This P30 proposal requests continued funding to support the operation of five resource modules within the Ophthalmology and Visual Sciences Research Center (OVSRC) at the Eye and Ear Institute of the University of Pittsburgh. The OVSRC provides a home base for the basic and clinical vision research of 22 vision scientists in four departments of the University of Pittsburgh and two departments of Carnegie Mellon University, whose work is advancing the knowledge base on corneal cell biology, glaucoma (imaging, trabecular meshwork stem cell biology and stem cell based therapeutics, and ocular biomechanics), retina (development, stem cell biology and stem cell based therapeutics), visual neuroscience, ocular infectious disease, ocular immunology, and ocular tumors. Ten vision scientists hold 13 qualifying NEI-funded R01 grants (Table 1), 2 vision scientists hold R01 grants that are funded through other NIH institutes despite being highly vision related projects, 2 vision scientists hold R00 grants from the NEI, and one vision scientist holds a KOS award from the NEI. The remaining participants in our Center Core Grant either have applied (5 R01 grants currently pending, many representing first grant applications) or are generating pilot data for planned NEI grants. The Core Grant for Vision Research continues to provide resources, services, and technology that are critical for the vision research efforts at the University of Pittsburgh and Carnegie Mellon University. The Core Grant enhances the overall vision research environment in Pittsburgh by: 1) providing core resources that are critical to the success of vision scientists;2) enhancing collaboration among vision scientists in the Pittsburgh area, and 3) aiding in the recruitment of new vision scientists to Pittsburgh. For the past 24 years, the CORE grant has continued to enhance vision research in the Pittsburgh area by providing cutting edge technology, and incorporate the new knowledge, skills into research projects, and facilitating collaboration among scientists and physician scientists.

Public Health Relevance

The CORE Grant for Vision Research, now in its 24th year supports the efforts of a diverse group of vision scientists in the Pittsburgh area. The grant provides critical ancillary support to NEI-funded investigators, and also supports pilot studies fo new NEI applications. The services and equipment provided by this grant allow our vision scientists to utilize diverse scientific approaches into their vision research projects.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Liberman, Ellen S
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Fiscal Year
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Indirect Cost
University of Pittsburgh
Schools of Medicine
United States
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Bayer, Avraham; Delorme-Axford, Elizabeth; Sleigher, Christie et al. (2015) Human trophoblasts confer resistance to viruses implicated in perinatal infection. Am J Obstet Gynecol 212:71.e1-8
Ksander, Bruce R; Kolovou, Paraskevi E; Wilson, Brian J et al. (2014) ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature 511:353-7
Wu, Jian; Rnjak-Kovacina, Jelena; Du, Yiqin et al. (2014) Corneal stromal bioequivalents secreted on patterned silk substrates. Biomaterials 35:3744-55
Nau, Amy C; Drexler, Scott; Dhaliwal, Deepinder K et al. (2014) Contact lens fitting and long-term management for the Boston keratoprosthesis. Eye Contact Lens 40:185-9
Berdyyeva, Tamara K; Olson, Carl R (2014) Intracortical microstimulation of supplementary eye field impairs ability of monkeys to make serially ordered saccades. J Neurophysiol 111:1529-40
Wu, Jian; Du, Yiqin; Mann, Mary M et al. (2014) Corneal stromal stem cells versus corneal fibroblasts in generating structurally appropriate corneal stromal tissue. Exp Eye Res 120:71-81
Yun, Hongmin; Rowe, Alexander M; Lathrop, Kira L et al. (2014) Reversible nerve damage and corneal pathology in murine herpes simplex stromal keratitis. J Virol 88:7870-80
Swamynathan, Sudha; Swamynathan, Shivalingappa K (2014) SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activator. Invest Ophthalmol Vis Sci 55:6251-61
Bussel, Igor I; Wollstein, Gadi; Schuman, Joel S (2014) OCT for glaucoma diagnosis, screening and detection of glaucoma progression. Br J Ophthalmol 98 Suppl 2:ii15-9
Guedon, J-M G; Zhang, M; Glorioso, J C et al. (2014) Relief of pain induced by varicella-zoster virus in a rat model of post-herpetic neuralgia using a herpes simplex virus vector expressing enkephalin. Gene Ther 21:694-702

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