The Vanderbilt Vision Research Center (VVRC) spanning the College of Arts &Science, Peabody College of Education, School of Engineering and School of Medicine requests continued support for five modules. (1) The Animal Care Module provides specialized enrichment, surgical support and veterinary care of nonhuman primates and other large animals and murine electroretinogram phenotyping. (2) The Computer Module provides hardware installation and maintenance, software development for visual displays and real-time data acquisition and analysis, webpage maintenance and production of illustrations for journals, posters and web pages. (3) The Image Processing Module aids acquisition and analysis of functional brain imaging, optical imaging, confocal and standard microscopy and other imaging data. (4) The Gene &Protein Analysis Module provides timely and economical access to gene microarray, protein mass spectrometry and histopathology services. (5) The Shop Module repairs, designs and fabricates specialized optical, mechanical and electronic instruments. Administrative support is included to ensure continued smooth and stable operation of the VVRC research and training missions. Modules are directed by investigators with NEI funding, have talented and experienced staff and provide services that are otherwise not available or would be prohibitively expensive or slow. During the last grant period, each module was used moderately or extensively by more than three investigators. VVRC investigators produced several hundred publications that made fundamental contributions to basic and clinical visual science. This Core grant has increased collaborations between basic and clinical vision researchers across the Vanderbilt campus and with other institutions. The Core grant has improved our ability to recruit world-class vision researchers resulting in extensive NEI-sponsored research at Vanderbilt. The high level of performance of VVRC investigators, which depends on renewed Core grant support, synergizes with campus-wide initiatives in biomedical research and training at Vanderbilt.

Public Health Relevance

The research facilitated by this Core grant seeks to improve our understanding of the eye and visual system in normal and diseased states. This knowledge will be used to improve the diagnosis and treatment of visual impairments.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY008126-25
Application #
8462617
Study Section
Special Emphasis Panel (ZEY1-VSN (08))
Program Officer
Liberman, Ellen S
Project Start
1997-04-01
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
25
Fiscal Year
2013
Total Cost
$779,997
Indirect Cost
$279,999
Name
Vanderbilt University Medical Center
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Nelson, Matthew J; Murthy, Aditya; Schall, Jeffrey D (2016) Neural control of visual search by frontal eye field: chronometry of neural events and race model processes. J Neurophysiol 115:1954-69
Xu, Lili; Ruan, Guoxiang; Dai, Heng et al. (2016) Mammalian retinal Müller cells have circadian clock function. Mol Vis 22:275-83
Bond, Wesley S; Hines-Beard, Jessica; GoldenMerry, Y Paul L et al. (2016) Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma. Mol Ther 24:230-9
Amato, Katherine R; Wang, Shan; Tan, Li et al. (2016) EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res 76:305-18
Van Gulick, Ana E; McGugin, Rankin W; Gauthier, Isabel (2016) Measuring nonvisual knowledge about object categories: The Semantic Vanderbilt Expertise Test. Behav Res Methods 48:1178-96
Novaleski, Carolyn K; Mizuta, Masanobu; Rousseau, Bernard (2016) Evaluation of Dying Vocal Fold Epithelial Cells by Ultrastructural Features and TUNEL Method. Cells Tissues Organs 202:355-368
Choh, Vivian; Gurdita, Akshay; Tan, Bingyao et al. (2016) Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram Responses. Invest Ophthalmol Vis Sci 57:2140-51
Echevarria, Franklin D; Rickman, Abigayle E; Sappington, Rebecca M (2016) Interleukin-6: A Constitutive Modulator of Glycoprotein 130, Neuroinflammatory and Cell Survival Signaling in Retina. J Clin Cell Immunol 7:
Cooper, Melissa L; Crish, Samuel D; Inman, Denise M et al. (2016) Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma. Exp Eye Res 150:22-33
Tamber-Rosenau, Benjamin J; Marois, René (2016) Central attention is serial, but midlevel and peripheral attention are parallel-A hypothesis. Atten Percept Psychophys 78:1874-88

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