The Salk Institute for Biological Studies requests support for a new Core Grant for Vision Research. Vision research at the Salk Institute has grown considerably over the past two decades and the vision core faculty now includes 15 research laboratories, 10 currently funded through 13 R01 grant awards from the National Eye Institute. These vision science investigators come from several different Salk Institute departments, including the Vision Center, Computational Neurobiology, Molecular Neurobiology, Regulatory Biology and Systems Neurobiology Laboratories, and the Laboratory for Cognitive Neuroscience. Vision research at the Salk Institute covers broad areas of interest, including visual system development and plasticity, understanding the mechanisms of the neural processing of visual stimuli, visual perception and their link to behaviors, and pathology. The NEI P30 Core Grant will enable the establishment of four Modules that are critical in support of these efforts: 1) Molecular Biology and Virology Module, 2) Non-Human Primate Facility Module, 3) Machine Shop Module, and 4) Advanced Computing Module. Each of the modules will have significant use by at least seven core investigators, with the Machine Shop and Advanced Computing Modules supporting all members of the core. NEI support for the Salk Vision Core will help to foster new interdisciplinary collaborations, supporting and enhancing the significant synergies that exist between these research efforts and providing the basis for the development of new projects and research programs. Core support will also provide significant leverage for the Salk Institute to stimulate outside philanthropy and to recruit trainees and other new investigators, further expanding vision research at the Salk Institute and advancing the mission of the National Eye Institute.

Public Health Relevance

Understanding the mechanisms by which visual inputs are processed from the retina to the brain and lead to changes in behavior as organisms interact with their environment provides a model system for understanding the central nervous system. Center programs include study of clinical disorders of visual perception such as Williams Syndrome and projects to develop prosthetics restoring vision to the blind.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY019005-04
Application #
8311031
Study Section
Special Emphasis Panel (ZEY1-VSN (08))
Program Officer
Liberman, Ellen S
Project Start
2009-07-01
Project End
2014-06-30
Budget Start
2012-09-01
Budget End
2013-06-30
Support Year
4
Fiscal Year
2012
Total Cost
$757,600
Indirect Cost
$357,600
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Chaix, Amandine; Zarrinpar, Amir; Miu, Phuong et al. (2014) Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab 20:991-1005
Hatori, Megumi; Gill, Shubhroz; Mure, Ludovic S et al. (2014) Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. Elife 3:e03357
Disney, Anita A; Reynolds, John H (2014) Expression of m1-type muscarinic acetylcholine receptors by parvalbumin-immunoreactive neurons in the primary visual cortex: a comparative study of rat, guinea pig, ferret, macaque, and human. J Comp Neurol 522:986-1003
Cruz-Martín, Alberto; El-Danaf, Rana N; Osakada, Fumitaka et al. (2014) A dedicated circuit links direction-selective retinal ganglion cells to the primary visual cortex. Nature 507:358-61
Zarrinpar, Amir; Chaix, Amandine; Yooseph, Shibu et al. (2014) Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metab 20:1006-17
Dhande, Onkar S; Estevez, Maureen E; Quattrochi, Lauren E et al. (2013) Genetic dissection of retinal inputs to brainstem nuclei controlling image stabilization. J Neurosci 33:17797-813
Gepshtein, Sergei; Lesmes, Luis A; Albright, Thomas D (2013) Sensory adaptation as optimal resource allocation. Proc Natl Acad Sci U S A 110:4368-73