Continued support is requested forth NEI Core Grant for Vision Research at Emory University and neighboring Atlanta institutions. This Core Center Grant renewal application includes three Modules: (1) Structural Biology and Imaging, (2) Functional Genomics and Proteomics, and (3) Bioinformatics and Biostatistics. The past core grant supported collaborative vision research and service among 42 faculty (including 36 separate awards by 31 NEI funded principal investigators),16 postdoctoral fellows, 6 predoctoral fellows and generated 500+ peer-reviewed publications in the past 5 years. The Structural Biology and Imaging Module adds ultrasonography in this renewal to existing support for immunohistochemistry, confocal microscopy, fluorescence image analysis, and light and electron microscopy services. The Functional Genomics and Proteomics module adds new capabilities for visual phenotyping of rodents, including SD-OCT, scanning laser ophthalmoscopy, partial coherence interferometry, high precision micrometry, photorefraction, gonioscopy, rebound tonometry, ERG, and OKT, to pre-existing services for oligonucleotide synthesis, HPLC analyses, mass spectrometry, PCR, laser capture microdissection, gene and protein sequencing, and microarray analysis. The Bioinformatics and Biostatistics Module provides biostatistics, bioinformatics, data management, electronic notebooks, data backups, and advanced computational analyses. The Core is administered by the Program Director and one-two Module Directors for each of the Modules;a Core Grant Advisory Committee will aid the module directors to insure full and equitable use of the facilities and to advise on creation of new resources based on need or eliminate components that are underutilized. The Core Modules have and will continue to increase research productivity by providing common centralized services to stimulate and facilitate collaborative studies among faculty and to attract other academic disciplines to vision research.

Public Health Relevance

This Core facility serves as a centralized vision research resource in Atlanta where faculty from Emory Univ., Yerkes Primate Center, the CDC, Georgia Tech, Georgia State University, Morehouse School of Medicine, and The Atlanta Veterans Administration Medical Center can undertake joint studies in vision research. The Core facilities also serve a role in the research projects of pre- and postdoctoral fellows supported by our NEI Training Grant (T32 EY7092-24), recently renewed for five years (2009-2014).

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1-VSN (05))
Program Officer
Liberman, Ellen S
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Emory University
Schools of Medicine
United States
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Bidot, Samuel; Bruce, Beau B; Saindane, Amit M et al. (2015) Asymmetric papilledema in idiopathic intracranial hypertension. J Neuroophthalmol 35:31-6
Ziesel, Alison; Bernstein, Steven; Wong, Paul W (2014) Generation of a foveomacular transcriptome. Mol Vis 20:947-54
Kim, Yoo C; Grossniklaus, Hans E; Edelhauser, Henry F et al. (2014) Intrastromal delivery of bevacizumab using microneedles to treat corneal neovascularization. Invest Ophthalmol Vis Sci 55:7376-86
Bialer, Omer Y; Saindane, Amit M; Newman, Nancy J (2014) Orbital MRI appearance after remote retrobulbar alcohol injection. Ophthal Plast Reconstr Surg 30:e102-3
McMahon, Douglas G; Iuvone, P Michael; Tosini, Gianluca (2014) Circadian organization of the mammalian retina: from gene regulation to physiology and diseases. Prog Retin Eye Res 39:58-76
Hwang, Cindy S; Yeh, Steven; Bergstrom, Chris S (2014) Diagnostic vitrectomy for primary intraocular lymphoma: when, why, how? Int Ophthalmol Clin 54:155-71
Bialer, Omer Y; Rueda, Mario Perez; Bruce, Beau B et al. (2014) Meningoceles in idiopathic intracranial hypertension. AJR Am J Roentgenol 202:608-13
Chakraborty, Ranjay; Lacy, Kip D; Tan, Christopher C et al. (2014) Refractive index measurement of the mouse crystalline lens using optical coherence tomography. Exp Eye Res 125:62-70
Kim, Joon-Bom; Jeroudi, Abdallah; Angeles-Han, Sheila T et al. (2014) Adalimumab for pediatric sympathetic ophthalmia. JAMA Ophthalmol 132:1022-4
Grossniklaus, Hans E (2014) Retinoblastoma. Fifty years of progress. The LXXI Edward Jackson Memorial Lecture. Am J Ophthalmol 158:875-91

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