Columbia University has a large and vibrant vision research community supported by the National Eye Institute, with 20 qualifying grants. Vision research at Columbia ranges across a huge gamut of topics, from genetic studies of retinal and visual brain development in Drosophila and mice to epidemiological studies of the behavior of patients with eye disease. Computational, neurophysiological, light and electron microscopic, genetic, biochemical, and clinical techniques focus on a range of problems including the development of the eye and the visual brain, the mechanisms of ocular angiogenesis, the systems neuroscience of visual and oculomotor behavior, and the pathophysiology and treatment of retinal diseases such as macular degeneration. To support this vision research we are requesting the establishment of a National Eye Institute supported set of Core Facilities for Vision Research, to provide services that could not be provided by individual research grants. The proposed core will have three modules: a instrumentation fabrication and design module which will be the successor of a similar module which was funded by an NEI program which cannot be renewed;a computer support module which will include offsite data backup, support and maintenance for the hundreds of computers, including an X-grid cluster, used by the vision research community, and a microscopic imaging module which will provide histological and in vivo and fluorescent microscopy services. This core will also facilitate collaboration among members of the Columbia vision research community, and encourage scientists not currently engaged in vision research to use their expertise to solve problems related to vision.
Vision is a unique process, depending upon both the eye and the brain. This Core Facilities grant will support work on basic and clinical aspects of vision research, from understanding how the eye and the visual brain develop, to the treatment of macular degeneration and the behavior of patients with ocular disease. By providing technical support, this core will enable its investigators to work effectively on problems related to the causes and treatment of blindness.
|Velez, Gabriel; Tsang, Stephen H; Tsai, Yi-Ting et al. (2017) Gene Therapy Restores Mfrp and Corrects Axial Eye Length. Sci Rep 7:16151|
|Wang, Yong; Kim, Hye Jin; Sparrow, Janet R (2017) Quercetin and cyanidin-3-glucoside protect against photooxidation and photodegradation of A2E in retinal pigment epithelial cells. Exp Eye Res 160:45-55|
|Sengillo, Jesse D; Cabral, Thiago; Schuerch, Kaspar et al. (2017) Electroretinography Reveals Difference in Cone Function between Syndromic and Nonsyndromic USH2A Patients. Sci Rep 7:11170|
|Pahl, Daniel A; Green, Nancy S; Bhatia, Monica et al. (2017) New Ways to Detect Pediatric Sickle Cell Retinopathy: A Comprehensive Review. J Pediatr Hematol Oncol 39:618-625|
|Lin, James; Boudreault, Katherine; Tsang, Stephen (2017) MULTIMODAL IMAGING AND ELECTRORETINOGRAPHY IN LONG-CHAIN 3-HYDROXYACYL COENZYME A DEHYDROGENASE DEFICIENCY. Retin Cases Brief Rep 11 Suppl 1:S107-S112|
|Garg, Aakriti; Yang, Jin; Lee, Winston et al. (2017) Stem Cell Therapies in Retinal Disorders. Cells 6:|
|Zyablitskaya, Mariya; Takaoka, Anna; Munteanu, Emilia L et al. (2017) Evaluation of Therapeutic Tissue Crosslinking (TXL) for Myopia Using Second Harmonic Generation Signal Microscopy in Rabbit Sclera. Invest Ophthalmol Vis Sci 58:21-29|
|Cho, Galaxy Y; Abdulla, Yazeed; Sengillo, Jesse D et al. (2017) CRISPR-mediated Ophthalmic Genome Surgery. Curr Ophthalmol Rep 5:199-206|
|Ciccone, Lyam; Lee, Winston; Zernant, Jana et al. (2017) HYPERREFLECTIVE DEPOSITION IN THE BACKGROUND OF ADVANCED STARGARDT DISEASE. Retina :|
|Toral, Marcus A; Velez, Gabriel; Boudreault, Katherine et al. (2017) Structural modeling of a novel SLC38A8 mutation that causes foveal hypoplasia. Mol Genet Genomic Med 5:202-209|
Showing the most recent 10 out of 249 publications