In 1979, a NEI Core Grant was awarded to the University of Alabama at Birmingham (UAB). Over the next 30 years, the institution's continued commitment to growth resulted in a remarkable expansion in vision research at UAB. Participants in the Core Grant have increased from thirteen in two departments to twenty-nine representing eight departments, and there has been a concomitant increase in extramural funding. Annually, NEI funding to Core Grant participants exceeds $3 million, not including institutional awards. Total extramural funding for vision-related research at UAB has grown from just over $6 million in 1998 to $15 million in 2008. A major research focus of the group is visual neuroscience, with seventeen of the participants actively involved in anatomical, biochemical, physiological, and psychophysical studies of the retina and central visual pathways. Other areas of research include myopia, biochemistry of the lens and cornea, and vitreous biochemistry. This application requests funds to continue to provide services and facilities to UAB Core Grant participants through the Electronics, Machine Shop, Computer and Molecular and Cellular Analysis modules. These modules provide easily accessible technical facilities and the expertise to use them in dedicated spaces designed specifically for each purpose. The Electronics Module is staffed by an Electronics Engineer and includes all of the equipment required to design and build new electronic apparatus, and to provide repair and maintenance services. The Computer Module provides access to high-end computers and peripherals, custom programming capability, and assistance with office and lab computers and software. A computer programmer is available for systems administration, and networking. The Machine Shop is fully equipped with a lathe, milling machine and other machine tools, and is staffed by a Tool and Die Maker who designs and fabricates new mechanical devices and can repair or maintain mechanical equipment. The Molecular and Cellular Analysis Core provides access to major instrumentation for DNA, RNA and protein studies. A PhD level Research Associate provides expertise and training in all of these areas. In addition, equipment and expertise for tissue analyses including routine tissue processing, histological stains, immunohistochemical studies, and in situ hybridization is available. A part time histological technician provides consultation for experimental design, technical expertise, and training of laboratory personnel.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
3P30EY003039-35S1
Application #
8899929
Study Section
Special Emphasis Panel (ZEY1-VSN (08))
Program Officer
Liberman, Ellen S
Project Start
1997-08-01
Project End
2015-08-31
Budget Start
2013-08-01
Budget End
2015-08-31
Support Year
35
Fiscal Year
2014
Total Cost
$257,002
Indirect Cost
$82,171
Name
University of Alabama Birmingham
Department
Physiology
Type
Schools of Optometry/Ophthalmol
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Zanzottera, Emma C; Ach, Thomas; Huisingh, Carrie et al. (2016) VISUALIZING RETINAL PIGMENT EPITHELIUM PHENOTYPES IN THE TRANSITION TO GEOGRAPHIC ATROPHY IN AGE-RELATED MACULAR DEGENERATION. Retina :
Ward, Alexander H; Siegwart Jr, John T; Frost, Michael R et al. (2016) The effect of intravitreal injection of vehicle solutions on form deprivation myopia in tree shrews. Exp Eye Res 145:289-96
Griffis, Joseph C; Elkhetali, Abdurahman S; Burge, Wesley K et al. (2016) Retinotopic patterns of functional connectivity between V1 and large-scale brain networks during resting fixation. Neuroimage :
Litts, Katie M; Ach, Thomas; Hammack, Kristen M et al. (2016) Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology. Invest Ophthalmol Vis Sci 57:2647-56
Lu, Jing; Gu, Boyu; Wang, Xiaolin et al. (2016) Adaptive optics parallel near-confocal scanning ophthalmoscopy. Opt Lett 41:3852-5
Choudhury, Shreyasi; Strang, Christianne E; Alexander, John J et al. (2016) Novel Methodology for Creating Macaque Retinas with Sortable Photoreceptors and Ganglion Cells. Front Neurosci 10:551
Chakraborty, Dibyendu; Conley, Shannon M; Pittler, Steven J et al. (2016) Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration. Invest Ophthalmol Vis Sci 57:787-97
Burge, Wesley K; Griffis, Joseph C; Nenert, Rodolphe et al. (2016) Cortical thickness in human V1 associated with central vision loss. Sci Rep 6:23268
Zanzottera, Emma C; Ach, Thomas; Huisingh, Carrie et al. (2016) VISUALIZING RETINAL PIGMENT EPITHELIUM PHENOTYPES IN THE TRANSITION TO ATROPHY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina :
Liao, Hsi-Wen; Ren, Xiaozhi; Peterson, Beth B et al. (2016) Melanopsin-expressing ganglion cells on macaque and human retinas form two morphologically distinct populations. J Comp Neurol 524:2845-72

Showing the most recent 10 out of 296 publications