Abstract

- PROTEOMICS AND MASS SPECTROMETRY CORE This National Eye Instituted-funded Proteomics and Mass Spectrometry Core has the long-term objective of using the very latest technologies in the field of proteomics to discover the causes of eye disease, including cataract, glaucoma, age-related macular degeneration, and devise better treatments. Mass spectrometric analysis of proteins will be performed with the specific aims of measuring changes in the abundance of proteins, how proteins fold and interact with one another, and how they become modified in both health and disease. The methods employed will include hydrogen-deuterium exchange to measure solvent accessibility in proteins, chemical cross-linking to define where proteins interact, tandem mass tagging to detect proteins undergoing changes in abundance, and phosphopeptide analysis to discover mechanisms controlling cellular processes. The proposed studies will take advantage of a newly installed state-of-the-art high-resolution mass spectrometer. The results will complement data generated by the other modules supported by this P30 grant to increase the productivity of vision researchers at OHSU and devise better treatments for eye disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY010572-22
Application #
9129701
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
22
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Hegarty, Deborah M; David, Larry L; Aicher, Sue A (2018) Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception. Invest Ophthalmol Vis Sci 59:5217-5224
Pennesi, Mark E; Birch, David G; Jayasundera, K Thiran et al. (2018) Prospective Evaluation of Patients With X-Linked Retinoschisis During 18 Months. Invest Ophthalmol Vis Sci 59:5941-5956
Patel, Rachel; Wang, Jie; Campbell, J Peter et al. (2018) Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography. Invest Ophthalmol Vis Sci 59:4285-4291
Ting, Daniel Shu Wei; Pasquale, Louis R; Peng, Lily et al. (2018) Artificial intelligence and deep learning in ophthalmology. Br J Ophthalmol :
Al-Qahtani, Abdullah A; Ba-Ali, Shakoor; Alabduljalil, Talal et al. (2018) SCLERAL PITS IN CHOROIDEREMIA: Implications for Retinal Gene Therapy. Retina 38:1725-1730
Lu, Jonathan E; Francis, Jasmine H; Dunkel, Ira J et al. (2018) Metastases and death rates after primary enucleation of unilateral retinoblastoma in the USA 2007-2017. Br J Ophthalmol :
Spain, Rebecca I; Liu, Liang; Zhang, Xinbo et al. (2018) Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis. Br J Ophthalmol 102:520-524
Hulett, Tyler W; Jensen, Shawn M; Wilmarth, Phillip A et al. (2018) Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination. J Immunother Cancer 6:27
Boese, Erin A; Huang, David; Tehrani, Shandiz (2018) Unilateral Double Optic Nerve Head Pits. Ophthalmology 125:458
Vranka, Janice A; Staverosky, Julia A; Reddy, Ashok P et al. (2018) Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures. Invest Ophthalmol Vis Sci 59:246-259

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