The OVERALL aims of this Vision Research Core (VRC) are to provide: access to resources outside the scope of individual R01 awards access to technical expertise outside the scope a single laboratory staff training to remove barriers to efficient translational research and collaboration The research areas supported by the VRC span the analysis and treatments of retinal degenerations, developmental disorders, glaucoma and other disorders, as well as and a range of cutting-edge basic science initiatives. We have implemented four resource modules that continue the natural evolution of how this research group works together, serving 15 investigators holding 21 NEI R01 awards. The Histomics Module derives from the strengths in mouse genetics at the Moran Eye Center and the high demand for tissue profiling. Almost every JMEC laboratory has need of high quality ?histomics? (cryosectioning, paratoming, genotyping, immunocytochemistry, PCR, ISH). Specifically the Histomics module provides: High-quality cryotomy resources through two professionally maintained Leica CM3050S systems Paraffin embedding and section services via a new Leica Paratome PCR and genotyping services Mouse line cryopreservation services

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY014800-12
Application #
9123600
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
12
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Marc, Robert E; Sigulinsky, Crystal Lynn; Pfeiffer, Rebecca L et al. (2018) Heterocellular Coupling Between Amacrine Cells and Ganglion Cells. Front Neural Circuits 12:90
Choi, Rene; Gorusupudi, Aruna; Bernstein, Paul S (2018) Long-term follow-up of autosomal dominant Stargardt macular dystrophy (STGD3) subjects enrolled in a fish oil supplement interventional trial. Ophthalmic Genet 39:307-313
Hanke-Gogokhia, Christin; Frederick, Jeanne M; Zhang, Houbin et al. (2018) Binary Function of ARL3-GTP Revealed by Gene Knockouts. Adv Exp Med Biol 1074:317-325
Simmons, Aaron B; Bretz, Colin A; Wang, Haibo et al. (2018) Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy. Angiogenesis 21:751-764
Deng, Wen-Tao; Li, Jie; Zhu, Ping et al. (2018) Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy. Mol Vis 24:17-28
Andersen, Karl M; Sauer, Lydia; Gensure, Rebekah H et al. (2018) Characterization of Retinitis Pigmentosa Using Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). Transl Vis Sci Technol 7:20
Yarishkin, Oleg; Phuong, Tam T T; Bretz, Colin A et al. (2018) TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells. J Gen Physiol 150:1660-1675
Elias, Eerik; Yang, Ning; Wang, Ping et al. (2018) Glutamate Activity Regulates and Dendritic Development of J-RGCs. Front Cell Neurosci 12:249
Nurminen, Lauri; Merlin, Sam; Bijanzadeh, Maryam et al. (2018) Top-down feedback controls spatial summation and response amplitude in primate visual cortex. Nat Commun 9:2281
Bretz, Colin A; Divoky, Vladimir; Prchal, Josef et al. (2018) Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization. Sci Rep 8:2161

Showing the most recent 10 out of 372 publications