Continued support is requested forth NEI Core Grant for Vision Research at Emory University and neighboring Atlanta institutions. This Core Center Grant renewal application includes three Modules: (1) Structural Biology and Imaging, (2) Functional Genomics and Proteomics, and (3) Bioinformatics and Biostatistics. The past core grant supported collaborative vision research and service among 42 faculty (including 36 separate awards by 31 NEI funded principal investigators),16 postdoctoral fellows, 6 predoctoral fellows and generated 500+ peer-reviewed publications in the past 5 years. The Structural Biology and Imaging Module adds ultrasonography in this renewal to existing support for immunohistochemistry, confocal microscopy, fluorescence image analysis, and light and electron microscopy services. The Functional Genomics and Proteomics module adds new capabilities for visual phenotyping of rodents, including SD-OCT, scanning laser ophthalmoscopy, partial coherence interferometry, high precision micrometry, photorefraction, gonioscopy, rebound tonometry, ERG, and OKT, to pre-existing services for oligonucleotide synthesis, HPLC analyses, mass spectrometry, PCR, laser capture microdissection, gene and protein sequencing, and microarray analysis. The Bioinformatics and Biostatistics Module provides biostatistics, bioinformatics, data management, electronic notebooks, data backups, and advanced computational analyses. The Core is administered by the Program Director and one-two Module Directors for each of the Modules;a Core Grant Advisory Committee will aid the module directors to insure full and equitable use of the facilities and to advise on creation of new resources based on need or eliminate components that are underutilized. The Core Modules have and will continue to increase research productivity by providing common centralized services to stimulate and facilitate collaborative studies among faculty and to attract other academic disciplines to vision research.

Public Health Relevance

This Core facility serves as a centralized vision research resource in Atlanta where faculty from Emory Univ., Yerkes Primate Center, the CDC, Georgia Tech, Georgia State University, Morehouse School of Medicine, and The Atlanta Veterans Administration Medical Center can undertake joint studies in vision research. The Core facilities also serve a role in the research projects of pre- and postdoctoral fellows supported by our NEI Training Grant (T32 EY7092-24), recently renewed for five years (2009-2014).

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY006360-26
Application #
8152399
Study Section
Special Emphasis Panel (ZEY1-VSN (05))
Program Officer
Liberman, Ellen S
Project Start
1997-04-01
Project End
2016-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
26
Fiscal Year
2011
Total Cost
$620,000
Indirect Cost
Name
Emory University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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Dattilo, Michael; Biousse, Valérie; Newman, Nancy J (2017) Update on the Management of Central Retinal Artery Occlusion. Neurol Clin 35:83-100
Giangiacomo, Annette; Beck, Allen (2017) Pediatric glaucoma: review of recent literature. Curr Opin Ophthalmol 28:199-203
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Alston, Christine I; Dix, Richard D (2017) Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3. PLoS One 12:e0171812
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Dattilo, Michael; Vasseneix, Caroline; Bruce, Beau B et al. (2017) Correlation between Stereopsis and Reverse Stereopsis. Ophthalmology 124:411-413
Alston, Christine I; Dix, Richard D (2017) Reduced frequency of murine cytomegalovirus retinitis in C57BL/6 mice correlates with low levels of suppressor of cytokine signaling (SOCS)1 and SOCS3 expression within the eye during corticosteroid-induced immunosuppression. Cytokine 97:38-41
Tran, Jeffrey; Craven, Caroline; Wabner, Kathy et al. (2017) A Pharmacodynamic Analysis of Choroidal Neovascularization in a Porcine Model Using Three Targeted Drugs. Invest Ophthalmol Vis Sci 58:3732-3740
Biousse, Valérie (2017) Neuro-Ophthalmology and Stroke. J Neuroophthalmol 37:223-224

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