The primary purpose of the Translational Research module is to promote and facilitate inter-disciplinary collaborations among vision scientists, clinician scientists, and clinicians who do not have the means or expertise to conduct innovative, translational, patient-based clinical research. The UC Berkeley Clinical Research Center (CRC) housed in the School of Optometry was established in 2004. The CRC was created with the aim of supporting vision researchers, academic institutional partners, and private sector companies to explore new models and strategies for the prevention, diagnosis, and treatment of ocular anomalies. To accomplish this, the CRC established an infrastructure with a professional staff to conduct basic-science and translational research as well as patient-based clinical studies and trials. To date, the CRCs collaborations with basic science researchers have been successful but on a small scale, due primarily to funding constraints. Examples of these research activities include collaborations with principal investigators (PIs) within UC Berkeley campus on various vision-related research studies, including accommodation (Co-PI: Cliff Schor/Optometry) innovative non-thermal and non-chemical sterilization technique of contact lenses (Co-PI: Boris Rubinsky/Bioengineering);myopia (Co-PI: Chris Wildoset/Optometry);genetic influence on contact lens-induced adverse events (Co-PI: Lisa Barcellos/Public Health);environmental stress on tear film biophysical and biochemical properties (Co-PI: Randy Maddalena/LBNL);a novel OCT technique to examine retinal layers (Co-PI: Brandon Lujan/Optometry);Amblyopia (Co-PI: Dennis Levi/Optometry), and rheology of tear film (Co-Pl: Tatyana Svitova and Clayton Radke/Chemical Engineering).^"* These projects are in progress with manuscripts in preparation. A Core Translational Research module would enable expansion of the CRC to support significantly larger scale (e.g., longitudinal clinical trials) multi-disciplinary, interdepartmental collaborations. This support would include clinical research study design, recruitment of research subjects and compliance with institutional review boards (IRB) overseeing human subject research, conduct of clinical studies and trials, statistical analysis, and collaborative reporting of study results. The resources ofthe CRC, under the direction ofthe module co-directors, would be available to basic science researchers in the greater vision science community (with priority given to CORE grant P.l.s), including professional and support staff.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY003176-31
Application #
8685382
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
31
Fiscal Year
2013
Total Cost
$216,878
Indirect Cost
$78,298
Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
McNamara, Nancy A; Ge, Shaokui; Lee, Salena M et al. (2016) Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome. Invest Ophthalmol Vis Sci 57:5237-5243
Rosa, Juliana M; Morrie, Ryan D; Baertsch, Hans C et al. (2016) Contributions of Rod and Cone Pathways to Retinal Direction Selectivity Through Development. J Neurosci 36:9683-95
Denison, Rachel N; Sheynin, Jacob; Silver, Michael A (2016) Perceptual suppression of predicted natural images. J Vis 16:6
Vlasits, Anna L; Morrie, Ryan D; Tran-Van-Minh, Alexandra et al. (2016) A Role for Synaptic Input Distribution in a Dendritic Computation of Motion Direction in the Retina. Neuron 89:1317-30
Metlapally, Sangeetha; Tong, Jianliang L; Tahir, Humza J et al. (2016) Potential role for microfluctuations as a temporal directional cue to accommodation. J Vis 16:19
Arroyo, David A; Kirkby, Lowry A; Feller, Marla B (2016) Retinal Waves Modulate an Intraretinal Circuit of Intrinsically Photosensitive Retinal Ganglion Cells. J Neurosci 36:6892-905
Tochitsky, Ivan; Helft, Zachary; Meseguer, Victor et al. (2016) How Azobenzene Photoswitches Restore Visual Responses to the Blind Retina. Neuron 92:100-113
Firl, Alana; Ke, Jiang-Bin; Zhang, Lei et al. (2015) Elucidating the role of AII amacrine cells in glutamatergic retinal waves. J Neurosci 35:1675-86
Tochitsky, Ivan; Kramer, Richard H (2015) Optopharmacological tools for restoring visual function in degenerative retinal diseases. Curr Opin Neurobiol 34:74-8
Kramer, Richard H; Davenport, Christopher M (2015) Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter. PLoS Biol 13:e1002322

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