The purpose of the Biostatistics core is to provide statistical support for clinical, genetic and laboratory studies. This is a new core that is addressing a critical need for statistical support for many of the vision investigators at the Massachusetts Eye and Ear Infirmary (MEEI). A wide variety of studies will be supported by the core ranging from clinical trial design to molecular analyses. The biostatistical expertise and resources provided by the core are targeted to the qualifying ROl projects but are also expected to enhance other ongoing investigations. The core resources will be especially valuable for young investigators who are starting new research projects who would otherwise not have access to biostatistical expertise and resources. The Biostatistics core resources and expert personnel will provide opportunities for collaboration and will stimulate new research ideas and investigations. By helping investigators plan effective investigation and also to efficiently and appropriately analyze experimental data, the biostatistics core will enhance the quality of vision research at MEEI and promote increased productivity of the vision science program. Creating a central facility at MEE will also reduce duplication of efforts as many investigators who will use these resources have similar needs. The availability of the Biostatistics core resources and personnel will likely contribute to the development of new approaches to data analysis which will also benefit the core investigators. Similar to the other cores for this P30 Core grant, the resources provided by this core will broadly impact the translation of basic science discoveries to improve our understanding of the pathogenic features of clinical disease and to develop new therapies and diagnostic modalities. In particular, the availability of the Biostatistics core will draw clinical investigators into research studies, thus enhancing the translation of research discoveries. Overall, access to the Biostatistics core resources is expected to favorably impact the quality of vision research at MEE. The Biostatistics core will be directed by Dr. Pasquale, an epidemiologist with extensive biostatistical experience.

Public Health Relevance

The Biostatistics core of the Massachusetts Eye and Ear Infirmary P30 Center Core Grant for Vision Research will provide resources to help investigators perform a wide variety of statistical analyses that will increase the efficiency and productivity of their investigations on the risk factors and biological processes contributing to blinding eye diseases.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1)
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Liberman, Ellen S
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Massachusetts Eye and Ear Infirmary
United States
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Tian, Bo; Maidana, Daniel E; Dib, Bernard et al. (2016) miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. PLoS One 11:e0160887
Pawlyk, B S; Bulgakov, O V; Sun, X et al. (2016) Photoreceptor rescue by an abbreviated human RPGR gene in a murine model of X-linked retinitis pigmentosa. Gene Ther 23:196-204
Kim, Clifford; Smith, Kaylee E; Castillejos, Alexandra et al. (2016) The alternative complement pathway aids in vascular regression during the early stages of a murine model of proliferative retinopathy. FASEB J 30:1300-5
Dagi Glass, Lora; Sullivan, Ryan; Freitag, Suzanne K (2016) New Translational Research in the Medical Management of Orbital Melanoma. Semin Ophthalmol 31:53-8
Ramke, Mirja; Zhou, Xiaohong; Materne, Emma Caroline et al. (2016) Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis. Exp Eye Res 147:144-7
Greenwald, Scott H; Charette, Jeremy R; Staniszewska, Magdalena et al. (2016) Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease. Am J Pathol 186:1925-38
Bailey, Jessica N Cooke; Loomis, Stephanie J; Kang, Jae H et al. (2016) Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat Genet 48:189-94
Patel, Avni V; Lane, Anne Marie; Morrison, Margaux A et al. (2016) Visual Outcomes after Proton Beam Irradiation for Choroidal Melanomas Involving the Fovea. Ophthalmology 123:369-77
Menon, Balaraj B; Zhou, Xiaohong; Spurr-Michaud, Sandra et al. (2016) Epidemic Keratoconjunctivitis-Causing Adenoviruses Induce MUC16 Ectodomain Release To Infect Ocular Surface Epithelial Cells. mSphere 1:
Zhang, Matthew M; Papakostas, Thanos D; Malcolm, Arnold W et al. (2016) Multiple simultaneous choroidal melanomas arising in the same eye: globe salvage by radiotherapy. Acta Ophthalmol :

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