Vision research at the University of Utah engages over 17 faculty members and 50+ supporting staff, graduate students and postdoctoral fellows. This proposal for a Vision Research Core Grant will enhance the programs of twelve participating investigators who collectively hold fifteen R01 awards from the National Eye Institute. The Core consists of (1) Imaging, (2) Functional Assessment, and (3) Molecular Biology modules, providing comprehensive resources, training and technical assistance to the programs of the participating investigators. In addition, a novel client-server application (iLab) will provide secure, uniform workflow and data management for all modules, facilitating access, conflict resolution, job scheduling and data tracking. This tool assures data integrity and any dataset can be collaboratively accessed. The Imaging Module will provide: (1) high-resolution optical imaging with high-speed image capture; (2) laser confocal scanning microscopy (LSCM); (3) electron microscopy (EM) with high-resolution digital capture; (4) computational fusion of optical, LSCM, and EM data; (5) ultramicrotomy cryomicrotomy services, including immunocytochemistry; (6) training; (7) resource maintenance; and (8) comprehensive data archiving. The Functional Assessment Module will provide: (1) comprehensive ERG/VEP visual testing; (2) optomotor behavioral tracking; (3) optical imaging of intrinsic CMS signals; (4) optical system calibration; (5) training; (6) resource maintenance; and (8) comprehensive data archiving. The Molecular Biology Module will provide: (1) high-capacity gene sequencing (2) robotics for sample processing; (3) IR imaging of blots and gels; (4) high-capacity ISH screening (5) training; (6) resource maintenance; and (7) comprehensive data archiving. Access to new technologies, training and technical support will facilitate collaborations, allow participating investigators to explore new research avenues and funding opportunities, and enhance the educational experience of graduate students, medical students, interns, residents and postdoctoral fellows.
| Usher, Will; Klacansky, Pavol; Federer, Frederick et al. (2018) A Virtual Reality Visualization Tool for Neuron Tracing. IEEE Trans Vis Comput Graph 24:994-1003 |
| Marc, Robert E; Sigulinsky, Crystal Lynn; Pfeiffer, Rebecca L et al. (2018) Heterocellular Coupling Between Amacrine Cells and Ganglion Cells. Front Neural Circuits 12:90 |
| Choi, Rene; Gorusupudi, Aruna; Bernstein, Paul S (2018) Long-term follow-up of autosomal dominant Stargardt macular dystrophy (STGD3) subjects enrolled in a fish oil supplement interventional trial. Ophthalmic Genet 39:307-313 |
| Hanke-Gogokhia, Christin; Frederick, Jeanne M; Zhang, Houbin et al. (2018) Binary Function of ARL3-GTP Revealed by Gene Knockouts. Adv Exp Med Biol 1074:317-325 |
| Simmons, Aaron B; Bretz, Colin A; Wang, Haibo et al. (2018) Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy. Angiogenesis 21:751-764 |
| Deng, Wen-Tao; Li, Jie; Zhu, Ping et al. (2018) Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy. Mol Vis 24:17-28 |
| Andersen, Karl M; Sauer, Lydia; Gensure, Rebekah H et al. (2018) Characterization of Retinitis Pigmentosa Using Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). Transl Vis Sci Technol 7:20 |
| Yarishkin, Oleg; Phuong, Tam T T; Bretz, Colin A et al. (2018) TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells. J Gen Physiol 150:1660-1675 |
| Elias, Eerik; Yang, Ning; Wang, Ping et al. (2018) Glutamate Activity Regulates and Dendritic Development of J-RGCs. Front Cell Neurosci 12:249 |
| Nurminen, Lauri; Merlin, Sam; Bijanzadeh, Maryam et al. (2018) Top-down feedback controls spatial summation and response amplitude in primate visual cortex. Nat Commun 9:2281 |
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