Funds are requested for continued funding of our Core Grant for Vision Research (EY03040). Since its inception in 1979, this grant has supported the development of a premier program in vision research at the Doheny Eye Institute (DEI) in association with the Departments of Ophthalmology at the University of Southern California Keck School of Medicine (KSOM) and Children's Hospital (CHLA) at Los Angeles. The growth of DEI to be fourth in the nation in receipt of NEI funds can be attributed in no small part to the support provided by this grant. The proposed Core consists of four service modules: Biostatistics, Histology and Immunopathology, Specialized Microscopy, and a new module, Functional Genomics. It supports the salaries of expert supervisor/technicians and a modest amount of supplies for each module. The Director of each module is a PI on at least 1 NEI R01 grant. The faculty users hold 27 NEI grants (15 R01s, 1 R01 subcontract, 3 U10s, 1 K23, 2 R21s, 3 R03s, 1 R24 subcontract and 1 R43 subcontract). This Core Grant has supported the publication of 800 peer-reviewed papers since its inception. Productivity of the group has been excellent over the past grant period, with 216 peer-reviewed publications, most of which represent collaborative studies. The availably of the Core Grant has supported the recruitment of 13 new research faculty, who now hold 2 R01s, 1 R03, 2 R21s, 1 R01 subcontract, 1 R24 subcontract and 1 R43 subcontract from the NEI, in addition to 2 federal grants from the Department of Energy, 2 federal grants from the National Science foundation, and 3 grants from private foundations. Each of our NEI grants relies heavily on one or more services provided by the Core modules. The expert staff associated with the modules could not be afforded or justified by the demands of any one grant, but are fully justified by the requirements of the combined faculty. A great strength of this program is the support it provides for new faculty and collaborative studies involving other disciplines.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY003040-30
Application #
7860442
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
Project Start
1997-04-01
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
30
Fiscal Year
2010
Total Cost
$684,911
Indirect Cost
Name
Doheny Eye Institute
Department
Type
DUNS #
020738787
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Kim, Esther Lee; Tran, Jeffrey; Töteberg-Harms, Marc et al. (2017) Vision Loss and Recovery after Baerveldt Aqueous Tube Shunt Implantation. J Ophthalmol 2017:4140305
Eandi, Chiara M; Charles Messance, Hugo; Augustin, Sébastien et al. (2016) Subretinal mononuclear phagocytes induce cone segment loss via IL-1?. Elife 5:
Kochounian, Harold; Zhang, Zhaoxia; Spee, Christine et al. (2016) Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9. Mol Vis 22:213-23
Boado, Ruben J; Lu, Jeff Zhiqiang; Hui, Eric Ka-Wai et al. (2016) Insulin Receptor Antibody-?-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts. Mol Pharm 13:1385-92
Deming, Janise D; Van Craenenbroeck, Kathleen; Eom, Yun Sung et al. (2016) Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4. Adv Exp Med Biol 854:663-70
Carelli, Valerio; d'Adamo, Pio; Valentino, Maria Lucia et al. (2016) Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion. Brain 139:e17
Gonzalez Jr, Jose M; Ammar, Michael J; Ko, MinHee K et al. (2016) Optimizing two-photon multiple fluorophore imaging of the human trabecular meshwork. Mol Vis 22:203-12
Ishikawa, Keijiro; Kannan, Ram; Hinton, David R (2016) Molecular mechanisms of subretinal fibrosis in age-related macular degeneration. Exp Eye Res 142:19-25
Gonzalez, Jose M; Ko, Minhee K; Pouw, Andrew et al. (2016) Tissue-based multiphoton analysis of actomyosin and structural responses in human trabecular meshwork. Sci Rep 6:21315
Sreekumar, Parameswaran G; Ishikawa, Keijiro; Spee, Chris et al. (2016) The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci 57:1238-53

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