Columbia University has a large and vibrant vision research community supported by the National Eye Institute, with 20 qualifying grants. Vision research at Columbia ranges across a huge gamut of topics, from genetic studies of retinal and visual brain development in Drosophila and mice to epidemiological studies of the behavior of patients with eye disease. Computational, neurophysiological, light and electron microscopic, genetic, biochemical, and clinical techniques focus on a range of problems including the development of the eye and the visual brain, the mechanisms of ocular angiogenesis, the systems neuroscience of visual and oculomotor behavior, and the pathophysiology and treatment of retinal diseases such as macular degeneration. To support this vision research we are requesting the establishment of a National Eye Institute supported set of Core Facilities for Vision Research, to provide services that could not be provided by individual research grants. The proposed core will have three modules: a instrumentation fabrication and design module which will be the successor of a similar module which was funded by an NEI program which cannot be renewed;a computer support module which will include offsite data backup, support and maintenance for the hundreds of computers, including an X-grid cluster, used by the vision research community, and a microscopic imaging module which will provide histological and in vivo and fluorescent microscopy services. This core will also facilitate collaboration among members of the Columbia vision research community, and encourage scientists not currently engaged in vision research to use their expertise to solve problems related to vision.

Public Health Relevance

Vision is a unique process, depending upon both the eye and the brain. This Core Facilities grant will support work on basic and clinical aspects of vision research, from understanding how the eye and the visual brain develop, to the treatment of macular degeneration and the behavior of patients with ocular disease. By providing technical support, this core will enable its investigators to work effectively on problems related to the causes and treatment of blindness.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30EY019007-05
Application #
8698753
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10032
Li, Xia; Li, Yongjun; Kim, Mijung et al. (2014) Aliphatic *-nitroalcohols for therapeutic corneoscleral cross-linking: chemical stability studies using 1H-NMR spectroscopy. Photochem Photobiol 90:338-43
Wu, Li; Ueda, Keiko; Nagasaki, Taka et al. (2014) Light damage in Abca4 and Rpe65rd12 mice. Invest Ophthalmol Vis Sci 55:1910-8
Bhansali, Punita; Rayport, Ilana; Rebsam, Alexandra et al. (2014) Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice. Neural Dev 9:11
Urs, Raksha; Lloyd, Harriet O; Silverman, Ronald H (2014) Acoustic radiation force for noninvasive evaluation of corneal biomechanical changes induced by cross-linking therapy. J Ultrasound Med 33:1417-26
Zernant, Jana; Collison, Frederick T; Lee, Winston et al. (2014) Genetic and clinical analysis of ABCA4-associated disease in African American patients. Hum Mutat 35:1187-94
Kaufman, Matthew T; Churchland, Mark M; Ryu, Stephen I et al. (2014) Cortical activity in the null space: permitting preparation without movement. Nat Neurosci 17:440-8
Nong, Eva; Lee, Winston; Merriam, Joanna E et al. (2014) Disease progression in autosomal dominant cone-rod dystrophy caused by a novel mutation (D100G) in the GUCA1A gene. Doc Ophthalmol 128:59-67
Garg, Aakriti; Wapner, Ronald J; Ananth, Cande V et al. (2014) Choroidal and retinal thickening in severe preeclampsia. Invest Ophthalmol Vis Sci 55:5723-9
Wert, Katherine J; Skeie, Jessica M; Bassuk, Alexander G et al. (2014) Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina. Hum Mol Genet 23:2665-77
Tsang, Stephen H; Burke, Tomas; Oll, Maris et al. (2014) Whole exome sequencing identifies CRB1 defect in an unusual maculopathy phenotype. Ophthalmology 121:1773-82

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