A. Research Plan The Small Animal Ocular Imaging Core (SAOIC) comprises a suite of noninvasive imaging services for living mice and rats, including reflectance and fluorescence fundus imaging with a Micron III mouse digital camera system, optical coherence tomography (OCT), adaptive optics (AO) combined with OCT, scanning laser ophthalmoscopy (SLO) and AO-SLO using custom-built optical systems. These techniques allow widefield to cellular-level resolution imaging of the anterior segment, of the fundus vasculature with fluorescence angiography and phase-variance OCT, and of retinal neuronal and RPE cell structure and function. Mice are the most widely used mammalian model for the investigation of fundamental retinal physiology and cell biology, retinal disease and therapeutics. Noninvasive imaging of mice has become increasingly important in eye research, with commercial instruments such as Phoenix Ltd's Micron III widefield fundus camera (available in our facility) being widely employed. UC Davis has outstanding mouse husbandry facilities, and indeed, has one of the NIH-supported Mutant Mouse Regional Resource Centers (described above). The value of the SAOIC is further enhanced by the Molecular Construct and Packaging Core of this grant, which will provide for the production and packaging of DNA vectors for delivery to the mouse eye either by neonatal injection and iontophoresis, or by viral (AAV) packaging and intravitreal injection.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1)
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University of California Davis
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Azimi, Mina; Le, Tien T; Brown, Nadean L (2018) Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation 102:40-52
Thomasy, Sara M; Raghunathan, Vijay Krishna; Miyagi, Hidetaka et al. (2018) Latrunculin B and substratum stiffness regulate corneal fibroblast to myofibroblast transformation. Exp Eye Res 170:101-107
Miyagi, Hidetaka; Jalilian, Iman; Murphy, Christopher J et al. (2018) Modulation of human corneal stromal cell differentiation by hepatocyte growth factor and substratum compliance. Exp Eye Res 176:235-242
Partida, Gloria J; Fasoli, Anna; Fogli Iseppe, Alex et al. (2018) Autophosphorylated CaMKII Facilitates Spike Propagation in Rat Optic Nerve. J Neurosci 38:8087-8105
Swarup, Aditi; Bell, Brent A; Du, Jianhai et al. (2018) Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Exp Eye Res 172:45-53
Kowalchuk, Angelica M; Maurer, Kate A; Shoja-Taheri, Farnaz et al. (2018) Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis. Dev Biol 442:220-235
Usrey, W Martin; Sherman, S Murray (2018) Corticofugal circuits: Communication lines from the cortex to the rest of the brain. J Comp Neurol :
Failor, Samuel Wilson; Ng, Arash; Cheng, Hwai-Jong (2018) Monocular enucleation alters retinal waves in the surviving eye. Neural Dev 13:4
Yiu, Glenn; Wang, Zhe; Munevar, Christian et al. (2018) Comparison of chorioretinal layers in rhesus macaques using spectral-domain optical coherence tomography and high-resolution histological sections. Exp Eye Res 168:69-76
Smit-McBride, Zeljka; Nguyen, Johnny; Elliott, Garrett W et al. (2018) Effects of aging and environmental tobacco smoke exposure on ocular and plasma circulatory microRNAs in the Rhesus macaque. Mol Vis 24:633-646

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