Funds are requested for continued funding of our Core Grant for Vision Research (EY003040). Since its inception in 1979, this grant has supported the development of a premier program in vision research at the Doheny Eye Institute (DEI) in association with the Department of Ophthalmology at the Keck School of Medicine (KSOM) of the University of Southern California. The growth of DEI as a leader in the field of vision research and as a recipient of NEI funding can be attributed in no small part to the support provided by this grant. The proposed Core consists of three service modules: Biostatistics, Specialized Microscopy, and Translational Molecular Pathology. It supports the salaries of expert supervisor/technicians and a modest amount of supplies for each module. The Director of each module is well-experienced in his field, has overseen his module successfully and productively for a number of years, and is a PI or Investigator on at least 1 NEI R01 or U10 grant. The faculty users hold 24 NEI grants (18 R01s, 3 UIOs, 2 K08s, and 1 R56) and 5 sub awards on NEI grants. This Core Grant has supported the publication of 1,292 peer-reviewed papers since its inception. Productivity of the group has been excellent over the past grant period, with 292 peer-reviewed publications, most of which represent collaborative studies. The availability of the Core Grant has supported the recruitment of new research faculty, who now hold 2 ROIs and 2 K08s from the NEI. Each of our NEI grants relies heavily on one or more services provided by the Core modules. The expert staff associated with the modules could not be afforded or justified by the demands of any one grant, but are fully justified by the requirements of the combined faculty. A great strength of this program is the support it provides for new faculty and collaborative studies involving other disciplines.

Public Health Relevance

The Core Grant supports the research of DEI and USC Ophthalmology vision scientists in the study and treatment of a broad field of diseases of the eye. The facilities, equipment and professional expertise provided by the Core Grant substantially increase the success of these studies in their furtherance of good vision health.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY003040-31A1
Application #
8339125
Study Section
Special Emphasis Panel (ZEY1-VSN (10))
Program Officer
Liberman, Ellen S
Project Start
1997-04-01
Project End
2014-09-30
Budget Start
2012-09-30
Budget End
2014-09-30
Support Year
31
Fiscal Year
2012
Total Cost
$616,620
Indirect Cost
$187,930
Name
Doheny Eye Institute
Department
Type
DUNS #
020738787
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Kim, Hwa Sun; Huang, Shun-Ping; Lee, Eun-Jin et al. (2018) Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice. Adv Exp Med Biol 1074:281-287
Gonzalez Jr, Jose M; Ko, Minhee K; Masedunskas, Andrius et al. (2017) Toward in vivo two-photon analysis of mouse aqueous outflow structure and function. Exp Eye Res 158:161-170
Carelli, Valerio; La Morgia, Chiara; Ross-Cisneros, Fred N et al. (2017) Optic neuropathies: the tip of the neurodegeneration iceberg. Hum Mol Genet 26:R139-R150
Kim, Esther Lee; Tran, Jeffrey; Töteberg-Harms, Marc et al. (2017) Vision Loss and Recovery after Baerveldt Aqueous Tube Shunt Implantation. J Ophthalmol 2017:4140305
Boado, Ruben J; Lu, Jeff Zhiqiang; Hui, Eric Ka-Wai et al. (2016) Insulin Receptor Antibody-?-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts. Mol Pharm 13:1385-92
Kochounian, Harold; Zhang, Zhaoxia; Spee, Christine et al. (2016) Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9. Mol Vis 22:213-23
Deming, Janise D; Van Craenenbroeck, Kathleen; Eom, Yun Sung et al. (2016) Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4. Adv Exp Med Biol 854:663-70
Choudhury, Farzana; Varma, Rohit; Klein, Ronald et al. (2016) Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study. JAMA Ophthalmol 134:683-90
Gonzalez Jr, Jose M; Ammar, Michael J; Ko, MinHee K et al. (2016) Optimizing two-photon multiple fluorophore imaging of the human trabecular meshwork. Mol Vis 22:203-12
Ishikawa, Keijiro; Kannan, Ram; Hinton, David R (2016) Molecular mechanisms of subretinal fibrosis in age-related macular degeneration. Exp Eye Res 142:19-25

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