The Core Grant for Vision Research will further the research goals of 17 vision researchers at the University of Minnesota holding 16 NEI-R01 grants by supporting four service modules. The Visual Testing module will assess visual function in rats, mice and other small animals by measuring the electroretinogram, the visual evoked potential, and the optokinetic response. The module will be managed by a visual testing technician who will maintain the test equipment, provide training to Core Grant investigators and staff, and run tests on experimental animals. The Neuroimaging module will assist investigators who study higher order visual function in humans and non-human primates. The module will provide the services of a neuroimaging specialist and (1) software protocols and hardware for visual stimulus presentation to subjects in magnetic resonance scanners, (2) protocols for identifying retinotopically organized visual areas in the brain, (3) assistance and training for acquiring and analyzing EEG data, and (4) equipment for monitoring subjects'direction of gaze and patterns of eye movements during experiments. The Confocal Microscopy module will provide the services of a confocal specialist who will manage two facilities: (1) a confocal facility utilizing an Olympus FV1000 confocal microscope and a Prairie Technologies two-photon microscope, and (2) an image analysis facility. The Histology module will provide a fully equipped histology laboratory and the services of a histologist. Services include, embedding and sectioning of tissue, staining of sections, immunohistochemistry, in situ cell death detection, in situ hybridization, Q-PCR analysis of RNA, nuclease protection assays, RNA extraction, and protein assays. Each module will be directed by an established investigator holding an NEI-R01 grant. The core grant will be administered by an advisory group comprised of the grant PI and the four module directors.

Public Health Relevance

The Core Grant for Vision Research, by providing research facilities and services to NEI-funded investigators at the University of Minnesota, will advance research into such visual disorders as glaucoma, diabetic retinopathy, macular degeneration, and strabismus.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY011374-17
Application #
8323438
Study Section
Special Emphasis Panel (ZEY1-VSN (05))
Program Officer
Liberman, Ellen S
Project Start
1997-05-01
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
17
Fiscal Year
2012
Total Cost
$510,931
Indirect Cost
$172,566
Name
University of Minnesota Twin Cities
Department
Neurosciences
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Walton, Mark M G; Mustari, Michael J; Willoughby, Christy L et al. (2015) Abnormal activity of neurons in abducens nucleus of strabismic monkeys. Invest Ophthalmol Vis Sci 56:9-Oct
McPherson, Scott W; Heuss, Neal D; Pierson, Mark J et al. (2014) Retinal antigen-specific regulatory T cells protect against spontaneous and induced autoimmunity and require local dendritic cells. J Neuroinflammation 11:205
Wu, Xiaoping; Schmitter, Sebastian; Auerbach, Edward J et al. (2014) Mitigating transmit B 1 inhomogeneity in the liver at 7T using multi-spoke parallel transmit RF pulse design. Quant Imaging Med Surg 4:4-10
Mannion, Damien J; Kersten, Daniel J; Olman, Cheryl A (2014) Regions of mid-level human visual cortex sensitive to the global coherence of local image patches. J Cogn Neurosci 26:1764-74
Heuss, Neal D; Pierson, Mark J; Montaniel, Kim Ramil C et al. (2014) Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice. J Neuroinflammation 11:143
Mariappan, Leo; Hu, Gang; He, Bin (2014) Magnetoacoustic tomography with magnetic induction for high-resolution bioimepedance imaging through vector source reconstruction under the static field of MRI magnet. Med Phys 41:022902
Aarabi, Ardalan; He, Bin (2014) Seizure prediction in hippocampal and neocortical epilepsy using a model-based approach. Clin Neurophysiol 125:930-40
Santoro, Roberta; Moerel, Michelle; De Martino, Federico et al. (2014) Encoding of natural sounds at multiple spectral and temporal resolutions in the human auditory cortex. PLoS Comput Biol 10:e1003412
McDonald, Abby A; Kunz, Matthew D; McLoon, Linda K (2014) Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice. PLoS One 9:e86424
Kur, Joanna; Newman, Eric A (2014) Purinergic control of vascular tone in the retina. J Physiol 592:491-504

Showing the most recent 10 out of 36 publications