ADMINISTRATIVE ARRANGEMENTS Principal Investigator: Linda M. Zangwill. PhD Dr. Linda Zangwill has the necessary leadership and management skills and experience to serve as PI of the UCSD NEI Vision Research Core. As Co-Director of Clinical Research, and as Director of the Imaging Data Evaluation and Analysis (IDEA) Reading Center, she has been responsible for development and expansion of the clinical research enterprise at the Hamilton Glaucoma Center. Dr. Zangwill has had continuous ROI funding since 1995 for the Diagnostic Innovations in Glaucoma Study (DIGS): Structural Assessment, which has led to significant improvements in our ability to 1) detect glaucomatous structural damage and change, 2) understand the complex relationship between optic disc damage and visual field loss, 3) measure the rate of structural change, 4) predict who will develop progressive visual field loss. In addition, as PI for the NEI funded African Descent and Glaucoma Evaluation Study (ADAGES), OHTS and EGPS: Glaucoma detection using Confocal Scanning Laser Ophthalmoscopy and co-Investigator for the CSLO Ancillary Study to the OHTS, Dr. Zangwill has proven leadership and management skills coordinating large national and international multi-center studies, working with collaborating investigators to set priorities, and meet deadlines while maintaining an extremely productive collaborative research program. Moreover, she has been responsible for the development of an integrated data management system that provides (on a secure shared server), reading center reviewed structural, functional, clinical and demographic data acquired from the DIGS and ADAGES to collaborating researchers for analysis. This data management system required the coordination between her computer group (3 FTEs), Reading Center staff (4 FTEs) and clinical research staff (4 staff) as well as collaborating clinical researchers (at UCSD and elsewhere) and statisticians. As PI for the UCSD Vision Research Core she will bring her management expertise to work with module directors and the Advisory committee to implement a transparent decision-making process, to establish realistic expectations with clear timelines and to ensure timely response to investigator and staff concerns.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY022589-02
Application #
8543737
Study Section
Special Emphasis Panel (ZEY1-VSN)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$30,205
Indirect Cost
$10,718
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Shim, Myoung Sup; Takihara, Yuji; Kim, Keun-Young et al. (2016) Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep 6:33830
Venugopalan, Praseeda; Wang, Yan; Nguyen, Tu et al. (2016) Transplanted neurons integrate into adult retinas and respond to light. Nat Commun 7:10472
Klingenstein, Annemarie; Schaumberger, Markus M; Freeman, William R et al. (2016) MuSIC report III: tumour microcirculation patterns and development of metastasis in long-term follow-up of melanocytic uveal tumours. Acta Ophthalmol 94:175-81
Zhang, Chunwei; Tatham, Andrew J; Abe, Ricardo Y et al. (2016) Corneal Hysteresis and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma. Am J Ophthalmol 166:29-36

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