The purpose of the Biostatistics core is to provide statistical support for clinical, genetic and laboratory studies. This is a new core that is addressing a critical need for statistical support for many of the vision investigators at the Massachusetts Eye and Ear Infirmary (MEEI). A wide variety of studies will be supported by the core ranging from clinical trial design to molecular analyses. The biostatistical expertise and resources provided by the core are targeted to the qualifying ROl projects but are also expected to enhance other ongoing investigations. The core resources will be especially valuable for young investigators who are starting new research projects who would otherwise not have access to biostatistical expertise and resources. The Biostatistics core resources and expert personnel will provide opportunities for collaboration and will stimulate new research ideas and investigations. By helping investigators plan effective investigation and also to efficiently and appropriately analyze experimental data, the biostatistics core will enhance the quality of vision research at MEEI and promote increased productivity of the vision science program. Creating a central facility at MEE will also reduce duplication of efforts as many investigators who will use these resources have similar needs. The availability of the Biostatistics core resources and personnel will likely contribute to the development of new approaches to data analysis which will also benefit the core investigators. Similar to the other cores for this P30 Core grant, the resources provided by this core will broadly impact the translation of basic science discoveries to improve our understanding of the pathogenic features of clinical disease and to develop new therapies and diagnostic modalities. In particular, the availability of the Biostatistics core will draw clinical investigators into research studies, thus enhancing the translation of research discoveries. Overall, access to the Biostatistics core resources is expected to favorably impact the quality of vision research at MEE. The Biostatistics core will be directed by Dr. Pasquale, an epidemiologist with extensive biostatistical experience.

Public Health Relevance

The Biostatistics core of the Massachusetts Eye and Ear Infirmary P30 Center Core Grant for Vision Research will provide resources to help investigators perform a wide variety of statistical analyses that will increase the efficiency and productivity of their investigations on the risk factors and biological processes contributing to blinding eye diseases.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts Eye and Ear Infirmary
United States
Zip Code
Loomis, Stephanie J; Kang, Jae H; Weinreb, Robert N et al. (2014) Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss. Ophthalmology 121:508-16
Yanai, Ryoji; Mulki, Lama; Hasegawa, Eiichi et al. (2014) Cytochrome P450-generated metabolites derived from ?-3 fatty acids attenuate neovascularization. Proc Natl Acad Sci U S A 111:9603-8
Wiggs, Janey L; Pawlyk, Basil; Connolly, Edward et al. (2014) Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1). Invest Ophthalmol Vis Sci 55:856-64
Hasegawa, Eiichi; Sweigard, Harry; Husain, Deeba et al. (2014) Characterization of a spontaneous retinal neovascular mouse model. PLoS One 9:e106507
Isayama, Tomoki; Chen, Ying; Kono, Masahiro et al. (2014) Coexpression of three opsins in cone photoreceptors of the salamander Ambystoma tigrinum. J Comp Neurol 522:2249-65
Matsumoto, H; Murakami, Y; Kataoka, K et al. (2014) Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment. Cell Death Dis 5:e1269
Takeuchi, Kimio; Yanai, Ryoji; Kumase, Fumiaki et al. (2014) EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay. PLoS One 9:e91849
Kang, J H; Loomis, S J; Yaspan, B L et al. (2014) Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma. Eye (Lond) 28:662-71
Bailey, Jessica N Cooke; Yaspan, Brian L; Pasquale, Louis R et al. (2014) Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. Hum Genet 133:1319-30
Matsumoto, Hidetaka; Kataoka, Keiko; Tsoka, Pavlina et al. (2014) Strain difference in photoreceptor cell death after retinal detachment in mice. Invest Ophthalmol Vis Sci 55:4165-74

Showing the most recent 10 out of 164 publications