A Core Center Grant is proposed to support vision research at the University of Texas Southwestern Medical Center. Investigators in the Department of Ophthalmology recently completed a 5-year infrastructure grant (R24) that supported ocular surface research on our campus. The infrastructure grant was enormously successful and fostered new collaborations and culminated in 69 publications in peer-review journals. We recently received a one-year P30 Core Grant through the ARRA. This unique one-year award has fostered further collaborations among vision researchers from the Departments of Ophthalmology, Psychiatry, Physiology, Neuroscience, and the Center for Developmental Biology at the University of Texas Southwestern Medical Center. We have also initiated a number of vision-related projects and seminar series that have enriched vision research activities on this campus. This, along with the acquisition of additional NEl-supported research, prompted us to submit a 5-year P30 Core Grant application to enhance and expand research efforts that rely on three common technologies: 1) tissue culture/hybridoma;2) imaging;and 3) protein biochemistry and virus-mediated gene transfer. Significant institutional support in the form of additional laboratory space, endowed scholars'awards, and intramural research awards has provided a fertile ground for expansion and enhancement of vision research on our campus. The proposed Core Grant for Vision Research will further this effort and enhance vision research at the University of Texas Southwestern Medical Center.
We anticipate three tangible benefits from this core grant: 1) vision scientists at U.T. Southwestern Medical Center will have more and scientifically stronger publications;2) the number of vision science investigators at U.T. Southwestern Medical Center will increase;and 3) the quantity and quality of visual science graduate students and postdocs at U.T. Southwestern Medical Center will increase.
|Xiao, Yangyan; de Paiva, Cintia S; Yu, Zhiyuan et al. (2018) Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol 30:457-470|
|Titone, Rossella; Zhu, Meifang; Robertson, Danielle M (2018) Insulin mediates de novo nuclear accumulation of the IGF-1/insulin Hybrid Receptor in corneal epithelial cells. Sci Rep 8:4378|
|Datta, Shyamtanu; Renwick, Marian; Chau, Viet Q et al. (2018) A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye - Implications for Ocular Gene Therapy. Invest Ophthalmol Vis Sci 59:4909-4920|
|Wong, Madeline Y; Doan, Ngoc Duc; DiChiara, Andrew S et al. (2018) A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production. Biochemistry 57:2814-2827|
|Zhou, Scott; Robertson, Danielle M (2018) Wide-Field In Vivo Confocal Microscopy of Meibomian Gland Acini and Rete Ridges in the Eyelid Margin. Invest Ophthalmol Vis Sci 59:4249-4257|
|Saade, Joanna S; Xing, Chao; Gong, Xin et al. (2018) Instability of TCF4 Triplet Repeat Expansion With Parent-Child Transmission in Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci 59:4065-4070|
|Patel, Roshni; Zhu, Meifang; Robertson, Danielle M (2018) Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye. Growth Horm IGF Res 40:69-73|
|Hu, Jiaxin; Rong, Ziye; Gong, Xin et al. (2018) Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs' dystrophy. Hum Mol Genet 27:1015-1026|
|Truong, David T; Bui, Minh-Thuy; Cavanagh, H Dwight (2018) Epidemiology and Outcome of Microbial Keratitis: Private University Versus Urban Public Hospital Care. Eye Contact Lens 44 Suppl 1:S82-S86|
|Neelam, Sudha; Mellon, Jessamee; Wilkerson, Amber et al. (2018) Induction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation. Invest Ophthalmol Vis Sci 59:4738-4747|
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