A Core Center Grant is proposed to support vision research at the University of Texas Southwestern Medical Center. Investigators in the Department of Ophthalmology recently completed a 5-year infrastructure grant (R24) that supported ocular surface research on our campus. The infrastructure grant was enormously successful and fostered new collaborations and culminated in 69 publications in peer-review journals. We recently received a one-year P30 Core Grant through the ARRA. This unique one-year award has fostered further collaborations among vision researchers from the Departments of Ophthalmology, Psychiatry, Physiology, Neuroscience, and the Center for Developmental Biology at the University of Texas Southwestern Medical Center. We have also initiated a number of vision-related projects and seminar series that have enriched vision research activities on this campus. This, along with the acquisition of additional NEl-supported research, prompted us to submit a 5-year P30 Core Grant application to enhance and expand research efforts that rely on three common technologies: 1) tissue culture/hybridoma;2) imaging;and 3) protein biochemistry and virus-mediated gene transfer. Significant institutional support in the form of additional laboratory space, endowed scholars'awards, and intramural research awards has provided a fertile ground for expansion and enhancement of vision research on our campus. The proposed Core Grant for Vision Research will further this effort and enhance vision research at the University of Texas Southwestern Medical Center.

Public Health Relevance

We anticipate three tangible benefits from this core grant: 1) vision scientists at U.T. Southwestern Medical Center will have more and scientifically stronger publications;2) the number of vision science investigators at U.T. Southwestern Medical Center will increase;and 3) the quantity and quality of visual science graduate students and postdocs at U.T. Southwestern Medical Center will increase.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1-VSN (05))
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Liberman, Ellen S
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University of Texas Sw Medical Center Dallas
Schools of Medicine
United States
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Stern, Michael E; Pflugfelder, Stephen C (2017) What We Have Learned From Animal Models of Dry Eye. Int Ophthalmol Clin 57:109-118
Butovich, Igor A (2017) Meibomian glands, meibum, and meibogenesis. Exp Eye Res 163:2-16
Vu, Khiem T; Zhang, Fang; Hulleman, John D (2017) Conditional, Genetically Encoded, Small Molecule-Regulated Inhibition of NF?B Signaling in RPE Cells. Invest Ophthalmol Vis Sci 58:4126-4137
Bian, Fang; Xiao, Yangyan; Zaheer, Mahira et al. (2017) Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int J Mol Sci 18:
Hinojosa, Jorge A; Patel, Naiya B; Zhu, Meifang et al. (2017) Antimicrobial Efficacy of Contact Lens Care Solutions Against Neutrophil-Enhanced Bacterial Biofilms. Transl Vis Sci Technol 6:11
Stuard, Whitney L; Gallerson, Bryan K; Robertson, Danielle M (2017) Alterations in corneal nerves following crack cocaine use mimic diabetes-induced nerve damage. Endocrinol Diabetes Metab Case Rep 2017:
Ding, Yi; Aredo, Bogale; Zhong, Xin et al. (2017) Increased susceptibility to fundus camera-delivered light-induced retinal degeneration in mice deficient in oxidative stress response proteins. Exp Eye Res 159:58-68
Pflugfelder, Stephen C; de Paiva, Cintia S (2017) The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology 124:S4-S13
Mootha, V Vinod; Hansen, Brock; Rong, Ziye et al. (2017) Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy. Invest Ophthalmol Vis Sci 58:4579-4585
Mo, Juan; Neelam, Sudha; Mellon, Jessamee et al. (2017) Effect of Corneal Nerve Ablation on Immune Tolerance Induced by Corneal Allografts, Oral Immunization, or Anterior Chamber Injection of Antigens. Invest Ophthalmol Vis Sci 58:137-148

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