Funds are requested for continued funding of our Core Grant for Vision Research (EY003040). Since its inception in 1979, this grant has supported the development of a premier program in vision research at the Doheny Eye Institute (DEI) in association with the Department of Ophthalmology at the Keck School of Medicine (KSOM) of the University of Southern California. The growth of DEI as a leader in the field of vision research and as a recipient of NEI funding can be attributed in no small part to the support provided by this grant. The proposed Core consists of three service modules: Biostatistics, Specialized Microscopy, and Translational Molecular Pathology. It supports the salaries of expert supervisor/technicians and a modest amount of supplies for each module. The Director of each module is well-experienced in his field, has overseen his module successfully and productively for a number of years, and is a PI or Investigator on at least 1 NEI R01 or U10 grant. The faculty users hold 24 NEI grants (18 R01s, 3 UIOs, 2 K08s, and 1 R56) and 5 sub awards on NEI grants. This Core Grant has supported the publication of 1,292 peer-reviewed papers since its inception. Productivity of the group has been excellent over the past grant period, with 292 peer-reviewed publications, most of which represent collaborative studies. The availability of the Core Grant has supported the recruitment of new research faculty, who now hold 2 ROIs and 2 K08s from the NEI. Each of our NEI grants relies heavily on one or more services provided by the Core modules. The expert staff associated with the modules could not be afforded or justified by the demands of any one grant, but are fully justified by the requirements of the combined faculty. A great strength of this program is the support it provides for new faculty and collaborative studies involving other disciplines.

Public Health Relevance

The Core Grant supports the research of DEI and USC Ophthalmology vision scientists in the study and treatment of a broad field of diseases of the eye. The facilities, equipment and professional expertise provided by the Core Grant substantially increase the success of these studies in their furtherance of good vision health.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1-VSN (10))
Program Officer
Liberman, Ellen S
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Doheny Eye Institute
Los Angeles
United States
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Kannan, Ram; Sreekumar, Parameswaran G; Hinton, David R (2016) Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration. Biochim Biophys Acta 1860:258-68
Deming, Janise D; Van Craenenbroeck, Kathleen; Eom, Yun Sung et al. (2016) Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4. Adv Exp Med Biol 854:663-70
Boado, Ruben J; Lu, Jeff Zhiqiang; Hui, Eric Ka-Wai et al. (2016) Insulin Receptor Antibody-α-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts. Mol Pharm 13:1385-92
Huang, Alex S; Saraswathy, Sindhu; Dastiridou, Anna et al. (2016) Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes. Transl Vis Sci Technol 5:5
Saraswathy, Sindhu; Tan, James C H; Yu, Fei et al. (2016) Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging. PLoS One 11:e0147176
Kochounian, Harold; Zhang, Zhaoxia; Spee, Christine et al. (2016) Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9. Mol Vis 22:213-23
Carelli, Valerio; d'Adamo, Pio; Valentino, Maria Lucia et al. (2016) Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion. Brain 139:e17
Sreekumar, Parameswaran G; Ishikawa, Keijiro; Spee, Chris et al. (2016) The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci 57:1238-53
La Morgia, Chiara; Ross-Cisneros, Fred N; Koronyo, Yosef et al. (2016) Melanopsin retinal ganglion cell loss in Alzheimer disease. Ann Neurol 79:90-109
Giordano, Carla; Carelli, Valerio (2016) Reply: Mitochondrial DNA copy number differentiates the Leber's hereditary optic neuropathy affected individuals from the unaffected mutation carriers. Brain 139:e2

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