Continued support is sought for the Core Center for Vision Research at the University of Michigan. Support for five modules is requested: 1) an Electronics and Computer Module for designing and constructing electronic equipment and providing assistance with research computers and their interfaces with laboratory instruments, staffed by an electronics engineer;2) a Functional Assessment Module for the imaging of ocular structures and the evaluation of ocular function in living animals, staffed by a technician;3) an Instrument Shop Module, for designing and constructing custom mechanical instrumentation and modifying or repairing existing instrumentation, staffed by an instrument maker;4) a Molecular Biology Module for providing access to instrumentation and services necessary for molecular biology as well as assistance with the analysis of microarray and bioinformatics data, staffed by a technician and a statistical geneticist;and 5) a Morphology and Imaging Module for providing access to state-of-the-art equipment and expert personnel for the processing of ocular tissues, microscopy (light, wide-field fluorescence, and confocal), and image analysis, staffed by a technician.
The specific aims of the Core Center for Vision Research at the University of Michigan are to enhance the research environment for vision scientists, facilitate collaborative studies of the visual system and its diseases, and expand vision research on this campus to bring the skills and perspectives of non-vision scientists to bear on research issues of the visual system. The 24 participating investigators currently hold 13 NEI R01 grants as well as 6 other NEI research grants. The research interests of these investigators are diverse and include electrophysiology, neurobiology, biochemistry, molecular biology, molecular genetics, developmental biology, biostatistics, immunology, and clinical ophthalmology. The Core Center is housed within the W.K. Kellogg Eye center, a 300,000 sq. ft. building complex containing space dedicated to each of the modules, plus state-of-the-art facilities for basic and clinical research.

Public Health Relevance

The purpose of the Core Center for Vision Research at the University of Michigan is to enhance the research environment for vision scientists, facilitate collaborative studies of the visual system and its diseases, and expand vision research at the University of Michigan to bring the skills and perspectives of non-vision scientists to bear upon research issues of the visual system.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY007003-27
Application #
8511636
Study Section
Special Emphasis Panel (ZEY1-VSN (10))
Program Officer
Liberman, Ellen S
Project Start
1997-05-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
27
Fiscal Year
2013
Total Cost
$570,993
Indirect Cost
$203,795
Name
University of Michigan Ann Arbor
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Lenkowski, Jenny R; Raymond, Pamela A (2014) Müller glia: Stem cells for generation and regeneration of retinal neurons in teleost fish. Prog Retin Eye Res 40:94-123
Gage, Philip J; Kuang, Chen; Zacharias, Amanda L (2014) The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea. Dev Dyn 243:1391-400
Newman-Casey, Paula Anne; Talwar, Nidhi; Nan, Bin et al. (2014) The potential association between postmenopausal hormone use and primary open-angle glaucoma. JAMA Ophthalmol 132:298-303
Zhao, Xiwu; Stafford, Ben K; Godin, Ashley L et al. (2014) Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells. J Physiol 592:1619-36
Muthusamy, Arivalagan; Lin, Cheng-Mao; Shanmugam, Sumathi et al. (2014) Ischemia-reperfusion injury induces occludin phosphorylation/ubiquitination and retinal vascular permeability in a VEGFR-2-dependent manner. J Cereb Blood Flow Metab 34:522-31
Stafford, Benjamin K; Park, Silvia J H; Wong, Kwoon Y et al. (2014) Developmental changes in NMDA receptor subunit composition at ON and OFF bipolar cell synapses onto direction-selective retinal ganglion cells. J Neurosci 34:1942-8
Gramage, E; Li, J; Hitchcock, P (2014) The expression and function of midkine in the vertebrate retina. Br J Pharmacol 171:913-23
Grzegorski, Steven J; Chiari, Estelle F; Robbins, Amy et al. (2014) Natural variability of Kozak sequences correlates with function in a zebrafish model. PLoS One 9:e108475
Stafford, Benjamin K; Manookin, Michael B; Singer, Joshua H et al. (2014) NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells. J Physiol 592:4877-89
Garnai, Sarah J; Huyghe, Jeroen R; Reed, David M et al. (2014) Congenital cataracts: de novo gene conversion event in CRYBB2. Mol Vis 20:1579-93

Showing the most recent 10 out of 78 publications