This application seeks five years of continued support for an NEI Core Grant that has facilitated the research efforts of vision scientists at the University of California Davis for the past 15 years. The goal is to enhance vision science by providing cost-efficient, stable, and shared resources that are not generally available to individual laboratories. It will enhance collaborations and translational research among a large group of 35 funded vision scientists at UC Davis holding 18 Core-eligible NEI ROI grants. It will also facilitate collection of preliminary data for new grant applications by funded and yet-to-be-funded UC Davis laboratories, and sharing of resources developed for UC Davis with the vision science community outside of our institution. Building on our strengths and new directions in the field, we have redesigned the currently funded cores to better serve the needs of our NEI investigators. The proposed cores are: (i) Software Engineering, (ii) Instrumentation, (iii) Molecular Construct and Packaging, (iv) Tissue Structure and Function, and (v) Small Animal Ocular Imaging. Each core director has one or more NEI ROI grants, and is supported by talented and skilled technical staff. These five cores provide custom facilities and personnel that serve the needs of our NEI investigators and their trainees. The administrative structure includes an Advisory Committee comprised of the principal investigator and the core directors, along with regular input from all vision scientists on campus, and a distinguished group of external advisors. Priorities for use of core facilities have been carefully honed and made available to all investigators. The administration of UC Davis has been, and continues to be, exceptionally supportive of vision research on our campus: This is demonstrated by a substantial increase in the number of vision scientists recruited to our campus and a commensurate increase in NEI-funded grants. This is further buttressed by internal funding of $400,000 as a supplement to this grant, the planned recruitment of new faculty in vision science, and funding for the Center for Visual Sciences, which provides a means for unifying our community of vision researchers, and fostering collaborations with an accomplished cohort of biologists on campus and vision scientists at other institutions.

Public Health Relevance

This Core grant provides shared facilities for an energetic and productive cohort of scientists at the University of California Davis who seek to understand structure and function of the visual system in health and disease. It provides an environment that facilitates collaboration across vision science disciplines and clinical vision science.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Schools of Medicine
United States
Zip Code
Smit-McBride, Zeljka; Forward, Krisztina I; Nguyen, Anthony T et al. (2014) Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye. Mol Vis 20:1569-78
Murphy, Kaitlin C; Morgan, Joshua T; Wood, Joshua A et al. (2014) The formation of cortical actin arrays in human trabecular meshwork cells in response to cytoskeletal disruption. Exp Cell Res 328:164-71
Morgan, Joshua T; Raghunathan, Vijay Krishna; Thomasy, Sara M et al. (2014) Robust and artifact-free mounting of tissue samples for atomic force microscopy. Biotechniques 56:40-2
Smarandache-Wellmann, Carmen; Weller, Cynthia; Mulloney, Brian (2014) Mechanisms of coordination in distributed neural circuits: decoding and integration of coordinating information. J Neurosci 34:793-803
Garland, Shaun P; McKee, Clayton T; Chang, Yow-Ren et al. (2014) A cell culture substrate with biologically relevant size-scale topography and compliance of the basement membrane. Langmuir 30:2101-8
Chang, Yow-Ren; Raghunathan, Vijay Krishna; Garland, Shaun P et al. (2014) Automated AFM force curve analysis for determining elastic modulus of biomaterials and biological samples. J Mech Behav Biomed Mater 37:209-18
Thomasy, Sara M; Raghunathan, Vijay Krishna; Winkler, Moritz et al. (2014) Elastic modulus and collagen organization of the rabbit cornea: epithelium to endothelium. Acta Biomater 10:785-91
Manthey, Abby L; Lachke, Salil A; FitzGerald, Paul G et al. (2014) Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev 131:86-110
Gorouhi, Farzam; Shah, Nihar M; Raghunathan, Vijay Krishna et al. (2014) Epidermal growth factor-functionalized polymeric multilayer films: interplay between spatial location and bioavailability of EGF. J Invest Dermatol 134:1757-60
Garland, Shaun P; Wang, Royal Y; Raghunathan, Vijay Krishna et al. (2014) Photopatternable and photoactive hydrogel for on-demand generation of hydrogen peroxide in cell culture. Biomaterials 35:1762-70

Showing the most recent 10 out of 155 publications