RESEARCH PLAN: COMPUTATIONAL OPHTHALMOLOGY MODULE OVERVIEW At UCSD, structural imaging instruments such as the spectral domain optical coherence tomography (SD-OCT) and functional instruments are used extensively in animal (Drs. Weinreb, Freeman, Yu, La Spada, Zhang, Freeman) and human studies of glaucoma (Drs. Weinreb, Ju, Lindsay, Zangwill, Medeiros, Balasubramanian) and retinal disease (Drs. Freeman, Yu, Bartsch, Zhang, Cheng). The recent development and commercialization of imaging instruments such as SD-OCT has brought a significant improvement in our ability to visualize and measure the retina in-vivo in both animals and humans. These instruments have potential to dramatically improve our ability to understand the histopathology of major eyes diseases including glaucoma, age-related macular degeneration and diabetic retinopathy. These instruments represent a generational leap forward in technological development and several orders of magnitude more data than previous instruments. The challenge facing both ophthalmic clinicians and researchers is how best to utilize the vast quantity of data to 1) enhance our understanding of the histopathology of eye diseases, and 2) identify structural biomarkers of disease and its progression toward the ultimate goal of improving patient management. The computational ophthalmology module will provide essential centralized resources to support the computationally intensive analysis of structural imaging and functional tests used in animal and human vision research studies. This module will provide dedicated computational resources with a capacity to meet high computational demands and software toolkits that leverage these computational resources so that researchers can analyze the complex and data intensive retinal datasets (imaging and functional testing) outside of the proprietary software available with each ophthalmic test.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY022589-03
Application #
8689051
Study Section
Special Emphasis Panel (ZEY1-VSN)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
3
Fiscal Year
2014
Total Cost
$188,364
Indirect Cost
$66,839
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Medeiros, Felipe A; Gracitelli, Carolina P B; Boer, Erwin R et al. (2015) Longitudinal changes in quality of life and rates of progressive visual field loss in glaucoma patients. Ophthalmology 122:293-301
Arcinue, Cheryl A; Ma, Feiyan; Barteselli, Giulio et al. (2015) One-year outcomes of aflibercept in recurrent or persistent neovascular age-related macular degeneration. Am J Ophthalmol 159:426-36.e2
Barteselli, Giulio; Amini, Payam; Ezon, Isaac C et al. (2015) Impact on intraocular pressure after 20-mg decanted triamcinolone acetonide (kenalog) injection when using prophylactic antiglaucoma therapy. Retina 35:75-81
Duncan, Jacque L; Biswas, Pooja; Kozak, Igor et al. (2015) Ocular Phenotype of a Family with FAM161A-associated Retinal Degeneration. Ophthalmic Genet :9-Jan
Kador, Karl E; Alsehli, Haneen S; Zindell, Allison N et al. (2014) Retinal ganglion cell polarization using immobilized guidance cues on a tissue-engineered scaffold. Acta Biomater 10:4939-46
Wang, Feng; Wang, Hui; Tuan, Han-Fang et al. (2014) Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements. Hum Genet 133:331-45
Zhang, Chunwei; Tatham, Andrew J; Medeiros, Felipe A et al. (2014) Assessment of choroidal thickness in healthy and glaucomatous eyes using swept source optical coherence tomography. PLoS One 9:e109683
Chen, Szu-Yu; Mahabole, Megha; Horesh, Elan et al. (2014) Isolation and characterization of mesenchymal progenitor cells from human orbital adipose tissue. Invest Ophthalmol Vis Sci 55:4842-52
Tatham, Andrew J; Boer, Erwin R; Rosen, Peter N et al. (2014) Glaucomatous retinal nerve fiber layer thickness loss is associated with slower reaction times under a divided attention task. Am J Ophthalmol 158:1008-17
Luo, Jing; Baranov, Petr; Patel, Sherrina et al. (2014) Human retinal progenitor cell transplantation preserves vision. J Biol Chem 289:6362-71

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