A Core Center Grant is proposed to support vision research at the University of Texas Southwestern Medical Center. Investigators in the Department of Ophthalmology recently completed a 5-year infrastructure grant (R24) that supported ocular surface research on our campus. The infrastructure grant was enormously successful and fostered new collaborations and culminated in 69 publications in peer-review journals. We recently received a one-year P30 Core Grant through the ARRA. This unique one-year award has fostered further collaborations among vision researchers from the Departments of Ophthalmology, Psychiatry, Physiology, Neuroscience, and the Center for Developmental Biology at the University of Texas Southwestern Medical Center. We have also initiated a number of vision-related projects and seminar series that have enriched vision research activities on this campus. This, along with the acquisition of additional NEl-supported research, prompted us to submit a 5-year P30 Core Grant application to enhance and expand research efforts that rely on three common technologies: 1) tissue culture/hybridoma;2) imaging;and 3) protein biochemistry and virus-mediated gene transfer. Significant institutional support in the form of additional laboratory space, endowed scholars'awards, and intramural research awards has provided a fertile ground for expansion and enhancement of vision research on our campus. The proposed Core Grant for Vision Research will further this effort and enhance vision research at the University of Texas Southwestern Medical Center.

Public Health Relevance

We anticipate three tangible benefits from this core grant: 1) vision scientists at U.T. Southwestern Medical Center will have more and scientifically stronger publications;2) the number of vision science investigators at U.T. Southwestern Medical Center will increase;and 3) the quantity and quality of visual science graduate students and postdocs at U.T. Southwestern Medical Center will increase.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1-VSN (05))
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Liberman, Ellen S
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University of Texas Sw Medical Center Dallas
Schools of Medicine
United States
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Robertson, Danielle M; Alexander, Larry J; Bonanno, Joseph A et al. (2014) Cornea and ocular surface disease: application of cutting-edge optometric research. Optom Vis Sci 91:S3-16
Cai, Daniel; Zhu, Meifang; Petroll, W Matthew et al. (2014) The impact of type 1 diabetes mellitus on corneal epithelial nerve morphology and the corneal epithelium. Am J Pathol 184:2662-70
Xing, Chao; Gong, Xin; Hussain, Imran et al. (2014) Transethnic replication of association of CTG18.1 repeat expansion of TCF4 gene with Fuchs' corneal dystrophy in Chinese implies common causal variant. Invest Ophthalmol Vis Sci 55:7073-8
Mootha, V Vinod; Gong, Xin; Ku, Hung-Chih et al. (2014) Association and familial segregation of CTG18.1 trinucleotide repeat expansion of TCF4 gene in Fuchs' endothelial corneal dystrophy. Invest Ophthalmol Vis Sci 55:33-42
McMahon, Anne; Lu, Hua; Butovich, Igor A (2014) A role for ELOVL4 in the mouse meibomian gland and sebocyte cell biology. Invest Ophthalmol Vis Sci 55:2832-40
Posch, Leila C; Zhu, Meifang; Robertson, Danielle M (2014) Multipurpose care solution-induced corneal surface disruption and Pseudomonas aeruginosa internalization in the rabbit corneal epithelium. Invest Ophthalmol Vis Sci 55:4229-37
Wei, Cynthia; Zhu, Meifang; Petroll, W Matthew et al. (2014) Pseudomonas aeruginosa infectious keratitis in a high oxygen transmissible rigid contact lens rabbit model. Invest Ophthalmol Vis Sci 55:5890-9
Butovich, Igor A; Lu, Hua; McMahon, Anne et al. (2014) Biophysical and morphological evaluation of human normal and dry eye meibum using hot stage polarized light microscopy. Invest Ophthalmol Vis Sci 55:87-101
Coursey, Terry G; Bohat, Ritu; Barbosa, Flavia L et al. (2014) Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-? in experimental dry eye. J Immunol 193:5264-72
Ali, Zahra; Xing, Chao; Anwar, Didar et al. (2014) A novel de novo KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Möbius syndrome. Mol Vis 20:368-75

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