The vision science community at UC Berkeley has a long and distinguished history, having contributed many seminal discoveries in the fields of visual system development, physiology, psychophysics, and pathology. UC Berkeley vision scientists come from many academic disciplines, increasing our understanding of vision at many different levels. Our group consists of 20 CORE investigators, ranging in expertise and interest from molecular mechanisms of synaptic function to human visual perception. We request continued support for our CORE grant to ensure further success in vision research through shared resources and services. We seek funding for four modules which will support current faculty and attract new faculty to investigate the visual system. The modules are:: (1) Gene Delivery (Xiaohua Gong &John Flannery, co-directors), designed to provide molecular biology expertise and support in the use of viral vectors for delivering genes into tissues of the visual system and for creating transgenic animal models of ocular disease. (2) Microscopic Imaging (Maria Feller, director), which will apply and develop advanced imaging methods for vision research - facilitating the use of shared-access microscopes on the Berkeley Campus and customizing microscopes in the labs of participating investigators. (3) Software Development (Marty Banks, director), which will provide custom software solutions for shared use by visual system investigators using psychophysical and physiological methods. (4) Translational Research, to promote translation of scientific knowledge into clinical applications by supporting design, data collection, and data analysis of experiments involving human subjects. To build on our current strengths, the UC Berkeley Depts. of Molecular &Cell Biology, Psychology, Optometry, and the Helen Wills Neuroscience Institute have all targeted vision research as a priority area for new faculty hiring. Further demonstrating their commitment, these administrative groups and the University Administration have committed to collectively provide resources equivalent to $800,000 over the next 5 years to support the Vision Science CORE.

Public Health Relevance

The research activities supported by the Vision Science CORE grant are critical for advancing our understanding of the basic mechanisms of vision, and remain essential for our long-term goal of understanding, treating, and ultimately curing visual disorders.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30EY003176-32
Application #
8694035
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
Project End
Budget Start
Budget End
Support Year
32
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Wang, Tzu-Ming; Holzhausen, Lars C; Kramer, Richard H (2014) Imaging an optogenetic pH sensor reveals that protons mediate lateral inhibition in the retina. Nat Neurosci 17:262-8
Robertson, Danielle M; Alexander, Larry J; Bonanno, Joseph A et al. (2014) Cornea and ocular surface disease: application of cutting-edge optometric research. Optom Vis Sci 91:S3-16
Tochitsky, Ivan; Polosukhina, Aleksandra; Degtyar, Vadim E et al. (2014) Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells. Neuron 81:800-13
Vlasits, Anna L; Bos, RĂ©mi; Morrie, Ryan D et al. (2014) Visual stimulation switches the polarity of excitatory input to starburst amacrine cells. Neuron 83:1172-84
Piazza, Elise A; Silver, Michael A (2014) Persistent hemispheric differences in the perceptual selection of spatial frequencies. J Cogn Neurosci 26:2021-7
Denison, Rachel N; Vu, An T; Yacoub, Essa et al. (2014) Functional mapping of the magnocellular and parvocellular subdivisions of human LGN. Neuroimage 102 Pt 2:358-69
Lin, Wan-Chen; Davenport, Christopher M; Mourot, Alexandre et al. (2014) Engineering a light-regulated GABAA receptor for optical control of neural inhibition. ACS Chem Biol 9:1414-9
Piazza, Elise A; Sweeny, Timothy D; Wessel, David et al. (2013) Humans use summary statistics to perceive auditory sequences. Psychol Sci 24:1389-97
Chung, Susana T L (2013) The Glenn A. Fry Award Lecture 2012: Plasticity of the visual system following central vision loss. Optom Vis Sci 90:520-9
Bressler, David W; Fortenbaugh, Francesca C; Robertson, Lynn C et al. (2013) Visual spatial attention enhances the amplitude of positive and negative fMRI responses to visual stimulation in an eccentricity-dependent manner. Vision Res 85:104-12

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