Vision research at the University of Utah engages over 19 faculty members and 60+ supporting staff, graduate students and postdoctoral fellows. This proposal for a Vision Research Core (VRC) Grant will enhance the programs of thirteen participating investigators who collectively hold sixteen R0l awards and one R24 award from the National Eye Institute. The VRC consists of (1) Imaging, (2) Histomics, (3) Physiology, and (3) Biochemistry modules, providing comprehensive resources, training and technical assistance to the programs of the participating investigators. These programs are integrated by a Moran Research data center with over 50 terabytes of capacity, expandable to 500 terabytes. The Imaging Module provides: (1) Ultra-speed computational transmission electron microscope (TEM) imaging services;(2) laser confocal imaging;(3) high-resolution, high-speed scanning optical imaging;(4) computational fusion of optical, LSCM, and EM data;(5) tissue processing and ultramicrotomy services;(7) extensive imaging software libraries;(8) and enterprise-scale data archiving. The Histomics Module provides: (1) Genotyping services;(2) Embryo and sperm cryopreservation services;and (3) Cryotomy resources. The Physiology Module provides: (1) ERG visual testing;(2) "OptoMotry" behavioral tracking;(3) Heidelberg Spectralis OCT imaging;and (4) Real-time Micron mouse fundus imaging. The Biochemistry Module provides: (1) Ultracentrifugation;(2) Protein quantification (Odyssey imaging);(3) Electroporation;(4) HPLC/MS and GC/MS services;(5) SensiQ surface plasmon resonance molecular interaction profiling. Access to both novel and established technologies, along with technical support, will facilitate collaborations, allow investigators to expand into new research avenues, enable new funding ventures, and enhance the educational experience of graduate students, medical students, interns, residents and postdoctoral fellows.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Application #
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
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University of Utah
Schools of Medicine
Salt Lake City
United States
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Vachali, Preejith P; Li, Binxing; Bartschi, Alexis et al. (2015) Surface plasmon resonance (SPR)-based biosensor technology for the quantitative characterization of protein-carotenoid interactions. Arch Biochem Biophys 572:66-72
Zhang, Tao; Enemchukwu, Nduka O; Jones, Alex et al. (2015) Genetic deletion of S-opsin prevents rapid cone degeneration in a mouse model of Leber congenital amaurosis. Hum Mol Genet 24:1755-63
Deering-Rice, Cassandra E; Mitchell, Virginia K; Romero, Erin G et al. (2014) Drofenine: A 2-APB Analogue with Greater Selectivity for Human TRPV3. Pharmacol Res Perspect 2:e00062
Fu, Yingbin (2014) A functional approach to examine the role of HTRA1 versus ARMS2 in AMD. Invest Ophthalmol Vis Sci 55:6524
Zhang, Houbin; Frederick, Jeanne M; Baehr, Wolfgang (2014) Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones. Adv Exp Med Biol 801:487-93
Finger, Robert P; Wu, Zhichao; Luu, Chi D et al. (2014) Reticular pseudodrusen: a risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization. Ophthalmology 121:1252-6
Cho, Yang Kyung; Archer, Bonnie; Ambati, Balamurali K (2014) Dry eye predisposes to corneal neovascularization and lymphangiogenesis after corneal injury in a murine model. Cornea 33:621-7
Zou, Junhuang; Zheng, Tihua; Ren, Chongyu et al. (2014) Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Hum Mol Genet 23:2374-90
Krizaj, David; Ryskamp, Daniel A; Tian, Ning et al. (2014) From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma. Curr Eye Res 39:105-19
Xu, Hong-Ping; Sun, Jin Hao; Tian, Ning (2014) A general principle governs vision-dependent dendritic patterning of retinal ganglion cells. J Comp Neurol 522:3403-22

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