liu, Ying et al. (2014) FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Development 141:2691-701
Masuda, Tomohiro; Zhang, Xiaodong; Berlinicke, Cindy et al. (2014) The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina. J Neurosci 34:15356-68
Tran, Nicholas M; Chen, Shiming (2014) Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies. Dev Dyn 243:1153-66
Oladipupo, Sunday S; Smith, Craig; Santeford, Andrea et al. (2014) Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A 111:13379-84
Solga, A C; Gianino, S M; Gutmann, D H (2014) NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma. Oncogene 33:289-99
Sakami, Sanae; Kolesnikov, Alexander V; Kefalov, Vladimir J et al. (2014) P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet 23:1723-41
Sene, Abdoulaye; Apte, Rajendra S (2014) Eyeballing cholesterol efflux and macrophage function in disease pathogenesis. Trends Endocrinol Metab 25:107-14
Sundermeier, Thomas R; Vinberg, Frans; Mustafi, Debarshi et al. (2014) R9AP overexpression alters phototransduction kinetics in iCre75 mice. Invest Ophthalmol Vis Sci 55:1339-47
Vinberg, Frans; Kolesnikov, Alexander V; Kefalov, Vladimir J (2014) Ex vivo ERG analysis of photoreceptors using an in vivo ERG system. Vision Res 101:108-17

Showing the most recent 10 out of 556 publications