Cellular Imaging and Morphometric Analysis Core Vision research at OUHSC has a very strong focus on understanding the function of ocular tissues at the cellular level in health and disease. Labeling, imaging, and quantitative analysis at the tissue, cellular, and subcellular levels are critical to every vision research lab on our campus. Furthermore, the rapid advancement of the field requires that our researchers incorporate new imaging modalities, analytical approaches, and hardware into their research programs. The methods, training, and facilities required for high quality cellular imaging are expensive, necessitating shared core facilities to foster innovative new research approaches and collaborations, to sustain high productivity, and remain at the forefront of the field. The Cellular Imaging and Morphometric Analysis Core provides highly knowledgeable expert support along with the bright field, epifluorescence, and scanning fluorescence microscopy at the macro (MVX10) and micro levelS (FV500 & FV1200). The highly sophisticated software packages (Metamorph and Imaris) enable vision researchers to generate new images and analyze them by software previously unavailable. The training of students, postdoctoral fellows, staff, and PIs in the use of the Cellular Imaging Core facilities greatly expands their investigative capabilities, develops creative ideas, and promotes collaborative interactions.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY021725-06
Application #
9152362
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
6
Fiscal Year
2016
Total Cost
$214,738
Indirect Cost
$69,645
Name
University of Oklahoma Health Sciences Center
Department
Type
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Bhatti, Faizah; Kung, Johannes W; Vieira, Frederico (2018) Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice. PLoS One 13:e0199824
Hopiavuori, Blake R; Deák, Ferenc; Wilkerson, Joseph L et al. (2018) Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency. Mol Neurobiol 55:1795-1813
Royer, Derek J; Elliott, Michael H; Le, Yun Z et al. (2018) Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II. Invest Ophthalmol Vis Sci 59:1512-1522
Yang, Fan; Ma, Hongwei; Butler, Michael R et al. (2018) Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice. FASEB J :fj201800484RR
Rajala, Raju V S; Rajala, Ammaji (2018) Redundant and Nonredundant Functions of Akt Isoforms in the Retina. Adv Exp Med Biol 1074:585-591
Yang, Fan; Ma, Hongwei; Boye, Sanford L et al. (2018) Overexpression of Type 3 Iodothyronine Deiodinase Reduces Cone Death in the Leber Congenital Amaurosis Model Mice. Adv Exp Med Biol 1074:125-131
Tarantini, Stefano; Valcarcel-Ares, M Noa; Yabluchanskiy, Andriy et al. (2018) Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. J Gerontol A Biol Sci Med Sci 73:853-863
Coburn, Phillip S; Miller, Frederick C; LaGrow, Austin L et al. (2018) TLR4 modulates inflammatory gene targets in the retina during Bacillus cereus endophthalmitis. BMC Ophthalmol 18:96
Sharif, Rabab; Priyadarsini, Shrestha; Rowsey, Tyler G et al. (2018) Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea. J Vis Exp :
Rajala, Ammaji; Wang, Yuhong; Rajala, Raju V S (2018) Constitutive Activation Mutant mTOR Promote Cone Survival in Retinitis Pigmentosa Mice. Adv Exp Med Biol 1074:491-497

Showing the most recent 10 out of 146 publications