The purpose of the Biostatistics core is to provide statistical support for clinical, genetic and laboratory studies. This is a new core that is addressing a critical need for statistical support for many of the vision investigators at the Massachusetts Eye and Ear Infirmary (MEEI). A wide variety of studies will be supported by the core ranging from clinical trial design to molecular analyses. The biostatistical expertise and resources provided by the core are targeted to the qualifying ROl projects but are also expected to enhance other ongoing investigations. The core resources will be especially valuable for young investigators who are starting new research projects who would otherwise not have access to biostatistical expertise and resources. The Biostatistics core resources and expert personnel will provide opportunities for collaboration and will stimulate new research ideas and investigations. By helping investigators plan effective investigation and also to efficiently and appropriately analyze experimental data, the biostatistics core will enhance the quality of vision research at MEEI and promote increased productivity of the vision science program. Creating a central facility at MEE will also reduce duplication of efforts as many investigators who will use these resources have similar needs. The availability of the Biostatistics core resources and personnel will likely contribute to the development of new approaches to data analysis which will also benefit the core investigators. Similar to the other cores for this P30 Core grant, the resources provided by this core will broadly impact the translation of basic science discoveries to improve our understanding of the pathogenic features of clinical disease and to develop new therapies and diagnostic modalities. In particular, the availability of the Biostatistics core will draw clinical investigators into research studies, thus enhancing the translation of research discoveries. Overall, access to the Biostatistics core resources is expected to favorably impact the quality of vision research at MEE. The Biostatistics core will be directed by Dr. Pasquale, an epidemiologist with extensive biostatistical experience.

Public Health Relevance

The Biostatistics core of the Massachusetts Eye and Ear Infirmary P30 Center Core Grant for Vision Research will provide resources to help investigators perform a wide variety of statistical analyses that will increase the efficiency and productivity of their investigations on the risk factors and biological processes contributing to blinding eye diseases.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
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Massachusetts Eye and Ear Infirmary
United States
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Jamshidi, Farzad; Place, Emily M; Mehrotra, Sudeep et al. (2018) Contribution of noncoding pathogenic variants to RPGRIP1-mediated inherited retinal degeneration. Genet Med :
Lee, Jeong Yoon; Lee, Ji Sun; Materne, Emma C et al. (2018) Bacterial RecA Protein Promotes Adenoviral Recombination during In Vitro Infection. mSphere 3:
Kosmidou, Cassandra; Efstathiou, Nikolaos E; Hoang, Mien V et al. (2018) Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep 8:461
Ismail, Ashrafali M; Lee, Ji Sun; Lee, Jeong Yoon et al. (2018) Adenoviromics: Mining the Human Adenovirus Species D Genome. Front Microbiol 9:2178
Bauer, Corinna M; Cattaneo, Zaira; Merabet, Lotfi B (2018) Early blindness is associated with increased volume of the uncinate fasciculus. Eur J Neurosci 47:427-432
Bailey, Jessica N Cooke; Gharahkhani, Puya; Kang, Jae H et al. (2018) Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets. Invest Ophthalmol Vis Sci 59:629-636
Fernandez-Godino, Rosario; Bujakowska, Kinga M; Pierce, Eric A (2018) Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway. Hum Mol Genet 27:147-159
Ismail, Ashrafali M; Cui, Tiange; Dommaraju, Kalpana et al. (2018) Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens. Emerg Microbes Infect 7:10
Choi, Hee Joo; Wang, Rui; Jakobs, Tatjana C (2018) Single-Cell Dissociation and Characterization in the Murine Retina and Optic Nerve. Methods Mol Biol 1695:311-334
Paschalis, Eleftherios I; Lei, Fengyang; Zhou, Chengxin et al. (2018) Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes. Proc Natl Acad Sci U S A 115:E11359-E11368

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